YDR172W
(Redirected from (PSI(+)))
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| Systematic name | YDR172W |
| Gene name | SUP35 |
| Aliases | GST1, PNM2, SAL3, SUF12, SUP2, SUP36, [PSI(+)], [PSI] |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:808324..810381 |
| Primary SGDID | S000002579 |
Description of YDR172W: Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype[1][2][3][4]
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References
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- ↑ Derkatch IL, et al. (2004) Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proc Natl Acad Sci U S A 101(35):12934-9 SGD PMID 15326312
- ↑ Funakoshi Y, et al. (2007) Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. Genes Dev 21(23):3135-48 SGD PMID 18056425
- ↑ Lindquist S, et al. (2001) Investigating protein conformation-based inheritance and disease in yeast. Philos Trans R Soc Lond B Biol Sci 356(1406):169-76 SGD PMID 11260797
- ↑ Salnikova AB, et al. (2005) Nonsense suppression in yeast cells overproducing Sup35 (eRF3) is caused by its non-heritable amyloids. J Biol Chem 280(10):8808-12 SGD PMID 15618222
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