Help:References

2008-04-29T18:23:12Z

Zhan8097:

Hui Yang, Qun Ren, and Zhaojie Zhang (2008)Cleavage of Mcd1 by Caspase-like Protease Esp1 Promotes Apoptosis in Budding Yeast. Mol. Biol Cell. 19 (5) 2127-2134

YDL003W

2008-04-29T18:20:36Z

Zhan8097: /* Community Commentary */

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{|{{Prettytable}} align = 'right' width = '200px'
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002161 YDL003W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MCD1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''PDS3, RHC21, SCC1''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr IV:444680..446380
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002161
|}
 
'''Description of YDL003W:''' Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase<ref name='S000054347'>Guacci V, et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91(1):47-57
{{SGDpaper|S000054347}} PMID 9335334</ref>
 
 
 
 
 
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==Community Commentary==
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Mcd1 also involves in hydrogen peroxide-induced apoptosis. Upon induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria, causing the decrease of mitochondrial membrane potential and the amplification of cell death in a cytochrome c-dependent manner.
MBC 19(5):2127-34,2008







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==References==

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Help:References

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