YPR200C

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Systematic name YPR200C
Gene name ARR2
Aliases ACR2
Feature type ORF, Verified
Coordinates Chr XVI:939671..939279
Primary SGDID S000006404


Description of YPR200C: Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p[1][2]




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Community Commentary

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Other

Other

Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. [3] [4]


Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. [2] [4]


Protein Details

Protein Function/Process

Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. [1] [4]


Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. [5] [4]





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References

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  1. 1.0 1.1 Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 SGD PMID 9812373
  2. 2.0 2.1 Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57 SGD PMID 10801893 Cite error: Invalid <ref> tag; name "S000054698" defined multiple times with different content
  3. Mukhopadhyay R and Rosen BP (2001) The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. J Biol Chem 276(37):34738-42 SGD PMID 11461905
  4. 4.0 4.1 4.2 4.3 submitted by Barry Rosen on 2003-07-31
  5. Mukhopadhyay R, et al. (2003) Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. J Biol Chem 278(27):24476-80 SGD PMID 12711608

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