YBR112C
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| Systematic name | YBR112C |
| Gene name | CYC8 |
| Aliases | CRT8, SSN6, [OCT1+], [OCT] |
| Feature type | ORF, Verified |
| Coordinates | Chr II:465770..462870 |
| Primary SGDID | S000000316 |
Description of YBR112C: General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+][1][2][3]
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Contents
Community Commentary
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Interactions
Other Interactions
Other Topic: functional dependence
Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Cyc8/Ssn6. [4] [5]
Physical
Physical interaction with Nrg1
Nrg1 interacts with Ssn6/Cyc8 in the two-hybrid system, and in GST pull-down experiments. [4] [5]
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References
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- ↑ Patel BK, et al. (2009) The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion. Nat Cell Biol 11(3):344-9 SGD PMID 19219034
- ↑ Proft M and Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17 SGD PMID 12086627
- ↑ Smith RL and Johnson AD (2000) Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. Trends Biochem Sci 25(7):325-30 SGD PMID 10871883
- ↑ 4.0 4.1 Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 SGD PMID 10022891
- ↑ 5.0 5.1 submitted by Valmik K. Vyas on 2003-02-12
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