YCL061C

2011-02-25T01:23:18Z

Theresaberens: /* Community Commentary */

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000566 YCL061C]
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MRC1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''YCL060C''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr III:22106..18816
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000566
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'''Description of YCL061C:''' S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres<ref name='S000073860'>Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 {{SGDpaper|S000073860}} PMID 12944972</ref><ref name='S000128058'>Lou H, et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32(1):106-17 {{SGDpaper|S000128058}} PMID 18851837</ref><ref name='S000073790'>Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 {{SGDpaper|S000073790}} PMID 12865299</ref><ref name='S000123337'>Tsolou A and Lydall D (2007) Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1. DNA Repair (Amst) 6(11):1607-1617
{{SGDpaper|S000123337}} PMID 17618841</ref>
 
 
 
 
 
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==Community Commentary==
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=== DNA and RNA Details ===
[[Category:Topic:DNA and RNA Details]]
==== Other DNA and RNA Details ====
[[Category:Topic:DNA and RNA Details:Other DNA and RNA Details]]
'''Other Topic''': expression [[Category:Topic:expression]]

Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. <ref name='S000073646'>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 {{SGDpaper|S000073646}} PMID 12414795</ref> <ref name = 'CAset9153-2003-07-25'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9153 Viktor Boer] on 2003-07-25</ref>

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The MRC1 deletion in the systematic deletion collection uses a start codon 3' of the real start codon. Thus, it truncates and DAmPs the gene rather than deleting it.




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==References==

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YCL061C