YML060W

2008-05-16T18:38:23Z

Oggone: /* Community Commentary */

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{|{{Prettytable}} align = 'right' width = '200px'
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004525 YML060W]
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''OGG1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XIII:151871..153001
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004525
|}
 
'''Description of YML060W:''' Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA<ref name='S000059916'>Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 {{SGDpaper|S000059916}} PMID 11239005</ref><ref name='S000047535'>Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 {{SGDpaper|S000047535}} PMID 9358166</ref><ref name='S000046294'>van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202 {{SGDpaper|S000046294}} PMID 8643552</ref><ref name='S000046177'>Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80
{{SGDpaper|S000046177}} PMID 8805338</ref>
 
 
 
 
 
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==Community Commentary==
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S. cerevisiae ''OGG1'' gene was first cloned by functional complementation of E.coli fpg mutY double mutant. However, there is no obvious sequence homology betweeen these two proteins. The Ogg1 protein is conserved in eukaryotes, from yeat to mammals.




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==References==

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YML060W

2008-05-08T13:42:56Z

Oggone: /* Community Commentary */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004525 YML060W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''OGG1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XIII:151871..153001
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004525
|}
 
'''Description of YML060W:''' Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA<ref name='S000059916'>Singh KK, et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res 29(6):1381-8 {{SGDpaper|S000059916}} PMID 11239005</ref><ref name='S000047535'>Sandigursky M, et al. (1997) The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity. Nucleic Acids Res 25(22):4557-61 {{SGDpaper|S000047535}} PMID 9358166</ref><ref name='S000046294'>van der Kemp PA, et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc Natl Acad Sci U S A 93(11):5197-202 {{SGDpaper|S000046294}} PMID 8643552</ref><ref name='S000046177'>Nash HM, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6(8):968-80
{{SGDpaper|S000046177}} PMID 8805338</ref>
 
 
 
 
 
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==Community Commentary==
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==References==

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SGD-Wiki - User contributions [en]

YML060W

YML060W