SGD-Wiki - User contributions [en]

YOL034W

2007-07-30T13:05:01Z

Torresrosell: /* Community Commentary */

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<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The Smc5-Smc6 complex binds to the ribosomal DNA array (rDNA) <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> <ref>Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.</ref>




<protect>

==References==

{{RefHelp}}
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YOL034W

2007-07-30T12:22:35Z

Torresrosell: /* Community Commentary */

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<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex is most probably related to chromosome segregation. The ribosomal DNA array (rDNA) appears to be the most affected locus, and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> <ref>Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.</ref>




<protect>

==References==

{{RefHelp}}
</protect>

YOL034W

2007-07-30T12:18:53Z

Torresrosell: /* Community Commentary */

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<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex appears to be related to the segregation of the ribosomal DNA array (rDNA) and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref> <ref>Cost GJ, Cozzarelli NR (2006) Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae. Genetics 172(4):2185-200.</ref>




<protect>

==References==

{{RefHelp}}
</protect>

YOL034W

2007-07-30T12:13:36Z

Torresrosell: /* Community Commentary */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>. The essential function of the Smc5-Smc6 complex appears to be related to the segregation of the ribosomal DNA array (rDNA) and smc5-smc6 thermosensitive mutants fail to segregate the rDNA when grown at the restrictive temperature <ref>Torres-Rosell J, et al. (2005) SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions. Nat Cell Biol. 2005 7(4):412-9 </ref>.




<protect>

==References==

{{RefHelp}}
</protect>

YOL034W

2007-07-30T12:08:43Z

Torresrosell: /* Community Commentary */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. The complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>.




<protect>

==References==

{{RefHelp}}
</protect>

YOL034W

2007-07-30T12:08:10Z

Torresrosell: /* Community Commentary */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

Smc5 is one of the two SMC proteins that forms the core of the Smc5-Smc6 complex. The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. BThe complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>.




<protect>

==References==

{{RefHelp}}
</protect>

YOL034W

2007-07-30T12:06:16Z

Torresrosell: /* Community Commentary */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005394 YOL034W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SMC5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:259924..263205
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005394
|}
 
'''Description of YOL034W:''' Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000075870'>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39 {{SGDpaper|S000075870}} PMID 15010319</ref><ref name='S000069988'>Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
{{SGDpaper|S000069988}} PMID 11927594</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}

The Smc5-Smc6 complex is, together with cohesin and condensin, one of the three essential eukaryotic SMC complexes. Besides the core Smc5 and Smc6 proteins, the complex has six non-Smc subunits, named Nse1, Nse2, Nse3, Nse4, Nse5 and Nse6. The Smc5-Smc6 complex has been shown to have a role in DNA repair, as well as an essential function. Smc5-Smc6 participates in an undefined step of homologous recombination <ref>Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst). 3(4):429-39</ref> and it is recruited to DNA double strand breaks to promote sister chromatid recombination <ref>de Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol. 8(9):1032-4 </ref>.




<protect>

==References==

{{RefHelp}}
</protect>