YLL043W

2007-06-23T05:06:07Z

S Hohmann: /* Community Commentary */

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{|{{Prettytable}} align = 'right' width = '200px'
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003966 YLL043W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FPS1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XII:49937..51946
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003966
|}
 
'''Description of YLL043W:''' Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite<ref name='S000060866'>Wysocki R, et al. (2001) The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol 40(6):1391-401 {{SGDpaper|S000060866}} PMID 11442837</ref><ref name='S000046364'>Luyten K, et al. (1995) Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J 14(7):1360-71 {{SGDpaper|S000046364}} PMID 7729414</ref><ref name='S000044207'>Tamas MJ, et al. (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31(4):1087-104
{{SGDpaper|S000044207}} PMID 10096077</ref>
 
 
 
 
 
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==Community Commentary==
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=== Protein Details ===
[[Category:Topic:Protein Details]]
==== Protein Function/Process ====
[[Category:Topic:Protein Details:Protein Function/Process]]

Disruption of the FPS1 gene for the aquaglyceroporin Fps1p reduced uptake of 73As(III) into cells, conferring resistance to arsenite. The arsenate-resistant phenotype could be functionally complemented by expression of AQP9, a mammalian homologue <ref name='S000069730'>Liu Z, et al. (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A 99(9):6053-8 {{SGDpaper|S000069730}} PMID 11972053</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref>

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The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions. The mechanism of gating is not fully understood but requires certain conserved domains of Fps1 and, directly or indirectly, the Hog1 MAPK.




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==References==

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==References==

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YLL043W

2007-05-04T15:08:59Z

S Hohmann: /* Community Commentary */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003966 YLL043W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''FPS1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XII:49937..51946
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003966
|}
 
'''Description of YLL043W:''' Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite<ref name='S000060866'>Wysocki R, et al. (2001) The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol 40(6):1391-401 {{SGDpaper|S000060866}} PMID 11442837</ref><ref name='S000046364'>Luyten K, et al. (1995) Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J 14(7):1360-71 {{SGDpaper|S000046364}} PMID 7729414</ref><ref name='S000044207'>Tamas MJ, et al. (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31(4):1087-104
{{SGDpaper|S000044207}} PMID 10096077</ref>
 
 
 
 
 
</protect>
__TOC__
==Community Commentary==
{{CommentaryHelp}}
=== Protein Details ===
[[Category:Topic:Protein Details]]
==== Protein Function/Process ====
[[Category:Topic:Protein Details:Protein Function/Process]]

Disruption of the FPS1 gene for the aquaglyceroporin Fps1p reduced uptake of 73As(III) into cells, conferring resistance to arsenite. The arsenate-resistant phenotype could be functionally complemented by expression of AQP9, a mammalian homologue <ref name='S000069730'>Liu Z, et al. (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A 99(9):6053-8 {{SGDpaper|S000069730}} PMID 11972053</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref>

{{ShortCenteredHR}}

The main role of Fps1 is export of glycerol for osmoregulation. Fps1 transport function is gated to ensure glycerol accummulation and glycerol release depending on osmotic conditions.




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==References==

{{RefHelp}}
</protect>

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YLL043W

YLL043W