SGD-Wiki - User contributions [en]

What are yeast?

2013-04-11T17:28:09Z

Marek: /* Resources */

[[File:Fungi.jpeg|thumb|left|'''Introduction to Fungi''' Credit: ''Kandis Elliot, Mo Fayyaz, University of Wisconsin, Madison'']]

====General Information====
[http://en.wikipedia.org/wiki/Yeast Yeast] are single-celled eukaryotic microorganisms that are classified, along with molds and mushrooms, as members of the kingdom [http://en.wikipedia.org/wiki/Fungus Fungi]. Yeasts are phylogenetically diverse, and as such are classified in two separate phyla, the [http://en.wikipedia.org/wiki/Ascomycota ''Ascomycota''] and the [http://en.wikipedia.org/wiki/Basidiomycota ''Basidiomycota'']. Budding yeast (also called “true yeasts”), such as the well-known species [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''], are classified in the order [http://en.wikipedia.org/wiki/Saccharomycetales ''Saccharomycetales''] under the phylum ''Ascomycota''. Such classifications are based on characteristics of the cell, ascospore, and colony, as well as on physiology. One of the most well known characteristics of yeast is its ability to ferment sugars for the production of ethanol and carbon dioxide.
[[File:Candida albicans.jpeg|thumb|right|130px|''C. albicans'', Credit: ''E. Gueho/Science Photo Library'']]

Yeast are characterized by a wide dispersion of natural habitats. They are common on plant leaves, flowers, and fruits, as well as in soil. Yeast are also found on the skin surfaces and in the intestinal tracts of
warm-blooded animals, where they may live symbiotically or as parasites. The common "yeast infection" [http://en.wikipedia.org/wiki/Candidiasis ''Candidiasis'']
is typically caused by [http://en.wikipedia.org/wiki/Candida_albicans ''Candida albicans'']. In addition to being the causative agent in vaginal yeast infections ''Candida'' is also a cause of diaper rash and
thrush of the mouth and throat.

[[File:EM yeast.jpeg|thumb|left|150px|'''EM image of ''S. cerevisiae''''' Credit: ''UC Berkeley'']]

[[File:Pombe cerevisiae.jpg|thumb|right|175px|'''Fission (''S. pombe'') and budding (''S. cerevisiae'') yeasts''' Credit: ''Susan L. Forsberg, Nat Rev Gen '''2''':659'']]
Yeast reproduce asexually by an asymmetric division process called budding (eg. [http://en.wikipedia.org/wiki/Saccharomyces ''Saccharomyces'']), by a symmetric division process called fission (eg. [http://en.wikipedia.org/wiki/Schizosaccharomyces ''Schizosaccharomyces'']), or they can grow as simple irregular filaments (mycelium). In budding, a small bud emerges from the surface of the parent cell and enlarges until it is almost the size of the parent, while in fission the rod shaped cell grows at the cell's tips and then divides in half to produce two daughter cells of equal size. Yeast can also reproduce sexually, and most do so my forming asci,
which contain up to eight haploid ascospores. These ascospores may
fuse with adjoining nuclei and multiply through vegetative division
or, as with certain yeast, fuse with other ascospores.

====Commercial Applications====
''Saccharomyces cerevisiae'', one of the most well-known and commercially significant species of yeast, , has long been used as a leavening agent in baking. ''S. cerevisiae'', commonly known as baker’s yeast, ferment sugars present in dough to carbon dioxide and ethanol. The carbon dioxide becomes trapped in small bubbles in the dough, which causes the dough to rise. [[File:Sourdough-bread.jpeg|thumb|right|x100px|'''Wild yeast and acid-generating bacteria are used in making sourdough bread''']] Sourdough bread is not produced with baker's yeast, rather a combination of wild yeast (often [http://en.wikipedia.org/wiki/Candida_milleri ''Candida milleri'']) and an acid-generating bacteria ([http://en.wikipedia.org/wiki/Lactobacillus_sanfranciscensis ''Lactobacillus sanfranciscensis''] sp. nov). The ''C. milleri'' strengthens the gluten and the ''L. sanfrancisco'' ferments the maltose.

[[File:Hansen-emil-christian.jpeg|thumb|left|x150px|'''Dr. Emil Christian Hansen''', ''1842-1909'']]
''Saccharomyces cerevisiae'' and other yeast species have also long been used to ferment the sugars of rice, wheat, barley, and corn to produce alcoholic beverages such as beer and wine. There are two major classes of beer brewing yeast: ale yeast (top-fermenting type) and lager yeast (bottom-fermenting type). Ales are produced by ''S. cerevisiae'', the same yeast used to make bread. These yeast rise to the surface during fermentation, and hence are called top-fermenting yeast. Top-fermenting yeasts are used to brew ales, porters, stouts, and wheat beers. Lagers, on the other hand, are produced by [http://en.wikipedia.org/wiki/Saccharomyces_pastorianus ''Saccharomyces pastorianus'']. This yeast species was formerly known as ''Saccharomyces carlsbergensis'', named after the Carlsberg Brewery in Copenhagen where it was first isolated in pure culture by Dr. Emil Christian Hansen in 1883. Lager yeast are best used at lower temperatures and grow slower than ale yeast. As a result, they produce less surface foam and typically settle to the bottom of the fermenter, and are thus called bottom-type fermenters. Some of the lager styles made from bottom-fermenting yeasts include Pilsners, Märzen, Bocks, and American malt liquors. In modern beer brewing many of the original top fermentation strains have been modified to be bottom fermenters.

[[File:Bunches of grapes on vines at Trinity Hill vineyard in the Gimblett Gravels region Hawkes Bay NZ 13-15Feb08.jpg|thumb|150px|right|'''Bunches of grapes on vines at Trinity Hill vineyard in Hawkes Bay NZ''']]

Yeast produce wine by fermenting sugars present in grape juice (must) into ethanol. The fermentation of wine can be initiated by naturally occurring yeast present in the vineyards, but many wineries choose to add a pure yeast culture to dominate and control the fermentation. The bubbles in champagne and sparkling wines are produced by a secondary fermentation, typically in the bottle, which traps the carbon dioxide. Carbon dioxide produced in wine production is released as a by-product. One yeast cell can ferment approximately its own weight of glucose per hour. Under optimal conditions ''S. cerevisiae'' can produce up to 18 percent, by volume, ethanol with 15 to 16 percent being the norm. The sulfur dioxide present in commercially produced wine is actually added just after the grapes are crushed to kill the naturally present bacteria, mold, and yeast.

The in-depth knowledge of ''S. cerevisiae'' and it's ability to be metabolically engineered has made it an important organism in the production of specialty chemicals, such as biofuels, industrial lubricants, detergents, and biopharmaceuticals.

====Yeast as a Model Organism====
Yeast, particularly ''S. cerevisiae'', became a model organism for studying cell biology and genetics because it is a single-celled eukaryote that is fairly easy to grow and manipulate genetically. In addition, the basic cellular mechanics of replication, recombination, cell division and metabolism are generally conserved between it and more complex eukaryotes, including humans. As a result yeast are one of the most thoroughly researched eukaryotic organisms. In 1996, ''S. cerevisiae'' was the first eukaryote to have its genome completely sequenced. Several significant scientific discoveries have been made through ''S. cerevisiae'' research, including some which have led to Nobel Prizes. These include an award to Drs. Leland Hartwell, Tim Hunt, and Paul Nurse in 2001 for their discovery of genes involved in regulating the cell cycle, as well as a 2009 award to Drs. Elizabeth Blackburn, Carol Greider, and Jack Szostak for their work showing how telomeres and the enzyme telomerase protect the ends of chromosomes from degradation.

==Resources==

* [http://www.yeastgenome.org/ ''Saccharomyces'' Genome Database (SGD)] provides comprehensive integrated biological information for the budding yeast ''Saccharomyces cerevisiae'' along with search and analysis tools to explore these data.

* [http://www.candidagenome.org/ ''Candida'' Genome Database (CGD)], a resource for genomic sequence data and gene and protein information for Candida albicans and related species.

* [http://www.pombase.org/ PomBase], a comprehensive database for the fission yeast ''Schizosaccharomyces pombe'', providing structural and functional annotation, literature curation and access to large-scale data sets.

* [http://www.ncbi.nlm.nih.gov/projects/genome/guide/fungi/ Fungal Genomes Central], a portal to information and resources about fungi and fungal sequencing projects from NCBI and the fungi research community.

* An extensive list of [http://wiki.yeastgenome.org/index.php/External_Links yeast-related resources] on topics ranging from general yeast information to nucleic acids, genomes and proteins, expression data, localization, phenotypes and more.

==Suggested Reading==

* [http://www.genetics.org/content/189/3/695.full.pdf+html Yeast: An Experimental Organism for 21st Century Biology]. (2011) David Botstein & Gerald R Fink, Genetics. 2011 Nov;189(3):695-704.

* [http://www.genetics.org/site/misc/yeastbook.xhtml YeastBook]. (2011) ''A comprehensive compendium of reviews that presents the current state of knowledge of the molecular biology, cellular biology, and genetics of the yeast Saccharomyces cerevisiae'', Genetics

* [http://books.google.com/books/about/From_a_to_alpha.html?id=79hO0A08odkC From a to alpha: Yeast as a Model for Cellular Differentiation]. (2007) Hitan D. Madhani, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?action=full&cart=133468404249500843&--eqskudatarq=449&newtitle=Landmark%20Papers%20in%20Yeast%20Biology Landmark Papers in Yeast Biology]. (2006), edited by Patrick Linder, David Shore, and Michael N. Hall, Cold Spring Harbor Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?action=full&cart=133468404249500843&--eqskudatarq=526&newtitle=Methods%20in%20Yeast%20Genetics%3A%20A%20Cold%20Spring%20%20Harbor%20Laboratory%20Course%20Manual%2C%202005%20Edition Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual]. (2005) David C. Amberg, Daniel J. Burke, and Jeffrey N. Strathern. Cold Spring Laboratory Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?cart=133468183249354789&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=676 The Early Days of Yeast Genetics]. (1993) edited by Michael N. Hall and Patrick Linder. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?action=full&cart=133468299549480865&--eqskudatarq=189&newtitle=The%20Yeast%20Saccharomyces%3A%20Gene%20Expression The Molecular and Cellular Biology of the Yeast ''Saccharomyces cerevisiae'': Gene Expression]. (1992) edited by Elizabeth W. Jones, John R. Pringle, and James R. Broach. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* Mortimer, R.K., Contopoulou, C.R. and J.S. King (1992) [http://www.ncbi.nlm.nih.gov/pubmed/1413997 Genetic and physical maps of ''Saccharomyces cerevisiae''], Edition 11. Yeast '''8''':817-902.

* [http://www.cshlpress.com/default.tpl?action=full&--eqskudatarq=190 The Molecular and Cellular Biology of the Yeast ''Saccharomyces cerevisiae'': Genome Dynamics, Protein Synthesis, and Energetics]. (1991) edited by James R. Broach, John R. Pringle, and Elizabeth W. Jones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* [http://books.google.com/books/about/Yeast.html?id=-GkHRQAACAAJ Yeast: A Practical Approach]. (1988) edited by I. Campbell and , and John H. Duffus, IRL Press, Ithaca, New York.

* The Life of Yeasts. (1978) H.J. Phaff, M.W. Miller, and E. M. Mrak, Harvard University Press, Cambridge, Massachussetts.

What are yeast?

2013-04-11T17:27:41Z

Marek: /* Resources */

[[File:Fungi.jpeg|thumb|left|'''Introduction to Fungi''' Credit: ''Kandis Elliot, Mo Fayyaz, University of Wisconsin, Madison'']]

====General Information====
[http://en.wikipedia.org/wiki/Yeast Yeast] are single-celled eukaryotic microorganisms that are classified, along with molds and mushrooms, as members of the kingdom [http://en.wikipedia.org/wiki/Fungus Fungi]. Yeasts are phylogenetically diverse, and as such are classified in two separate phyla, the [http://en.wikipedia.org/wiki/Ascomycota ''Ascomycota''] and the [http://en.wikipedia.org/wiki/Basidiomycota ''Basidiomycota'']. Budding yeast (also called “true yeasts”), such as the well-known species [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae ''Saccharomyces cerevisiae''], are classified in the order [http://en.wikipedia.org/wiki/Saccharomycetales ''Saccharomycetales''] under the phylum ''Ascomycota''. Such classifications are based on characteristics of the cell, ascospore, and colony, as well as on physiology. One of the most well known characteristics of yeast is its ability to ferment sugars for the production of ethanol and carbon dioxide.
[[File:Candida albicans.jpeg|thumb|right|130px|''C. albicans'', Credit: ''E. Gueho/Science Photo Library'']]

Yeast are characterized by a wide dispersion of natural habitats. They are common on plant leaves, flowers, and fruits, as well as in soil. Yeast are also found on the skin surfaces and in the intestinal tracts of
warm-blooded animals, where they may live symbiotically or as parasites. The common "yeast infection" [http://en.wikipedia.org/wiki/Candidiasis ''Candidiasis'']
is typically caused by [http://en.wikipedia.org/wiki/Candida_albicans ''Candida albicans'']. In addition to being the causative agent in vaginal yeast infections ''Candida'' is also a cause of diaper rash and
thrush of the mouth and throat.

[[File:EM yeast.jpeg|thumb|left|150px|'''EM image of ''S. cerevisiae''''' Credit: ''UC Berkeley'']]

[[File:Pombe cerevisiae.jpg|thumb|right|175px|'''Fission (''S. pombe'') and budding (''S. cerevisiae'') yeasts''' Credit: ''Susan L. Forsberg, Nat Rev Gen '''2''':659'']]
Yeast reproduce asexually by an asymmetric division process called budding (eg. [http://en.wikipedia.org/wiki/Saccharomyces ''Saccharomyces'']), by a symmetric division process called fission (eg. [http://en.wikipedia.org/wiki/Schizosaccharomyces ''Schizosaccharomyces'']), or they can grow as simple irregular filaments (mycelium). In budding, a small bud emerges from the surface of the parent cell and enlarges until it is almost the size of the parent, while in fission the rod shaped cell grows at the cell's tips and then divides in half to produce two daughter cells of equal size. Yeast can also reproduce sexually, and most do so my forming asci,
which contain up to eight haploid ascospores. These ascospores may
fuse with adjoining nuclei and multiply through vegetative division
or, as with certain yeast, fuse with other ascospores.

====Commercial Applications====
''Saccharomyces cerevisiae'', one of the most well-known and commercially significant species of yeast, , has long been used as a leavening agent in baking. ''S. cerevisiae'', commonly known as baker’s yeast, ferment sugars present in dough to carbon dioxide and ethanol. The carbon dioxide becomes trapped in small bubbles in the dough, which causes the dough to rise. [[File:Sourdough-bread.jpeg|thumb|right|x100px|'''Wild yeast and acid-generating bacteria are used in making sourdough bread''']] Sourdough bread is not produced with baker's yeast, rather a combination of wild yeast (often [http://en.wikipedia.org/wiki/Candida_milleri ''Candida milleri'']) and an acid-generating bacteria ([http://en.wikipedia.org/wiki/Lactobacillus_sanfranciscensis ''Lactobacillus sanfranciscensis''] sp. nov). The ''C. milleri'' strengthens the gluten and the ''L. sanfrancisco'' ferments the maltose.

[[File:Hansen-emil-christian.jpeg|thumb|left|x150px|'''Dr. Emil Christian Hansen''', ''1842-1909'']]
''Saccharomyces cerevisiae'' and other yeast species have also long been used to ferment the sugars of rice, wheat, barley, and corn to produce alcoholic beverages such as beer and wine. There are two major classes of beer brewing yeast: ale yeast (top-fermenting type) and lager yeast (bottom-fermenting type). Ales are produced by ''S. cerevisiae'', the same yeast used to make bread. These yeast rise to the surface during fermentation, and hence are called top-fermenting yeast. Top-fermenting yeasts are used to brew ales, porters, stouts, and wheat beers. Lagers, on the other hand, are produced by [http://en.wikipedia.org/wiki/Saccharomyces_pastorianus ''Saccharomyces pastorianus'']. This yeast species was formerly known as ''Saccharomyces carlsbergensis'', named after the Carlsberg Brewery in Copenhagen where it was first isolated in pure culture by Dr. Emil Christian Hansen in 1883. Lager yeast are best used at lower temperatures and grow slower than ale yeast. As a result, they produce less surface foam and typically settle to the bottom of the fermenter, and are thus called bottom-type fermenters. Some of the lager styles made from bottom-fermenting yeasts include Pilsners, Märzen, Bocks, and American malt liquors. In modern beer brewing many of the original top fermentation strains have been modified to be bottom fermenters.

[[File:Bunches of grapes on vines at Trinity Hill vineyard in the Gimblett Gravels region Hawkes Bay NZ 13-15Feb08.jpg|thumb|150px|right|'''Bunches of grapes on vines at Trinity Hill vineyard in Hawkes Bay NZ''']]

Yeast produce wine by fermenting sugars present in grape juice (must) into ethanol. The fermentation of wine can be initiated by naturally occurring yeast present in the vineyards, but many wineries choose to add a pure yeast culture to dominate and control the fermentation. The bubbles in champagne and sparkling wines are produced by a secondary fermentation, typically in the bottle, which traps the carbon dioxide. Carbon dioxide produced in wine production is released as a by-product. One yeast cell can ferment approximately its own weight of glucose per hour. Under optimal conditions ''S. cerevisiae'' can produce up to 18 percent, by volume, ethanol with 15 to 16 percent being the norm. The sulfur dioxide present in commercially produced wine is actually added just after the grapes are crushed to kill the naturally present bacteria, mold, and yeast.

The in-depth knowledge of ''S. cerevisiae'' and it's ability to be metabolically engineered has made it an important organism in the production of specialty chemicals, such as biofuels, industrial lubricants, detergents, and biopharmaceuticals.

====Yeast as a Model Organism====
Yeast, particularly ''S. cerevisiae'', became a model organism for studying cell biology and genetics because it is a single-celled eukaryote that is fairly easy to grow and manipulate genetically. In addition, the basic cellular mechanics of replication, recombination, cell division and metabolism are generally conserved between it and more complex eukaryotes, including humans. As a result yeast are one of the most thoroughly researched eukaryotic organisms. In 1996, ''S. cerevisiae'' was the first eukaryote to have its genome completely sequenced. Several significant scientific discoveries have been made through ''S. cerevisiae'' research, including some which have led to Nobel Prizes. These include an award to Drs. Leland Hartwell, Tim Hunt, and Paul Nurse in 2001 for their discovery of genes involved in regulating the cell cycle, as well as a 2009 award to Drs. Elizabeth Blackburn, Carol Greider, and Jack Szostak for their work showing how telomeres and the enzyme telomerase protect the ends of chromosomes from degradation.

==Resources==

* [http://www.yeastgenome.org/ ''Saccharomyces'' Genome Database (SGD)] provides comprehensive integrated biological information for the budding yeast ''Saccharomyces cerevisiae'' along with search and analysis tools to explore these data.

* [http://www.candidagenome.org/ ''Candida'' Genome Database (CGD)], a resource for genomic sequence data and gene and protein information for Candida albicans and related species.

* [http://www.pombase.org/ PomBase], a comprehensive database for the fission yeast ''Schizosaccharomyces pombe'', providing structural and functional annotation, literature curation and access to large-scale data sets.

* [http://www.ncbi.nlm.nih.gov/projects/genome/guide/fungi/ Fungal Genomes Central], a portal to information and resources about fungi and fungal sequencing projects from NCBI and the fungi research community.

* An extensive list of [http://wiki.yeastgenome.org/index.php/External_Links yeast-related resources] on topics ranging from general yeast information to nucleic acids, genomes and proteins, expression data, localization, phenotypes and more.

==Suggested Reading==

* [http://www.genetics.org/content/189/3/695.full.pdf+html Yeast: An Experimental Organism for 21st Century Biology]. (2011) David Botstein & Gerald R Fink, Genetics. 2011 Nov;189(3):695-704.

* [http://www.genetics.org/site/misc/yeastbook.xhtml YeastBook]. (2011) ''A comprehensive compendium of reviews that presents the current state of knowledge of the molecular biology, cellular biology, and genetics of the yeast Saccharomyces cerevisiae'', Genetics

* [http://books.google.com/books/about/From_a_to_alpha.html?id=79hO0A08odkC From a to alpha: Yeast as a Model for Cellular Differentiation]. (2007) Hitan D. Madhani, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?action=full&cart=133468404249500843&--eqskudatarq=449&newtitle=Landmark%20Papers%20in%20Yeast%20Biology Landmark Papers in Yeast Biology]. (2006), edited by Patrick Linder, David Shore, and Michael N. Hall, Cold Spring Harbor Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?action=full&cart=133468404249500843&--eqskudatarq=526&newtitle=Methods%20in%20Yeast%20Genetics%3A%20A%20Cold%20Spring%20%20Harbor%20Laboratory%20Course%20Manual%2C%202005%20Edition Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual]. (2005) David C. Amberg, Daniel J. Burke, and Jeffrey N. Strathern. Cold Spring Laboratory Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?cart=133468183249354789&fromlink=T&linkaction=full&linksortby=oop_title&--eqSKUdatarq=676 The Early Days of Yeast Genetics]. (1993) edited by Michael N. Hall and Patrick Linder. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* [http://www.cshlpress.com/default.tpl?action=full&cart=133468299549480865&--eqskudatarq=189&newtitle=The%20Yeast%20Saccharomyces%3A%20Gene%20Expression The Molecular and Cellular Biology of the Yeast ''Saccharomyces cerevisiae'': Gene Expression]. (1992) edited by Elizabeth W. Jones, John R. Pringle, and James R. Broach. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* Mortimer, R.K., Contopoulou, C.R. and J.S. King (1992) [http://www.ncbi.nlm.nih.gov/pubmed/1413997 Genetic and physical maps of ''Saccharomyces cerevisiae''], Edition 11. Yeast '''8''':817-902.

* [http://www.cshlpress.com/default.tpl?action=full&--eqskudatarq=190 The Molecular and Cellular Biology of the Yeast ''Saccharomyces cerevisiae'': Genome Dynamics, Protein Synthesis, and Energetics]. (1991) edited by James R. Broach, John R. Pringle, and Elizabeth W. Jones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

* [http://books.google.com/books/about/Yeast.html?id=-GkHRQAACAAJ Yeast: A Practical Approach]. (1988) edited by I. Campbell and , and John H. Duffus, IRL Press, Ithaca, New York.

* The Life of Yeasts. (1978) H.J. Phaff, M.W. Miller, and E. M. Mrak, Harvard University Press, Cambridge, Massachussetts.

General Topics

2013-04-11T17:22:14Z

Marek: /* Fungal genome database projects */

This page has replaced the Virtual Library.
=General S. cerevisiae information=

*Generally speaking:
**[[What_are_yeast?|What are yeast?]]
**Here are some [http://www.yeastgenome.org/yeast_images.shtml pictures] of yeast

*The [http://www.yeastgenome.org/community/ArtOfBrewing.htm Art of Brewing], courtesy of [http://www.millerbrewing.com/ Miller Brewing Company].

*Information about winemaking, from [http://www.wine-oenology.com Wine High School of The Champagne region].

*Information about yeast and bread baking, from [http://www.breadworld.com/ Fleischmann's] and [http://www.redstaryeast.com/ Red Star Yeast] companies.

*Information about the yeast-based foods [http://www.accomodata.co.uk/marmite.htm Marmite] and [http://www.vegemite.com.au/ Vegemite].

*An [http://dbb.urmc.rochester.edu/labs/Sherman_f/yeast/Index.html introduction] to yeast, the most ideal eukaryotic microorganism for biological studies, written by Fred Sherman.

*An updated version of the yeast primer [http://dbb.urmc.rochester.edu/labs/sherman_f/StartedYeast.html Getting Started with Yeast] written by Fred Sherman.

*[http://biochemie.web.med.uni-muenchen.de/Yeast_Biol/ Yeast Molecular Biology: A Short Compendium on Basic Features and Novel Aspects] written by Horst Feldmann at the University of Munich

*Download a [http://www.yeastgenome.org/sgdpub/Saccharomyces_cerevisiae.pdf guide to S.cerevisiae nomenclature], published in [http://www.sciencedirect.com/science/journal/01689525 Trends in Genetics].

*A [[Polymerase_targets|table]] describing the gene targets of the different RNA polymerases in S. cerevisiae.

*A [http://www.usask.ca/biology/sgd/sgd1.html tutorial] from the University of Saskatchewan provides an introduction to SGD and to S. cerevisiae molecular biology and genetics.

*A [[External_Links|list]] of websites with relevance to S. cerevisiae molecular biology and genetics and to general molecular biology.

*Search the [http://www.bio.net/hypermail/yeast/ Yeast BioSci] (a.k.a. BioNet) Electronic Conference

*Usenet group on yeast molecular biology: [http://www.bio.net/hypermail/yeast/ bionet.molbio.yeast]

*Curated publications at SGD describing [http://www.yeastgenome.org/cgi-bin/reference/reference.pl?topic=Industrial%20Applications industrial uses of yeast], such as biofuels, winemaking, brewing.

*Curated publications at SGD addressing [http://www.yeastgenome.org/cgi-bin/reference/reference.pl?topic=Infection%20and%20Antifungals infections and antifungals] and [http://www.yeastgenome.org/cgi-bin/reference/reference.pl?topic=Disease%20Gene%20Related genes associated with diseases]

=Educational resources=

*[http://www.phys.ksu.edu/gene/ Genetics Education Network] Tom Manney's (Kansas State University) yeast experiments for undergrads and high school students. A well-done and informative web site for yeast in the classroom.

*[http://faculty.bsc.edu/phanson/yen/ Yeast Education Network] An archive of yeast-based teaching tools for the undergraduate classroom and laboratory. This site also includes most of the Education Workshop talks from YGM 2008.

*[http://www.cur.org/reslink2000.html Research Link 2000] Aimed at undergraduate classrooms, this is an offshoot of Tom Manney's yeast experiments. It also lists other model organisms.

*[http://www.woodrow.org/teachers/bi/1993/using.html Using Yeast As An Ultraviolet Light Measurement Tool.] This is a Tom Manney protocol rewritten by Kevin Conant, a participant in the Woodrow Wilson Biology Institute 1993.

*[http://www.mendelweb.org/ MendelWeb], an educational resource on the origins of classical genetics.

*[http://www.nsta.org National Science Teachers Association.] Resources for all science teachers from kindergarten to college.

*[http://www.nabt.org National Association of Biology Teachers] High school teachers predominate in this organization, but there are resources for post-secondary education as well.

*[http://www.asm.org American Society for Microbiology.] The ASM website lists resources in its education section. The ASM publishes numerous books on microbiology education at various levels.

*[http://www.bio.davidson.edu/courses/genomics/genomics.html Discovering Genomics, Proteomics, and Bioinformatics] This website describes a course and the accompanying textbook written by A. Malcolm Campbell and Laurie J. Heyer.

*[http://www.bio.davidson.edu/projects/GCAT/gcat.html Genome Consortium for Active Teaching (GCAT)] Description of the consortium and how it is working to bring functional genomics methods into the undergraduate biology curriculum.

*[http://www.actionbioscience.org/genomic/index.html Issues in Genomics] ActionBioscience.org lists a number of articles on genomics topics.

*[http://www.bio.davidson.edu/projects/magic/magic.html MicroArray Genome Imaging and Clustering Tool (MAGIC)] Open source software for analysis of large-scale gene expression datasets; developed by Laurie Heyer and her undergraduate students at Davidson College, North Carolina.

*[http://Vadlo.com VADLO Life Sciences Search Engine] from Life in Research, LLC. Provides search for life sciences research methods, databases, online tools, software, and powerpoints. For example [http://search.vadlo.com/b/q?k=Yeast+Protocols&rel=0 Yeast protocols], [http://search.vadlo.com/b/q?k=Yeast&rel=3 Yeast databases], [http://search.vadlo.com/b/q?k=Cerevisiae&rel=2 S. cerevisiae Powerpoints].

*[http://www.nature.com/scitable Scitable] A free library providing overviews of key science concepts, with a focus on genetics, compiled by the Nature Publishing Group.

*[http://www.guidetohealthcareschools.com/library/human-genetics The Human Genetics Education Resource] A general guide to resources in human genomics, inheritance, molecular genetics, genetic interactions, gene expression and evolution.

*[http://genetics.thetech.org/book-titles When Will Broccoli Taste Like Chocolate?: Your Questions on Genetic Traits Answered by Stanford University Scientists] A collection of general genetics questions and answers from the Ask a Geneticist section of [http://www.thetech.org/ The Tech Museum website].

=Schizosaccharomyces pombe information=

*[http://www.nature.com/nature/journal/v415/n6874/abs/nature724.html S. pombe genomic sequence] published by V. Wood et al., [http://www.nature.com Nature] 415, 871-880 (2002)

*[http://www.genedb.org/genedb/pombe/index.jsp PomBase] S. pombe database compiled at the [http://www.sanger.ac.uk/ Sanger Centre, UK]

*[http://www.sanger.ac.uk/cgi-bin/blast/submitblast/s_pombe Blast Server] for S. pombe compiled at the [http://www.sanger.ac.uk/ Sanger Centre, UK]

*[http://www.sanger.ac.uk/Projects/S_pombe/EUseqgrp.shtml European Schizosaccharomyces genome sequencing project]

*[http://www-rcf.usc.edu/~forsburg/ General information about S. pombe] from the Forsburg Lab

*[http://www-rcf.usc.edu/~forsburg/vectors.html S. pombe molecular genetics: plasmids, markers, maps and references] from the Forsburg Lab

*[http://www-rcf.usc.edu/~forsburg/genetable.html An S. pombe nomenclature guide]: S. pombe genes mapped to S. cerevisiae genes from the Forsburg Lab

=Candida albicans information=

*[http://candida.bri.nrc.ca/candida/index.cfm Candida albicans pages] at the NRC/BRI

*[http://www.candidagenome.org/ Candida Genome Database] at Stanford

*[http://www-sequence.stanford.edu/group/candida/ Candida information] from the Stanford Genome Technology Center

*[http://genolist.pasteur.fr/CandidaDB/ CandidaDB], a genomic database for C. albicans, part of the Galar Fungail Consortium project

*[http://albicansmap.ahc.umn.edu/ Institute for Candida experimentation] at the University of Minnesota

*[http://www.nlm.nih.gov/medlineplus/candidiasis.html Candidiasis information] at MEDLINE plus

*[http://agabian.ucsf.edu/ Annotation of the C. albicans genome] from the Agabian Lab

=Links to other fungal information=

*[http://botit.botany.wisc.edu/toms_fungi/ Tom Volk's Fungi]

*[http://www.doctorfungus.org/ Doctor Fungus]

*[http://www.fgsc.net/ The Fungal Genetics Stock Center]

=Fungal genome sequencing projects=

==Euascomycota==
*[http://www.tigr.org/tdb/e2k1/afu1/ Aspergillus fumigatus]
*[http://www.broad.mit.edu/annotation/fungi/aspergillus/ Aspergillus nidulans]
*[http://www.broad.mit.edu/annotation/fungi/magnaporthe/ Magnaporthe grisea]
*[http://www.broad.mit.edu/annotation/fungi/neurospora/ Neurospora crassa]

==Basidiomycota==

* ''Cryptococcus''
**[http://sequence-www.stanford.edu/group/C.neoformans/index.html ''Cryptococcus neoformans'' var. ''neoformans'' strain B3501]
** [http://www.tigr.org/tdb/e2k1/cna1/ ''Cryptococcus neoformans'' var. ''neoformans'' strain JEC21]
** ''Cryptococcus neoformans'' var. ''grubii'' H99 - [http://cneo.genetics.duke.edu/ Duke University], [http://www.broad.mit.edu/annotation/genome/cryptococcus_neoformans Fungal Genome Initiative]
** ''Cryptococcus gattii'' R265 - [http://www.broad.mit.edu/annotation/genome/cryptococcus_neoformans_b Fungal Genome Initiative]
** ''Cryptococcus gattii'' WM276 - [http://www.bcgsc.ca/project/cryptococcus/ Kronstad Lab/British Columbia Genome Sequencing Centre]

* [http://www.broad.mit.edu/annotation/genome/coprinus_cinereus/ ''Coprinus cinereus'']
* [http://www.broad.mit.edu/annotation/genome/puccinia_graminis ''Puccinia graminis f. sp. tritici'']
* [http://www.broad.mit.edu/annotation/genome/ustilago_maydis/ ''Ustilago maydis''], [http://mips.gsf.de/genre/proj/ustilago/ MIPS resources].

==Archiascomycota==
* [http://pgp.cchmc.org/ ''Pneumocystis carinii'']
* [http://www.broad.mit.edu/annotation/genome/schizosaccharomyces_japonicus ''Schizosaccharomyces japonicus'']

==Hemiascomycota==
* The [http://cbi.labri.fr/Genolevures/ Génolevures] project, featuring partial genomic sequence for 13 Hemiascomycete species

==Links==
* There is also [http://fungalgenomes.org/wiki/Fungal_Genome_Links list] of currently sequenced or in progress fungal genome projects with references.

=Fungal genome database projects=

*[http://www.aspgd.org/ Aspergillus Genome Database], a database for A. nidulans, A. fumigatus, A. niger and related species.
* [http://cryptogenome.ucsf.edu/ CryptoBase], a scientific database resource at [http://www.ucsf.edu UCSF] for ''C. neoformans'' var. ''grubii'' (serotype A)
*[http://fungal.genome.duke.edu fungal.genome.duke.edu], a scientific database resource at [http://www.duke.edu Duke University] providing Genome Browser, BLAST, and downloadable genome annotations for many fungal genomes.

Meetings

2012-05-29T14:06:16Z

Marek: /* Upcoming Conferences & Courses */

Meetings that may be of interest to the yeast community are listed below. If you would like to add a conference or meeting to list, please log in to the wiki. If you do not have a user account, please contact the [http://www.yeastgenome.org/cgi-bin/suggestion SGD helpdesk] and we will gladly create an account for you.

=Upcoming Conferences & Courses =

[http://www.biochem.emory.edu/serym2012/ 19th Annual Southeastern Regional Yeast Meeting] 
Emory University, Atlanta, GA 
February 24 - 26, 2012

[http://lmo10.insa-toulouse.fr/ 10th Francophone Yeasts Meeting, ''Levures, Modèle et Outils-10'' ] 
University of Toulouse, France 
April 2 - 4, 2012

[http://pir.georgetown.edu/biocuration2012/ Biocuration 2012 - The Conference of the International Society for Biocuration] 
Washington, DC 
April 2 - 4, 2012

[http://gm.asm.org/ General Meeting of the American Society for Microbiology] 
San Francisco, California 
June 16 - 19, 2012

[http://events.embo.org/12-transcription-yeast/index.html EMBO Conference 2012 on Gene Transcription in Yeast “From Mechanisms to Gene Regulatory Networks”] 
St. Feliu de Guíxols, Girona, Spain 
June 16-21, 2012

[http://www.mohb.org/2012/ Model Organisms to Human Biology: Cancer Genetics] 
Omni Shoreham, Washington, DC 
June 17 - 20, 2012

[https://secure.faseb.org/FASEB/meetings/summrconf/selectTopic.aspx?Sortfrom=2012 FASEB Conference: Yeast Chromosome Structure, Replication & Segregation] 
Steamboat Springs, Colorado 
July 15 - 20, 2012

[http://www.yeast-meet.org/2012/ Yeast Genetics 2012] 
Princeton University, New Jersey, USA 
July 31 - August 5, 2012

[http://www.icsb2012toronto.com The 13th International Conference on Systems Biology] 
Toronto, Canada 
August 19-23, 2012

[http://conferencing.uwex.edu/conferences/icy2012/index.cfm 13th International Congress on Yeasts] 
Madison, WI, USA 
August 26 - 30, 2012

[http://imya-2012.caspur.it/ 9th International Meeting on Yeast Apoptosis] 
Rome, Italy 
September 16 - 20, 2012

[http://www.embl.de/training/events/2012/EAE12-01/ Experimental Approaches to Evolution and Ecology using Yeast] 
EMBL Heidelberg, Germany 
October 17 - 21, 2012

[http://www.yeast-2013.org/ YEAST 2013: 26th International Conference on Yeast Genetics and Molecular Biology] 
Frankfurt University, Frankfurt, Germany 
August 29 - September 3, 2013

=Past Yeast Meetings=
International Conference on Yeast Genetics and Molecular Biology 
:Browse or search abstracts: 
:[http://www.yeast-2011.org/ 2011] (XXV) | 2009 (XXIV) | [http://www.yeastgenome.org/community/meetings/yeast07/ 2007] (XXIII) | [http://www.yeastgenome.org/community/meetings/yeast05/ 2005] (XXII) | [http://www.yeastgenome.org/community/meetings/yeast03/ 2003] (XXI) | [http://www.yeastgenome.org/community/meetings/yeast01/ 2001] (XX)

Yeast Genetics & Molecular Biology Meeting 
:Browse or search abstracts; view participant lists and photos: 
:[http://www.yeast-meet.org/2010/ 2010] | [http://www.yeast-meet.org/2008 2008] | [http://www.yeastgenome.org/community/meetings/yeast06/ 2006] | [http://www.yeastgenome.org/community/meetings/yeast04/ 2004] | [http://www.yeastgenome.org/community/meetings/yeast02/ 2002] | [http://www.yeastgenome.org/community/meetings/yeast00/ 2000] | [http://www.yeastgenome.org/community/meetings/yeast98/ 1998] | [http://www.yeastgenome.org/community/meetings/yeast96/ 1996]

Positions in yeast labs

2012-05-24T13:33:35Z

Marek:

=='''Postdoctoral Position in Chemical Genomics at RIKEN ASI'''==

Application due 6/1/12 for a foreign postdoctoral position at the RIKEN Advance Science Institute, Wako, Japan to work with yeast chemical genomics systems to characterize the targets of novel natural products from a large compound library using a diverse set of genomic and biochemical tools. The position is renewable for 3 years, and details can be found here: http://www.riken.jp/fpr/ Salary 487,000JPY per month. The successful candidate will work with the Molecular Ligand Target research team, headed by Dr. Charlie Boone within the lab of Dr. Minoru Yoshida. http://www.asi.riken.jp/en/laboratories/departments/cbd/chemical/ml-targ/index.html

For more information please contact Dr. Jeff Piotrowski j.piotrowski@riken.jp or Dr. Charlie Boone charlie.boone@utoronto.ca

=='''Bioinformatician at St Andrews University'''==
Bioinformatician - CD1173

Description:
School of Medicine, £30,122 - £35,938 pa, Start: As soon as possible,
Fixed-Term for 3 years in the first instance

Details:
An exciting opportunity for a Bioinformatician is available at the School
of Medicine at St Andrews University. You will join a dynamic and
multidisciplinary community and will play a key role in providing
specialist support to diverse projects across different research areas.
You will contribute to the development of a next generation sequence
analysis service to analyse and interpret data from deep sequencing
projects. Alongside provision of high quality support, a significant
contribution is expected towards the expansion of the service in scope and
staffing by increasing the number of users and attracting external funding.

You will have a degree in bio-computing, preferably to PhD level with
significant experience in bioinformatics. Advanced scripting and
experience in the analysis of genome scale biological datasets,
particularly high throughput sequencing data are required. We also
envisage a role in the installation/maintenance of bioinformatics
applications and provision of advice/training to users. Good
communications and management skills together with a clear vision of the
advances and progress in the field are essential.

The post will be available immediately for three years in first instance
and will be based at the School of Medicine.

Informal enquiries to Dr Silvia Paracchini, e-mail: sp58@st-andrews.ac.uk

Details and application via:
https://www.vacancies.st-andrews.ac.uk/welcome.aspx

Ref No: CD1173

Closing Date: 27 June 2012

=='''Laboratory Manager in Molecular Biology at Brown University'''==
March 2012: Position available in the laboratory of Tricia Serio, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI

The Laboratory Manager will have primary responsibility for managing the daily operation of the laboratory and for designing, conducting, and analyzing experiments to investigate cellular control of prion propagation in the yeast S. cerevisiae. The Laboratory Manager will also oversee and coordinate the activities of other laboratory personnel and the move of our laboratory to the Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ during the summer of 2012. The position will continue at the UA.

Position requirements:
• MA, MS, or PhD in molecular biology, genetics, cell biology, biochemistry or related field
• 3-5 years full-time laboratory experience
• Competence in laboratory techniques such as DNA isolation and cloning, PCR, RNA isolation, RT-PCR, protein isolation/purification, gel electrophoresis, western blotting, immunoprecipitation, fluorescence imaging and quantitative microscopy techniques including FRAP and FLIP); experience with yeast preferred but not required
• Excellent organizational/record-keeping skills
• Excellent hand/eye coordination
• Excellent interpersonal skills
• Competence with computer programs such as FileMaker, Microsoft Word and Excel, Adobe Photoshop and Illustrator
• Excellent quantitative skills
• Self-motivated

Applications should be submitted through Human Resources at Brown University:
https://careers.brown.edu/applicants/jsp/shared/frameset/Frameset.jsp?time=1332257367295
position # M02626

=='''PhD student in Molecular Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden'''==
A PhD student position in Molecular Biology/Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Experimental investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Here the experimental platform generated in the project will be optimized, especially the formation of cell arrays of synchronized cells as well as image analysis. Using in parallel Mig1 and Msn2 reporters, response thresholds under different glucose levels will be establish and effects on cell-to-cell variability and bistability will be determined.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signalling, use of microfluidic devices, microscopy, image analysis, application of nano-sensor technology, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

=='''PhD student in Systems Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden'''==

A PhD student position in Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Theoretical investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Data generated in the project will be interpreted by mathematical modelling together with other project partners to understand feedback and feed-forward mechanisms of signalling. Mutants and inhibitory compounds will be used to test how those affect thresholds and bistability. The analysis will reveal the genetic determination of the system properties, how they are regulated and how robustness against perturbation is established.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signaling, microscopy, image analysis, development of mathematical models, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

=='''Postdoctoral position to study Ty1 retrotransposition at the University of Georgia''' ==

A postdoctoral position is available in the lab of David J. Garfinkel, Department of Biochemistry and Molecular Biology, University of Georgia, Athens GA to work on the retrovirus-like transposon Ty1 of ''Saccharomyces''. Specifically, we are investigating a new form of RNA-interference based on Ty1 antisense RNAs that acts posttranslationally and targets Ty1 proteins in the absence of the conserved RNAi pathways.

Experience in molecular genetics, protein/nucleic acid interactions or cytology would be helpful.

Also see our website for further information [http://www.bmb.uga.edu/home/people/people.php?fname=David&lname=Garfinkel]

Please send resume or inquiries to:

David J. Garfinkel

Department of Biochemistry and Molecular Biology

A130 Life Sciences

120 Green St.

University of Georgia

Athens, GA 30622

tel: 706-542-9403

djgarf@bmb.uga.edu

==Yeast Systems Biology Position at Virginia Tech (Research Associate or Sr Research Associate)==
The Synthetic Biology group at Virginia Bioinformatics Institute (VBI) is involved in two collaborative research projects focused on the development of mathematical models of gene-protein regulatory networks controlling cell growth and division. Temporal organization of the budding yeast cell cycle has been studied from two vantage points: bottom-up models emphasize a protein regulatory network centered around cyclin-dependent protein kinases, whereas top-down models focus on a gene regulatory network governed by interrelated transcription factors. The first project is focused on unifying these two perspectives. The second project is focused on the development of stochastic models of the regulatory network controlling the cell cycle. Both projects are performed in close collaboration with experts in computer science, data mining, bioinformatics, and mathematical modeling. The successful candidate will be expected to contribute significantly to these two projects by being responsible for designing and performing experiments used to validate model predictions. These experiments will involve the development of a new collection of cell cycle mutants and their quantitative characterization by time-lapse microscopy. In addition, the successful candidate will be expected to prepare the results for publication and presentation, to help supervise graduate and undergraduate students, and to contribute to grant proposals.

Dependent on the qualifications of the successful candidate, the position will hold the research faculty rank of either Research Associate or Senior Research Associate.

Go to the [http://bit.ly/n4nDUQ position description] for additional information and for submitting applications.

More information about our team can be found by visiting:
* [http://www.vbi.vt.edu/faculty/personal/Jean_Peccoud Jean Peccoud's home page]
* [http://www.biol.vt.edu/faculty/tyson/ John Tyson's home page]
* [https://bioinformatics.cs.vt.edu/~murali/ T.M. Murali's home page]

==Postdoctoral grants at the Max Planck Institute for Evolutionary Biology, Plön, Germany==
Post-doctoral grants are available for ambitious, motivated scientists to join Experimental Evolution Research Group. We can provide excellent research funding and support for projects that build on or complement our existing program. Positions are funded by the Max Planck Society for 2 years initially.

We use Saccharomyces yeasts as model organisms for evolution and ecology. ''Saccharomyces cerevisiae'' is probably the best known and most tractable model organism used in biology, but its life outside the laboratory is poorly understood. We study the evolution of various interesting yeast traits using both laboratory experiments and observations of wild yeast. For a primer on yeast evolutionary biology, and to understand the motivation for our research please read Greig, D. & Leu, J-Y. (2009) “Natural history of budding yeast” Curr. Biol. 19:R886-890. For our current work, please see our [http://www.evolbio.mpg.de/expevolution/Greig/Welcome.html lab web page]

The Max Planck Institute for Evolutionary Biology offers outstanding infrastructure and facilities, and is attractively located in Northern Germany, in a lake district near the Baltic coast. It is well connected by train to the university towns of Lübeck and Kiel, and Hamburg is the nearest major airport.

Applicants must have a PhD and at least one peer-reviewed publication in the field of evolution, ecology, or yeast genetics. Applicants should prepare a short (<500 word) research proposal, a CV, and contact details for three academic referees. They should combine these into a single PDF file and send it by email to Duncan Greig (d.greig@evolbio.mpg.de). Informal enquiries can be made to any member of the Research Group. Applications will be considered until suitable candidates are found. September 2011

==Postdoctoral position==
SEPTEMBER 2011: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California).

Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease.

The position available is to elucidate the functions and mechanisms of the E3 ligase LISTERIN. We had previously reported on a new mouse model of neurodegeneration caused by mutation of Listerin/Ltn1, a novel E3 (Chu et al. 2009). Homozygous mutant mice exhibit profound early-onset and progressive neurological and motor dysfunction. The focus of our most recent work has been on elucidating this E3’s critical biological role(s) and determining how defects in its function lead to the disease. Listerin/Ltn1 is conserved in all eukaryotes, so we have taken advantage of budding yeast and found that the E3 is ribosome-associated and functions in the quality control of a specific subset of aberrant, nascent proteins (Bengtson & Joazeiro 2010). Currently, we undertake biochemistry, yeast genetics, mammalian tissue culture and genomic approaches to continue our characterization of Listerin/Ltn1, and are positioned to readily test the relevance of the discoveries we make for neurodegeneration using the mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Selected references:
*Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467:470-3.
*Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem. 78:399-434.
*Chu J et al. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. PNAS 106:2097-103.

The candidate should be independent, hard working, proactive and productive, and should have strong conceptual and experimental background in biochemistry and molecular biology.

Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to: 
Claudio Joazeiro 
c/o Miriam Berba (Email: mirberba@scripps.edu) 
The Scripps Research Institute, CB-163 
10550 N Torrey Pines Rd 
La Jolla, CA 92037 USA

==Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France==
Postdoctoral position is available in the Laboratory of Cell Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the fission yeast S. pombe. The roles of the Rho GTPase, actin polymerisation, and myosin will be studied. The work will involve genetics, cell biology, microscopy, microfabrication and microfluidics; for more information, send a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

Positions in yeast labs

2012-05-23T13:33:27Z

Marek:

=='''Bioinformatician at St Andrews University'''==
Bioinformatician - CD1173

Description:
School of Medicine, £30,122 - £35,938 pa, Start: As soon as possible,
Fixed-Term for 3 years in the first instance

Details:
An exciting opportunity for a Bioinformatician is available at the School
of Medicine at St Andrews University. You will join a dynamic and
multidisciplinary community and will play a key role in providing
specialist support to diverse projects across different research areas.
You will contribute to the development of a next generation sequence
analysis service to analyse and interpret data from deep sequencing
projects. Alongside provision of high quality support, a significant
contribution is expected towards the expansion of the service in scope and
staffing by increasing the number of users and attracting external funding.

You will have a degree in bio-computing, preferably to PhD level with
significant experience in bioinformatics. Advanced scripting and
experience in the analysis of genome scale biological datasets,
particularly high throughput sequencing data are required. We also
envisage a role in the installation/maintenance of bioinformatics
applications and provision of advice/training to users. Good
communications and management skills together with a clear vision of the
advances and progress in the field are essential.

The post will be available immediately for three years in first instance
and will be based at the School of Medicine.

Informal enquiries to Dr Silvia Paracchini, e-mail: sp58@st-andrews.ac.uk

Details and application via:
https://www.vacancies.st-andrews.ac.uk/welcome.aspx

Ref No: CD1173

Closing Date: 27 June 2012

=='''Laboratory Manager in Molecular Biology at Brown University'''==
March 2012: Position available in the laboratory of Tricia Serio, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI

The Laboratory Manager will have primary responsibility for managing the daily operation of the laboratory and for designing, conducting, and analyzing experiments to investigate cellular control of prion propagation in the yeast S. cerevisiae. The Laboratory Manager will also oversee and coordinate the activities of other laboratory personnel and the move of our laboratory to the Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ during the summer of 2012. The position will continue at the UA.

Position requirements:
• MA, MS, or PhD in molecular biology, genetics, cell biology, biochemistry or related field
• 3-5 years full-time laboratory experience
• Competence in laboratory techniques such as DNA isolation and cloning, PCR, RNA isolation, RT-PCR, protein isolation/purification, gel electrophoresis, western blotting, immunoprecipitation, fluorescence imaging and quantitative microscopy techniques including FRAP and FLIP); experience with yeast preferred but not required
• Excellent organizational/record-keeping skills
• Excellent hand/eye coordination
• Excellent interpersonal skills
• Competence with computer programs such as FileMaker, Microsoft Word and Excel, Adobe Photoshop and Illustrator
• Excellent quantitative skills
• Self-motivated

Applications should be submitted through Human Resources at Brown University:
https://careers.brown.edu/applicants/jsp/shared/frameset/Frameset.jsp?time=1332257367295
position # M02626

=='''PhD student in Molecular Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden'''==
A PhD student position in Molecular Biology/Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Experimental investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Here the experimental platform generated in the project will be optimized, especially the formation of cell arrays of synchronized cells as well as image analysis. Using in parallel Mig1 and Msn2 reporters, response thresholds under different glucose levels will be establish and effects on cell-to-cell variability and bistability will be determined.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signalling, use of microfluidic devices, microscopy, image analysis, application of nano-sensor technology, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

=='''PhD student in Systems Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden'''==

A PhD student position in Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Theoretical investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Data generated in the project will be interpreted by mathematical modelling together with other project partners to understand feedback and feed-forward mechanisms of signalling. Mutants and inhibitory compounds will be used to test how those affect thresholds and bistability. The analysis will reveal the genetic determination of the system properties, how they are regulated and how robustness against perturbation is established.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signaling, microscopy, image analysis, development of mathematical models, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

=='''Postdoctoral position to study Ty1 retrotransposition at the University of Georgia''' ==

A postdoctoral position is available in the lab of David J. Garfinkel, Department of Biochemistry and Molecular Biology, University of Georgia, Athens GA to work on the retrovirus-like transposon Ty1 of ''Saccharomyces''. Specifically, we are investigating a new form of RNA-interference based on Ty1 antisense RNAs that acts posttranslationally and targets Ty1 proteins in the absence of the conserved RNAi pathways.

Experience in molecular genetics, protein/nucleic acid interactions or cytology would be helpful.

Also see our website for further information [http://www.bmb.uga.edu/home/people/people.php?fname=David&lname=Garfinkel]

Please send resume or inquiries to:

David J. Garfinkel

Department of Biochemistry and Molecular Biology

A130 Life Sciences

120 Green St.

University of Georgia

Athens, GA 30622

tel: 706-542-9403

djgarf@bmb.uga.edu

==Yeast Systems Biology Position at Virginia Tech (Research Associate or Sr Research Associate)==
The Synthetic Biology group at Virginia Bioinformatics Institute (VBI) is involved in two collaborative research projects focused on the development of mathematical models of gene-protein regulatory networks controlling cell growth and division. Temporal organization of the budding yeast cell cycle has been studied from two vantage points: bottom-up models emphasize a protein regulatory network centered around cyclin-dependent protein kinases, whereas top-down models focus on a gene regulatory network governed by interrelated transcription factors. The first project is focused on unifying these two perspectives. The second project is focused on the development of stochastic models of the regulatory network controlling the cell cycle. Both projects are performed in close collaboration with experts in computer science, data mining, bioinformatics, and mathematical modeling. The successful candidate will be expected to contribute significantly to these two projects by being responsible for designing and performing experiments used to validate model predictions. These experiments will involve the development of a new collection of cell cycle mutants and their quantitative characterization by time-lapse microscopy. In addition, the successful candidate will be expected to prepare the results for publication and presentation, to help supervise graduate and undergraduate students, and to contribute to grant proposals.

Dependent on the qualifications of the successful candidate, the position will hold the research faculty rank of either Research Associate or Senior Research Associate.

Go to the [http://bit.ly/n4nDUQ position description] for additional information and for submitting applications.

More information about our team can be found by visiting:
* [http://www.vbi.vt.edu/faculty/personal/Jean_Peccoud Jean Peccoud's home page]
* [http://www.biol.vt.edu/faculty/tyson/ John Tyson's home page]
* [https://bioinformatics.cs.vt.edu/~murali/ T.M. Murali's home page]

==Postdoctoral grants at the Max Planck Institute for Evolutionary Biology, Plön, Germany==
Post-doctoral grants are available for ambitious, motivated scientists to join Experimental Evolution Research Group. We can provide excellent research funding and support for projects that build on or complement our existing program. Positions are funded by the Max Planck Society for 2 years initially.

We use Saccharomyces yeasts as model organisms for evolution and ecology. ''Saccharomyces cerevisiae'' is probably the best known and most tractable model organism used in biology, but its life outside the laboratory is poorly understood. We study the evolution of various interesting yeast traits using both laboratory experiments and observations of wild yeast. For a primer on yeast evolutionary biology, and to understand the motivation for our research please read Greig, D. & Leu, J-Y. (2009) “Natural history of budding yeast” Curr. Biol. 19:R886-890. For our current work, please see our [http://www.evolbio.mpg.de/expevolution/Greig/Welcome.html lab web page]

The Max Planck Institute for Evolutionary Biology offers outstanding infrastructure and facilities, and is attractively located in Northern Germany, in a lake district near the Baltic coast. It is well connected by train to the university towns of Lübeck and Kiel, and Hamburg is the nearest major airport.

Applicants must have a PhD and at least one peer-reviewed publication in the field of evolution, ecology, or yeast genetics. Applicants should prepare a short (<500 word) research proposal, a CV, and contact details for three academic referees. They should combine these into a single PDF file and send it by email to Duncan Greig (d.greig@evolbio.mpg.de). Informal enquiries can be made to any member of the Research Group. Applications will be considered until suitable candidates are found. September 2011

==Postdoctoral position==
SEPTEMBER 2011: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California).

Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease.

The position available is to elucidate the functions and mechanisms of the E3 ligase LISTERIN. We had previously reported on a new mouse model of neurodegeneration caused by mutation of Listerin/Ltn1, a novel E3 (Chu et al. 2009). Homozygous mutant mice exhibit profound early-onset and progressive neurological and motor dysfunction. The focus of our most recent work has been on elucidating this E3’s critical biological role(s) and determining how defects in its function lead to the disease. Listerin/Ltn1 is conserved in all eukaryotes, so we have taken advantage of budding yeast and found that the E3 is ribosome-associated and functions in the quality control of a specific subset of aberrant, nascent proteins (Bengtson & Joazeiro 2010). Currently, we undertake biochemistry, yeast genetics, mammalian tissue culture and genomic approaches to continue our characterization of Listerin/Ltn1, and are positioned to readily test the relevance of the discoveries we make for neurodegeneration using the mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Selected references:
*Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467:470-3.
*Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem. 78:399-434.
*Chu J et al. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. PNAS 106:2097-103.

The candidate should be independent, hard working, proactive and productive, and should have strong conceptual and experimental background in biochemistry and molecular biology.

Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to: 
Claudio Joazeiro 
c/o Miriam Berba (Email: mirberba@scripps.edu) 
The Scripps Research Institute, CB-163 
10550 N Torrey Pines Rd 
La Jolla, CA 92037 USA

==Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France==
Postdoctoral position is available in the Laboratory of Cell Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the fission yeast S. pombe. The roles of the Rho GTPase, actin polymerisation, and myosin will be studied. The work will involve genetics, cell biology, microscopy, microfabrication and microfluidics; for more information, send a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

Meetings

2012-02-29T13:12:51Z

Marek: /* Upcoming Conferences & Courses */

Meetings that may be of interest to the yeast community are listed below. If you would like to add a conference or meeting to list, please log in to the wiki. If you do not have a user account, please contact the [http://www.yeastgenome.org/cgi-bin/suggestion SGD helpdesk] and we will gladly create an account for you.

=Upcoming Conferences & Courses =

[http://www.biochem.emory.edu/serym2012/ 19th Annual Southeastern Regional Yeast Meeting] 
Emory University, Atlanta, GA 
February 24 - 26, 2012

[http://lmo10.insa-toulouse.fr/ 10th Francophone Yeasts Meeting, ''Levures, Modèle et Outils-10'' ] 
University of Toulouse, France 
April 2 - 4, 2012

[http://pir.georgetown.edu/biocuration2012/ Biocuration 2012 - The Conference of the International Society for Biocuration] 
Washington, DC 
April 2 - 4, 2012

[http://gm.asm.org/ General Meeting of the American Society for Microbiology] 
San Francisco, California 
June 16 - 19, 2012

[http://events.embo.org/12-transcription-yeast/index.html EMBO Conference 2012 on Gene Transcription in Yeast “From Mechanisms to Gene Regulatory Networks”] 
St. Feliu de Guíxols, Girona, Spain 
June 16-21, 2012

[http://www.mohb.org/2012/ Model Organisms to Human Biology: Cancer Genetics] 
Omni Shoreham, Washington, DC 
June 17 - 20, 2012

[https://secure.faseb.org/FASEB/meetings/summrconf/selectTopic.aspx?Sortfrom=2012 FASEB Conference: Yeast Chromosome Structure, Replication & Segregation] 
Steamboat Springs, Colorado 
July 15 - 20, 2012

[http://www.yeast-meet.org/2012/ Yeast Genetics 2012] 
Princeton University, New Jersey, USA 
July 31 - August 5, 2012

[http://conferencing.uwex.edu/conferences/icy2012/index.cfm 13th International Congress on Yeasts] 
Madison, WI, USA 
August 26 - 30, 2012

[http://imya-2012.caspur.it/ 9th International Meeting on Yeast Apoptosis] 
Rome, Italy 
September 16 - 20, 2012

[http://www.embl.de/training/events/2012/EAE12-01/ Experimental Approaches to Evolution and Ecology using Yeast] 
EMBL Heidelberg, Germany 
October 17 - 21, 2012

[http://www.yeast-2013.org/ YEAST 2013: 26th International Conference on Yeast Genetics and Molecular Biology] 
Frankfurt University, Frankfurt, Germany 
August 29 - September 3, 2013

=Past Yeast Meetings=
International Conference on Yeast Genetics and Molecular Biology 
:Browse or search abstracts: 
:[http://www.yeast-2011.org/ 2011] (XXV) | 2009 (XXIV) | [http://www.yeastgenome.org/community/meetings/yeast07/ 2007] (XXIII) | [http://www.yeastgenome.org/community/meetings/yeast05/ 2005] (XXII) | [http://www.yeastgenome.org/community/meetings/yeast03/ 2003] (XXI) | [http://www.yeastgenome.org/community/meetings/yeast01/ 2001] (XX)

Yeast Genetics & Molecular Biology Meeting 
:Browse or search abstracts; view participant lists and photos: 
:[http://www.yeast-meet.org/2010/ 2010] | [http://www.yeast-meet.org/2008 2008] | [http://www.yeastgenome.org/community/meetings/yeast06/ 2006] | [http://www.yeastgenome.org/community/meetings/yeast04/ 2004] | [http://www.yeastgenome.org/community/meetings/yeast02/ 2002] | [http://www.yeastgenome.org/community/meetings/yeast00/ 2000] | [http://www.yeastgenome.org/community/meetings/yeast98/ 1998] | [http://www.yeastgenome.org/community/meetings/yeast96/ 1996]

Meetings

2012-02-29T13:10:42Z

Marek: /* Upcoming Conferences & Courses */

Meetings that may be of interest to the yeast community are listed below. If you would like to add a conference or meeting to list, please log in to the wiki. If you do not have a user account, please contact the [http://www.yeastgenome.org/cgi-bin/suggestion SGD helpdesk] and we will gladly create an account for you.

=Upcoming Conferences & Courses =

[http://events.embo.org/12-transcription-yeast/index.html EMBO Conference 2012 on Gene Transcription in Yeast “From Mechanisms to Gene Regulatory Networks”] 
St. Feliu de Guíxols, Girona, Spain 
June 16-21, 2012

[http://www.biochem.emory.edu/serym2012/ 19th Annual Southeastern Regional Yeast Meeting] 
Emory University, Atlanta, GA 
February 24 - 26, 2012

[http://lmo10.insa-toulouse.fr/ 10th Francophone Yeasts Meeting, ''Levures, Modèle et Outils-10'' ] 
University of Toulouse, France 
April 2 - 4, 2012

[http://pir.georgetown.edu/biocuration2012/ Biocuration 2012 - The Conference of the International Society for Biocuration] 
Washington, DC 
April 2 - 4, 2012

[http://gm.asm.org/ General Meeting of the American Society for Microbiology] 
San Francisco, California 
June 16 - 19, 2012

[http://www.mohb.org/2012/ Model Organisms to Human Biology: Cancer Genetics] 
Omni Shoreham, Washington, DC 
June 17 - 20, 2012

[https://secure.faseb.org/FASEB/meetings/summrconf/selectTopic.aspx?Sortfrom=2012 FASEB Conference: Yeast Chromosome Structure, Replication & Segregation] 
Steamboat Springs, Colorado 
July 15 - 20, 2012

[http://www.yeast-meet.org/2012/ Yeast Genetics 2012] 
Princeton University, New Jersey, USA 
July 31 - August 5, 2012

[http://conferencing.uwex.edu/conferences/icy2012/index.cfm 13th International Congress on Yeasts] 
Madison, WI, USA 
August 26 - 30, 2012

[http://imya-2012.caspur.it/ 9th International Meeting on Yeast Apoptosis] 
Rome, Italy 
September 16 - 20, 2012

[http://www.embl.de/training/events/2012/EAE12-01/ Experimental Approaches to Evolution and Ecology using Yeast] 
EMBL Heidelberg, Germany 
October 17 - 21, 2012

[http://www.yeast-2013.org/ YEAST 2013: 26th International Conference on Yeast Genetics and Molecular Biology] 
Frankfurt University, Frankfurt, Germany 
August 29 - September 3, 2013

=Past Yeast Meetings=
International Conference on Yeast Genetics and Molecular Biology 
:Browse or search abstracts: 
:[http://www.yeast-2011.org/ 2011] (XXV) | 2009 (XXIV) | [http://www.yeastgenome.org/community/meetings/yeast07/ 2007] (XXIII) | [http://www.yeastgenome.org/community/meetings/yeast05/ 2005] (XXII) | [http://www.yeastgenome.org/community/meetings/yeast03/ 2003] (XXI) | [http://www.yeastgenome.org/community/meetings/yeast01/ 2001] (XX)

Yeast Genetics & Molecular Biology Meeting 
:Browse or search abstracts; view participant lists and photos: 
:[http://www.yeast-meet.org/2010/ 2010] | [http://www.yeast-meet.org/2008 2008] | [http://www.yeastgenome.org/community/meetings/yeast06/ 2006] | [http://www.yeastgenome.org/community/meetings/yeast04/ 2004] | [http://www.yeastgenome.org/community/meetings/yeast02/ 2002] | [http://www.yeastgenome.org/community/meetings/yeast00/ 2000] | [http://www.yeastgenome.org/community/meetings/yeast98/ 1998] | [http://www.yeastgenome.org/community/meetings/yeast96/ 1996]

Meetings

2012-02-29T13:10:16Z

Marek: /* Upcoming Conferences & Courses */

Meetings that may be of interest to the yeast community are listed below. If you would like to add a conference or meeting to list, please log in to the wiki. If you do not have a user account, please contact the [http://www.yeastgenome.org/cgi-bin/suggestion SGD helpdesk] and we will gladly create an account for you.

=Upcoming Conferences & Courses =

[http://events.embo.org/12-transcription-yeast/index.html EMBO Conference 2012 on Gene Transcription in Yeast “From Mechanisms to Gene Regulatory Networks”] 
St. Feliu de Guíxols, Girona, Spain 
16-21 June 2012

[http://www.biochem.emory.edu/serym2012/ 19th Annual Southeastern Regional Yeast Meeting] 
Emory University, Atlanta, GA 
February 24 - 26, 2012

[http://lmo10.insa-toulouse.fr/ 10th Francophone Yeasts Meeting, ''Levures, Modèle et Outils-10'' ] 
University of Toulouse, France 
April 2 - 4, 2012

[http://pir.georgetown.edu/biocuration2012/ Biocuration 2012 - The Conference of the International Society for Biocuration] 
Washington, DC 
April 2 - 4, 2012

[http://gm.asm.org/ General Meeting of the American Society for Microbiology] 
San Francisco, California 
June 16 - 19, 2012

[http://www.mohb.org/2012/ Model Organisms to Human Biology: Cancer Genetics] 
Omni Shoreham, Washington, DC 
June 17 - 20, 2012

[https://secure.faseb.org/FASEB/meetings/summrconf/selectTopic.aspx?Sortfrom=2012 FASEB Conference: Yeast Chromosome Structure, Replication & Segregation] 
Steamboat Springs, Colorado 
July 15 - 20, 2012

[http://www.yeast-meet.org/2012/ Yeast Genetics 2012] 
Princeton University, New Jersey, USA 
July 31 - August 5, 2012

[http://conferencing.uwex.edu/conferences/icy2012/index.cfm 13th International Congress on Yeasts] 
Madison, WI, USA 
August 26 - 30, 2012

[http://imya-2012.caspur.it/ 9th International Meeting on Yeast Apoptosis] 
Rome, Italy 
September 16 - 20, 2012

[http://www.embl.de/training/events/2012/EAE12-01/ Experimental Approaches to Evolution and Ecology using Yeast] 
EMBL Heidelberg, Germany 
October 17 - 21, 2012

[http://www.yeast-2013.org/ YEAST 2013: 26th International Conference on Yeast Genetics and Molecular Biology] 
Frankfurt University, Frankfurt, Germany 
August 29 - September 3, 2013

=Past Yeast Meetings=
International Conference on Yeast Genetics and Molecular Biology 
:Browse or search abstracts: 
:[http://www.yeast-2011.org/ 2011] (XXV) | 2009 (XXIV) | [http://www.yeastgenome.org/community/meetings/yeast07/ 2007] (XXIII) | [http://www.yeastgenome.org/community/meetings/yeast05/ 2005] (XXII) | [http://www.yeastgenome.org/community/meetings/yeast03/ 2003] (XXI) | [http://www.yeastgenome.org/community/meetings/yeast01/ 2001] (XX)

Yeast Genetics & Molecular Biology Meeting 
:Browse or search abstracts; view participant lists and photos: 
:[http://www.yeast-meet.org/2010/ 2010] | [http://www.yeast-meet.org/2008 2008] | [http://www.yeastgenome.org/community/meetings/yeast06/ 2006] | [http://www.yeastgenome.org/community/meetings/yeast04/ 2004] | [http://www.yeastgenome.org/community/meetings/yeast02/ 2002] | [http://www.yeastgenome.org/community/meetings/yeast00/ 2000] | [http://www.yeastgenome.org/community/meetings/yeast98/ 1998] | [http://www.yeastgenome.org/community/meetings/yeast96/ 1996]

Positions in yeast labs

2011-07-28T15:10:01Z

Marek:

==Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France==
Postdoctoral position is available in the Laboratory of Cell
Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the
fission yeast S. pombe. The roles of the Rho GTPase, actin
polymerisation, and myosin will be studied. The work will involve
genetics, cell biology, microscopy, microfabrication and
microfluidics; for more information, send a CV and contact information
of referees to Dr. Daniel Riveline (riveline@unistra.fr)

==Technician Position - Yeast Cell Biology - London UK==
A research technician position is available in the Thorpe lab at the MRC National Institute for Medical Research, Mill Hill, London (http://www.nimr.mrc.ac.uk/research/peter-thorpe/). The lab uses the yeast, ''Saccharomyces cerevisiae'' to study fundamental aspects of cell division. The project is focussed upon identifying the molecular pathways that control asymmetric cell division. We employ a combination of yeast genomics approaches and high-throughput fluorescence microscopy to identify the genes responsible for asymmetry in yeast. The work involves supporting the goals of the lab and will include yeast genetics, genomics, fluorescence imaging and image analysis. Preference will be given to candidates with strong computer-based skills including the use of standard office software, DNA sequence analysis, database management and image analysis.

Applications are handled by the RCUK Shared Services Centre; to apply please visit the job board at https://ext.ssc.rcuk.ac.uk and complete an online application form. Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003. Please quote reference number IRC23869.

Closing date for applications is 4th July, 2011.

==Yeast quantitative genetics post-doctoral positions at Duke University Medical Center==
Positions are available for post-docs to work on a recently NIH funded grant “High throughput S. cerevisiae HAM, GWA & QT/QTL architecture resource”. Our understanding of quantitative traits, which includes pharmacogenetic variations in human drug efficacy and side effects, is poor. Improving our understanding of quantitative traits and of pharmacogenetics is aided by tractable model systems, such as Saccharomyces cerevisiae. In this study, we develop a novel S. cerevisiae genetic resource population for high throughput haploid association mapping (HAM) and genome wide association (GWA).

We will use the high quality genome sequences of 96 S. cerevisiae strains to generate a novel genetic resource population that we will use to perform high throughput determination of quantitative trait (QT) and quantitative trait loci (QTL) architecture. Start dates are open. Candidates should have recently received their Ph.D. (0 to – at most – 4 years) and should have expertise in yeast genetics/molecular biology and/or quantitative/population genetics. Candidates should email their curriculum vitae (pdf), including the names and contact information for three references, to John McCusker at mccus001@mc.duke.edu.

Positions in yeast labs

2009-08-06T16:20:33Z

Marek: /* Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge */

= Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge=

Postdoctoral Research Associate in the group of Dr Janneke Balk, Department of Plant Sciences, University of Cambridge

Salary: £27,183-£35,469 pa Limit of tenure: grant funding is available for 3 years in the first instance. Start date: 1 January 2010

Applicants must have a PhD, and a background in fungal genetics will be highly preferred. Previous experience in molecular biology and biochemistry methods is essential. This project is funded by the Wellcome Trust and includes part-time technical assistance.

The assembly of iron-sulphur cofactors in respiratory complex I

Complex I deficiencies are the most common cause of respiratory chain dysfunction, but how this largest of the respiratory complexes is assembled, including its unique chain of eight iron-sulphur (Fe-S) clusters, is poorly understood. This project aims to investigate the assembly of complex I using the yeast Yarrowia lipolytica as a genetic model organism, and will focus on: 1) Further analysis of the molecular role of Ind1, a recently identified Fe-S scaffold protein important for complex I assembly in Yarrowia and human cell lines (Bych et al 2008; Sheftel et al, unpublished). 2) Development of Yarrowia yeast as a genetic model organism to perform forward genetics screens, complemented by a biochemical approach, to identify additional complex I assembly factors, in particular those that assist Ind1 with Fe-S cluster insertion. 3) Translation of the findings to human disease: identification of human orthologues and whether they are implicated in complex I disorders.

This project involves collaborations with Dr Judy Hirst at the MRC Cambridge (in vitro cluster assembly in complex I subunits), Professor Ulrich Brandt, Frankfurt (complex I function and genetics in Yarrowia yeast) and Professor Jan Smeitink, Nijmegen (translation of the findings to human respiratory disease).

Dr Janneke Balk started an independent research group in 2005, focussing on Fe-S protein biogenesis in (higher) eukaryotes. Her dynamic and international group is rapidly expanding and moving to new laboratory space this autumn.

The University of Cambridge is a world-class research institute, which is particulary strong in biomedical sciences.

Reference: Bych K, Kerscher S, Netz DJA, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U and Balk, J (2008). The iron-sulfur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736-46.

For further enqueries: Janneke Balk, jb511@cam.ac.uk To apply, see http://www.plantsci.cam.ac.uk/jobs/content.html

=Postdoctoral Position at University of Texas Health Science Center at San Antonio=

A postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine morphology and virulence of ''Candida albicans'', the major fungal pathogen, in response to host environmental cues (for additional details see Carlisle, et al., PNAS 106:599-604 (2009)[http://www.pnas.org/content/106/2/599.long], Banerjee et al., MBC 19:1354-1365 (2008)[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18216277] and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis.

Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis, as well as ''S. cerevisiae'' researchers interested in transitioning to fungal pathogenesis, are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu).

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

=Postdoctoral or Staff Scientist Position at Purdue University=

Postdoctoral/Staff scientist position available in yeast functional genomics of chromosome segregation at Purdue University. Project goals are to define, on a global scale, the effect of phosphorylation by the Aurora kinase on protein interactions controlling chromosome segregation process in yeast. Project is funded for up to five years by NIH and will involve high-throughput screening and lab automation, genome-wide studies, microscopy, yeast molecular biology and bioinformatic analysis. Applicants should have a recent PhD in any field of biology that includes a strong conceptual and experimental background in Genetics, and/or Molecular and Cell Biology.

Applicants should send a CV by email to Dr. Tony Hazbun listed at the following web site:
http://www.mcmp.purdue.edu/faculty/?uid=hazbun

=Postdoctoral Position at Rutgers University=

A postdoctoral position is available at the Biotech Center at Rutgers University in the laboratory of Dr. Nilgun E. Tumer to investigate the mechanisms of uptake, transport and cytotoxicity of ricin and Shiga-like toxins. The Tumer lab works on elucidating the basic mechanisms of action of ricin and Shiga-like toxins using Saccharomyces cerevisae and C. elegans as model systems. Both toxins depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. Our goal is to identify the targets of these toxins to understand the mechanism by which they kill cells and to develop therapeutic intervention strategies. The successful candidate will use genetic, cell biology and chemical genomic approaches to investigate the mechanism of uptake and transport of the toxins in yeast and C. elegans and use chemical genomics approaches to identify the cellular pathways affected by these toxins. The ideal candidate should have a Ph.D. in a related field, experience with yeast and/or C.elegans genetics and cell biology and familiarity with chemical biology approaches. The Biotech Center is located in New Brunswick, New Jersey near New York City and Philadelphia and is equipped with state-of-the-art facilities and instrumentation. Rutgers University is an equal opportunity employer that strongly encourages underrepresented groups to apply for open positions.

Interested applicants should send their CV and names and addresses of three references to Dr. Nilgun E. Tumer (tumer@aesop.rutgers.edu). Information on our research can be found at: http://biotech.rutgers.edu/faculty/tumer.html, http://aesop.rutgers.edu/~plantbiopath/faculty/tumer/TUMER.HTML, http://lifesci.rutgers.edu/~molbiosci/faculty/tumer.html
Contact: Nilgun Tumer, Foran Hall, Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520. Tel: 732-932-8165 X215.

=Postdoctoral Position, Chemical Genomics=

Research Department: Molecular Ligand Target Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute
Dr. Charles Boone, Visiting Scientist
Dr. Minoru Yoshida, Team Leader

Location: RIKEN Advanced Science Institute, RIKEN Wako Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan

Area of Research: Chemical genetics and chemical genomics

Job Description: A postdoctoral researcher position is open in the field of chemical genomics. We have constructed a unique chemical library based on natural products in the Department of Chemical Biology, RIKAN Advanced Science Institute. The successful candidate will carry out original research on global analysis of drug-target interaction using the chemical library and various yeast mutants or transformants.

Selection Process: Candidates will be selected based on research results, publications, letters of recommendation (preferably in English), etc. The CV (preferably detailed and complete) and publications must be in English.

Application Deadline: Applications are now being accepted. Position will be closed after a suitable candidate is found.

Start of Employment: Immediately

Contract Conditions: Full-time employment with the contract shall be for one year, renewable annually upon evaluation until the end of the project (March 2012). Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Moving expenses to RIKEN will be reimbursed. Social insurance will also be applicable. Days off include public holidays, New Year's holidays (Dec. 29-Jan 3), summer holidays and RIKEN Foundation Day. These and other employment provisions are in accordance with RIKEN regulations.

Information at Web: Information on our team can be found on our website (http://www.riken.go.jp/engn/r-world/research/lab/asi/chemical/index.html)

Applications: Electronic copies of your curriculum vitae/résumé, a list of publications, two or three representative publications, and two reference letters should be sent to the address below or via e-mail to "charlie.boone" (add @utoronto.ca" to complete the address):
Charles Boone
Professor, University of Toronto, Donnelly CCBR
160 College St, Rm 1306
Toronto, ON
M5S 3E1

Notes: The documents you submit will be handled with the utmost care in accordance with RIKEN's rules for the protection of personal data and will be used only for employment screening purposes. This information will not be divulged, assigned, or loaned to a third party without legitimate reason.

=Postdoctoral Position: Engineering sea lamprey antibodies=

A vacant postdoctoral position at the Center of Marine Biotechnology in Baltimore to characterize antigen binding properties of VLR, the unique variable lymphocyte receptors of sea lamprey. The successful candidate will join a study with the goal to explore biotechnology applications for these novel antibodies (Pancer & Mariuzza, Nat. Biotechnol., 2008; Rogozin et al., Nat. Immunol., 2007; Alder et al., Science 2005; Pancer et al., Nature 2004). Our research platform includes yeast displayed recombinant VLR libraries that are screened with various antigens. Biochemical and structural properties of monoclonal VLRs are then characterized.

Candidates must have a PhD with solid background in protein biochemistry and molecular biology, experience in recombinant protein expression and characterization, and relevant peer-reviewed publications.

To apply for position #300957 please submit a letter describing your research interests and experience, an updated curriculum vitae and names of three references via http://www.cytiva.com/umbi/ext/detail.asp?jobid=umbi300957

Contact: Zeev Pancer, PhD
Center of Marine Biotechnology, UMBI
Columbus Center, Suite 236
701 East Pratt St. Baltimore, MD 21202, USA
Office: 410-234-8834; Fax: 410-234-8896
Email: pancer@comb.umbi.umd.edu

=Epigenetic Postdoctoral Fellow Posting=

'''Postdoctoral positions''' are available at Massachusetts General Hospital Cancer Center. My laboratory is focused on understanding the impact that both methylation and acetylation dynamics has in both human cell culture and C. elegans. In particular, the laboratory is investigating the impact that the histone 3 lysine 9/36 tri-demethylases [JMJD2A-D; Whetstine et al., (2007) Cell 125: 467-81] have on tumorigenesis, transcriptional regulation, and genomic integrity. The laboratory will interrogate the role of these enzymes by using genomic, proteomic, cytological and genetic approaches. Similar approaches allowed an important link to be established for histone deacetylase 1 (HDAC-1) and the regulation of extra-cellular matrix biology in both human and C. elegans, which has direct implications in cancer chemotherapy [Whetstine et al., (2005) Mol. Cell 18:483-90]. The laboratory will continue to investigate the functional overlap or unique pathways that the C. elegans class I histone deacetylases regulate by using the same type of approaches. Overall, the laboratory will integrate a number of approaches and systems to determine the important biological pathways regulated by histone demethylases and histone deacetylases.

The laboratory is looking for highly motivated, tenacious scientists that are enthusiastic, team players and love science. The laboratory is looking for researchers with documented proficiency in any of the following areas (basic molecular biology, protein biochemistry, genomics, epigenetics, C. elegans, cytology, development biology, DNA damage and repair) but interested in learning new approaches or systems to answer the exciting questions before us.

Requirements:
For these positions a Ph.D. and/or M.D. is required. These positions require enthusiastic, self motivated, independent thinkers with strong interpersonal skills, and the ability to communicate with laboratory members, national and international collaborators. Please have three letters of recommendation sent to the below address and/or e-mail.

Johnathan R. Whetstine, Ph.D.
Assistant Professor of Medicine
Harvard Medical School and
Massachusetts General Hospital Cancer Center
Building 149, 13th Street , Room 7-213
Charlestown, MA 02129, USA
Office Phone: 617-643-4374
jwhetstine@hms.harvard.edu

= INDIANAPOLIS, Indiana University-Purdue University, Indianapolis. Postdoctoral position in DNA repair and genomic stability. =

'A postdoctoral position is available for qualified graduates to pursue further training in genetics/molecular biology. We use molecular and classic genetics approaches to examine the mechanisms of DNA repair and recombination in yeast Saccharomyces cerevisiae – a model eukaryotic organism. The successful candidate will investigate genetic and environmental factors that channel repair of double-strand DNA breaks into dangerous repair pathways (break-induced replication, single-strand annealing, and breakage-fusion-bridge cycles) leading to genomic instabilities.

Applicants should hold a Ph.D. in Biology, Molecular Biology or a related life science discipline. The ideal applicant should have experience in genetics and molecular biology.
The laboratory is located on the campus of Indiana University Purdue University – Indianapolis. This campus is in downtown Indianapolis, the Indiana state capital and a city of over 1 million people with outstanding resources and a low cost of living. The campus is the major academic research location in the state. Postdocs at IUPUI receive competitive compensation and benefits packages. IUPUI also offers extensive career development opportunities for our postdoctoral fellows, including a Preparing Future Faculty program.
Interested persons should send curriculum vitae and the names and contact information of three references by e-mail to amalkova@iupui.edu (Dr.Anna Malkova) with "Postdoc Opening 2008" in the message title.
'''

= Seattle, Wa Fred Hutchinson Cancer Research Center =
''''''STAFF SCIENTIST/ POSTDOCTORAL RESEARCH FELLOW ''''#KSW-21860

The overarching goal of the Paulovich laboratory at the Fred Hutchinson Cancer Research Center is to characterize human phenotypic variation and translate this variation into clinically useful diagnostics. The laboratory is a highly interdisciplinary collaborative setting in which chemists, biochemists, statisticians, computer scientists, biologists, and geneticists work closely together on projects ranging from basic yeast genetics to the mammalian cell DNA damage response to mass spectrometry and biomarker discovery.

Job Description:
This is an upper-level, flexible position for an experienced yeast geneticist to lead a new Project in the laboratory. This position is funded off of a new R01 grant aimed to characterize cellular networks that buffer the phenotypic effects of defects in the DNA damage response pathway, using the yeast S. cerevisiae as a model system.

This position can be adapted to suit a variety of career goals, including:

• a new postdoctoral fellow (with graduate training in yeast genetics) interested in developing technical and leadership skills for a future academic position

• a Staff Scientist- or Postdoctoral-level applicant who would like a long-term position in the group and the opportunity to develop a research project

• a Staff Scientist- or Postdoctoral-level applicant who has chosen not to develop his/her own laboratory at this time, but would like the opportunity to lead a small research group within our laboratory and to co-author NIH grants. This is a unique opportunity for a go-getter who wants to take his/her career to the next level but does not plan to have an independent laboratory in the next 4-5 years. Highly motivated recent graduates are encouraged to apply.

Major duties:

Scientific:
• Build new yeast strains and libraries
• Perform genetic screens for mutants sensitive to DNA damage
• Characterize mutants that buffer defects in the DNA damage response
• Carry out yeast genetics and physiology experiments: kill curves, mutation rates, recombination rates, crosses, tetrad analysis, transformation, and genotyping

Managerial:
• Assume primary responsibility for day-to-day management of the project, its budget, and its milestones
• Read relevant technical literature and play a lead role in strategic planning for the project
• Assist in hiring and managing staff for the project
• Write manuscripts for publication
• Prepare progress reports for funding agencies
• Assist in / serve as PI on future grant applications
• Present work at local and national meetings
• Provide mentorship for junior members of the team

Qualifications:
A Ph.D. and extensive experience with molecular and cellular biology techniques, as well as with YEAST MOLECULAR GENETICS, including cell mating, tetrad analysis, and physiology experiments with S. cerevisiae, are required. The successful candidate must be a highly confident self-starter who is productive when working with minimal supervision, able to read the literature critically, capable of designing experiments independently, capable of contributing intellectually to the project, and must be an effective collaborator and leader of a team.

Job Type: Full time position

Compensation: Salary DOE (or based on NIH scale for postdoctoral level) + excellent benefits

OPENING DATE: June 25, 2008; description revised 7-9-08

To apply for this position, please send cover letter, curriculum vitae, and the contact information for three professional references to:

Käthe Watanabe
Human Resources Specialist
Fred Hutchinson Cancer Research Center
Human Resources, J1-105
P.O. Box 19024
Seattle, WA 98109-1024
Email: kwatanab@fhcrc.org
Fax: 206-667-4051
Web site: http://www.fhcrc.org

=University of New Mexico =

Post doctoral position available now at the University of New Mexico, Albuquerque to study differentiation of quiescent and non-quiescent cells in yeast stationary phase cultures. This position is for a beginning post doc and applicants should have a strong background in yeast genetics, genomics, or flow cytometry. For recent work see Mol. Biol. Cell 2008 19: 1271-1280; and http://biology.unm.edu/biology/maggieww/public_html/Maggieww.html.

Applicants should email their cv and names/email address of three references to Maggie Werner-Washburne, maggieww@unm.edu.

=Duke University Medical Center=

NIH-funded postdoctoral positions are available at Duke University Medical Center to study quantitative (complex) traits in “S. cerevisiae”; for example, see Nature 416:326-330 (2002) and PLoS Genetics 2(2):e13 (2006).

Applicants should have 0 to (at most) 2 years of post-doctoral experience and a strong background in at least one of three areas – yeast genetics, quantitative/population genetics and/or genomics/informatics – and a desire to expand into the other listed areas. Start dates are flexible.

See the [http://www.duke.edu/web/microlabs/mccusker/ lab website] for more information and publications. Applicants should email their curriculum vitae and the names/email addresses of three references to John McCusker.
Email: mccus001@mc.duke.edu

= Carnegie Institution for Science, Stanford, California, USA =

Highly qualified and motivated individuals are invited to send applications for
a Postdoc Position
in the Research Group of Wolf B. Frommer
on the topic

'''Regulatory circuits controlling sugar flux in yeast grown on ethanol'''

HT screen of the yeast knock out collection using FRET sensors for glucose, sucrose and maltose, follow-up analysis of hits and reconstruction of networks

Our lab has developed a wide range of FRET sensors for metabolites. These sensors have so far been used mainly in mammalian cells to study glutamate release from neurons, glucose transport across the ER membrane or tryptophan/kynurenine exchange.

We have now been able to functionally express the FRET sensors also in the cytoplasm of yeast and to establish a high throughput screening platform. Our goal is to identify novel regulatory pathways involved in the control of glucose flux in yeast. As a first step, the kinase k.o. collection has been screened for altered glucose flux and several hits have been identified and verified.

Next steps will be to verify the hits using a new microfluidic platform, to test the effect on other sugar fluxes using FRET sensors for sucrose, maltose and ribose and to place the kinases into signaling networks. The screen can be expanded to include the whole genome at a later stage. Focus points are regulatory effects on glucose transporters and hexokinases. Due to the advanced stage, it is expected that the work will lead to high profile publications within less than a year.

Start date asap

Send your application with CV and the names of three references to:

Wolf B. Frommer
Carnegie Institution for Science
260 Panama St, Stanford CA 94305 USA.
Website[http://carnegiedpb.stanford.edu]
E-mail: wfrommer@stanford.edu

= B.A./B.S. Yeast Biochemist at Gevo, Inc., Englewood, CO, USA=

Gevo, Inc. is a high energy, team-oriented company that is pioneering the advanced green energy industry. We are looking for a term (up to one year) Biocatalyst Development Biochemist, based in Englewood, Colorado. This role is responsible for execution of analysis of metabolites on yeast biocatalysts under the direction of a senior scientist. This person will characterize yeast biocatalysts for their intra- and extracellular metabolite production, genotypes, and phenotypes. This position is considered a term position for up to one year.

Requirements include:
Bachelor degree in Biochemistry, Chemistry, Biotechnology, Microbiology or related field and 1 – 3 years of professional work experience in a lab, working with biochemical techniques and yeast. A detailed job description can be found at [http://www.gevo.com/careers.php#BDT]

Positions in yeast labs

2009-08-06T16:17:40Z

Marek: /* Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge */

= Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge=

Postdoctoral Research Associate in the group of Dr Janneke Balk, Department of Plant Sciences, University of Cambridge

Salary: £27,183-£35,469 pa Limit of tenure: grant funding is available for 3 years in the first instance. Start date: 1 January 2010

Applicants must have a PhD, and a background in fungal genetics will be highly preferred. Previous experience in molecular biology and biochemistry methods is essential. This project is funded by the Wellcome Trust and includes part-time technical assistance.

The assembly of iron-sulphur cofactors in respiratory complex I

Complex I deficiencies are the most common cause of respiratory chain dysfunction, but how this largest of the respiratory complexes is assembled, including its unique chain of eight iron-sulphur (Fe-S) clusters, is poorly understood. This project aims to investigate the assembly of complex I using the yeast Yarrowia lipolytica as a genetic model organism, and will focus on: 1) Further analysis of the molecular role of Ind1, a recently identified Fe-S scaffold protein important for complex I assembly in Yarrowia and human cell lines (Bych et al 2008; Sheftel et al, unpublished). 2) Development of Yarrowia yeast as a genetic model organism to perform forward genetics screens, complemented by a biochemical approach, to identify additional complex I assembly factors, in particular those that assist Ind1 with Fe-S cluster insertion. 3) Translation of the findings to human disease: identification of human orthologues and whether they are implicated in complex I disorders.

This project involves collaborations with Dr Judy Hirst at the MRC Cambridge (in vitro cluster assembly in complex I subunits), Professor Ulrich Brandt, Frankfurt (complex I function and genetics in Yarrowia yeast) and Professor Jan Smeitink, Nijmegen (translation of the findings to human respiratory disease).

Dr Janneke Balk started an independent research group in 2005, focussing on Fe-S protein biogenesis in (higher) eukaryotes. Her dynamic and international group is rapidly expanding and moving to new laboratory space this autumn.

The University of Cambridge is a world-class research institute, which is particulary strong in biomedical sciences.

Reference: Bych K, Kerscher S, Netz DJA, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U and Balk, J (2008). The iron-sulfur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736-46.

For further enqueries: Janneke Balk, jb511@cam.ac.uk To apply, see http://www.plantsci.cam.ac.uk/jobs/content.html

=Postdoctoral Position at University of Texas Health Science Center at San Antonio=

A postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine morphology and virulence of ''Candida albicans'', the major fungal pathogen, in response to host environmental cues (for additional details see Carlisle, et al., PNAS 106:599-604 (2009)[http://www.pnas.org/content/106/2/599.long], Banerjee et al., MBC 19:1354-1365 (2008)[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18216277] and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis.

Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis, as well as ''S. cerevisiae'' researchers interested in transitioning to fungal pathogenesis, are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu).

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

=Postdoctoral or Staff Scientist Position at Purdue University=

Postdoctoral/Staff scientist position available in yeast functional genomics of chromosome segregation at Purdue University. Project goals are to define, on a global scale, the effect of phosphorylation by the Aurora kinase on protein interactions controlling chromosome segregation process in yeast. Project is funded for up to five years by NIH and will involve high-throughput screening and lab automation, genome-wide studies, microscopy, yeast molecular biology and bioinformatic analysis. Applicants should have a recent PhD in any field of biology that includes a strong conceptual and experimental background in Genetics, and/or Molecular and Cell Biology.

Applicants should send a CV by email to Dr. Tony Hazbun listed at the following web site:
http://www.mcmp.purdue.edu/faculty/?uid=hazbun

=Postdoctoral Position at Rutgers University=

A postdoctoral position is available at the Biotech Center at Rutgers University in the laboratory of Dr. Nilgun E. Tumer to investigate the mechanisms of uptake, transport and cytotoxicity of ricin and Shiga-like toxins. The Tumer lab works on elucidating the basic mechanisms of action of ricin and Shiga-like toxins using Saccharomyces cerevisae and C. elegans as model systems. Both toxins depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. Our goal is to identify the targets of these toxins to understand the mechanism by which they kill cells and to develop therapeutic intervention strategies. The successful candidate will use genetic, cell biology and chemical genomic approaches to investigate the mechanism of uptake and transport of the toxins in yeast and C. elegans and use chemical genomics approaches to identify the cellular pathways affected by these toxins. The ideal candidate should have a Ph.D. in a related field, experience with yeast and/or C.elegans genetics and cell biology and familiarity with chemical biology approaches. The Biotech Center is located in New Brunswick, New Jersey near New York City and Philadelphia and is equipped with state-of-the-art facilities and instrumentation. Rutgers University is an equal opportunity employer that strongly encourages underrepresented groups to apply for open positions.

Interested applicants should send their CV and names and addresses of three references to Dr. Nilgun E. Tumer (tumer@aesop.rutgers.edu). Information on our research can be found at: http://biotech.rutgers.edu/faculty/tumer.html, http://aesop.rutgers.edu/~plantbiopath/faculty/tumer/TUMER.HTML, http://lifesci.rutgers.edu/~molbiosci/faculty/tumer.html
Contact: Nilgun Tumer, Foran Hall, Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520. Tel: 732-932-8165 X215.

=Postdoctoral Position, Chemical Genomics=

Research Department: Molecular Ligand Target Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute
Dr. Charles Boone, Visiting Scientist
Dr. Minoru Yoshida, Team Leader

Location: RIKEN Advanced Science Institute, RIKEN Wako Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan

Area of Research: Chemical genetics and chemical genomics

Job Description: A postdoctoral researcher position is open in the field of chemical genomics. We have constructed a unique chemical library based on natural products in the Department of Chemical Biology, RIKAN Advanced Science Institute. The successful candidate will carry out original research on global analysis of drug-target interaction using the chemical library and various yeast mutants or transformants.

Selection Process: Candidates will be selected based on research results, publications, letters of recommendation (preferably in English), etc. The CV (preferably detailed and complete) and publications must be in English.

Application Deadline: Applications are now being accepted. Position will be closed after a suitable candidate is found.

Start of Employment: Immediately

Contract Conditions: Full-time employment with the contract shall be for one year, renewable annually upon evaluation until the end of the project (March 2012). Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Moving expenses to RIKEN will be reimbursed. Social insurance will also be applicable. Days off include public holidays, New Year's holidays (Dec. 29-Jan 3), summer holidays and RIKEN Foundation Day. These and other employment provisions are in accordance with RIKEN regulations.

Information at Web: Information on our team can be found on our website (http://www.riken.go.jp/engn/r-world/research/lab/asi/chemical/index.html)

Applications: Electronic copies of your curriculum vitae/résumé, a list of publications, two or three representative publications, and two reference letters should be sent to the address below or via e-mail to "charlie.boone" (add @utoronto.ca" to complete the address):
Charles Boone
Professor, University of Toronto, Donnelly CCBR
160 College St, Rm 1306
Toronto, ON
M5S 3E1

Notes: The documents you submit will be handled with the utmost care in accordance with RIKEN's rules for the protection of personal data and will be used only for employment screening purposes. This information will not be divulged, assigned, or loaned to a third party without legitimate reason.

=Postdoctoral Position: Engineering sea lamprey antibodies=

A vacant postdoctoral position at the Center of Marine Biotechnology in Baltimore to characterize antigen binding properties of VLR, the unique variable lymphocyte receptors of sea lamprey. The successful candidate will join a study with the goal to explore biotechnology applications for these novel antibodies (Pancer & Mariuzza, Nat. Biotechnol., 2008; Rogozin et al., Nat. Immunol., 2007; Alder et al., Science 2005; Pancer et al., Nature 2004). Our research platform includes yeast displayed recombinant VLR libraries that are screened with various antigens. Biochemical and structural properties of monoclonal VLRs are then characterized.

Candidates must have a PhD with solid background in protein biochemistry and molecular biology, experience in recombinant protein expression and characterization, and relevant peer-reviewed publications.

To apply for position #300957 please submit a letter describing your research interests and experience, an updated curriculum vitae and names of three references via http://www.cytiva.com/umbi/ext/detail.asp?jobid=umbi300957

Contact: Zeev Pancer, PhD
Center of Marine Biotechnology, UMBI
Columbus Center, Suite 236
701 East Pratt St. Baltimore, MD 21202, USA
Office: 410-234-8834; Fax: 410-234-8896
Email: pancer@comb.umbi.umd.edu

=Epigenetic Postdoctoral Fellow Posting=

'''Postdoctoral positions''' are available at Massachusetts General Hospital Cancer Center. My laboratory is focused on understanding the impact that both methylation and acetylation dynamics has in both human cell culture and C. elegans. In particular, the laboratory is investigating the impact that the histone 3 lysine 9/36 tri-demethylases [JMJD2A-D; Whetstine et al., (2007) Cell 125: 467-81] have on tumorigenesis, transcriptional regulation, and genomic integrity. The laboratory will interrogate the role of these enzymes by using genomic, proteomic, cytological and genetic approaches. Similar approaches allowed an important link to be established for histone deacetylase 1 (HDAC-1) and the regulation of extra-cellular matrix biology in both human and C. elegans, which has direct implications in cancer chemotherapy [Whetstine et al., (2005) Mol. Cell 18:483-90]. The laboratory will continue to investigate the functional overlap or unique pathways that the C. elegans class I histone deacetylases regulate by using the same type of approaches. Overall, the laboratory will integrate a number of approaches and systems to determine the important biological pathways regulated by histone demethylases and histone deacetylases.

The laboratory is looking for highly motivated, tenacious scientists that are enthusiastic, team players and love science. The laboratory is looking for researchers with documented proficiency in any of the following areas (basic molecular biology, protein biochemistry, genomics, epigenetics, C. elegans, cytology, development biology, DNA damage and repair) but interested in learning new approaches or systems to answer the exciting questions before us.

Requirements:
For these positions a Ph.D. and/or M.D. is required. These positions require enthusiastic, self motivated, independent thinkers with strong interpersonal skills, and the ability to communicate with laboratory members, national and international collaborators. Please have three letters of recommendation sent to the below address and/or e-mail.

Johnathan R. Whetstine, Ph.D.
Assistant Professor of Medicine
Harvard Medical School and
Massachusetts General Hospital Cancer Center
Building 149, 13th Street , Room 7-213
Charlestown, MA 02129, USA
Office Phone: 617-643-4374
jwhetstine@hms.harvard.edu

= INDIANAPOLIS, Indiana University-Purdue University, Indianapolis. Postdoctoral position in DNA repair and genomic stability. =

'A postdoctoral position is available for qualified graduates to pursue further training in genetics/molecular biology. We use molecular and classic genetics approaches to examine the mechanisms of DNA repair and recombination in yeast Saccharomyces cerevisiae – a model eukaryotic organism. The successful candidate will investigate genetic and environmental factors that channel repair of double-strand DNA breaks into dangerous repair pathways (break-induced replication, single-strand annealing, and breakage-fusion-bridge cycles) leading to genomic instabilities.

Applicants should hold a Ph.D. in Biology, Molecular Biology or a related life science discipline. The ideal applicant should have experience in genetics and molecular biology.
The laboratory is located on the campus of Indiana University Purdue University – Indianapolis. This campus is in downtown Indianapolis, the Indiana state capital and a city of over 1 million people with outstanding resources and a low cost of living. The campus is the major academic research location in the state. Postdocs at IUPUI receive competitive compensation and benefits packages. IUPUI also offers extensive career development opportunities for our postdoctoral fellows, including a Preparing Future Faculty program.
Interested persons should send curriculum vitae and the names and contact information of three references by e-mail to amalkova@iupui.edu (Dr.Anna Malkova) with "Postdoc Opening 2008" in the message title.
'''

= Seattle, Wa Fred Hutchinson Cancer Research Center =
''''''STAFF SCIENTIST/ POSTDOCTORAL RESEARCH FELLOW ''''#KSW-21860

The overarching goal of the Paulovich laboratory at the Fred Hutchinson Cancer Research Center is to characterize human phenotypic variation and translate this variation into clinically useful diagnostics. The laboratory is a highly interdisciplinary collaborative setting in which chemists, biochemists, statisticians, computer scientists, biologists, and geneticists work closely together on projects ranging from basic yeast genetics to the mammalian cell DNA damage response to mass spectrometry and biomarker discovery.

Job Description:
This is an upper-level, flexible position for an experienced yeast geneticist to lead a new Project in the laboratory. This position is funded off of a new R01 grant aimed to characterize cellular networks that buffer the phenotypic effects of defects in the DNA damage response pathway, using the yeast S. cerevisiae as a model system.

This position can be adapted to suit a variety of career goals, including:

• a new postdoctoral fellow (with graduate training in yeast genetics) interested in developing technical and leadership skills for a future academic position

• a Staff Scientist- or Postdoctoral-level applicant who would like a long-term position in the group and the opportunity to develop a research project

• a Staff Scientist- or Postdoctoral-level applicant who has chosen not to develop his/her own laboratory at this time, but would like the opportunity to lead a small research group within our laboratory and to co-author NIH grants. This is a unique opportunity for a go-getter who wants to take his/her career to the next level but does not plan to have an independent laboratory in the next 4-5 years. Highly motivated recent graduates are encouraged to apply.

Major duties:

Scientific:
• Build new yeast strains and libraries
• Perform genetic screens for mutants sensitive to DNA damage
• Characterize mutants that buffer defects in the DNA damage response
• Carry out yeast genetics and physiology experiments: kill curves, mutation rates, recombination rates, crosses, tetrad analysis, transformation, and genotyping

Managerial:
• Assume primary responsibility for day-to-day management of the project, its budget, and its milestones
• Read relevant technical literature and play a lead role in strategic planning for the project
• Assist in hiring and managing staff for the project
• Write manuscripts for publication
• Prepare progress reports for funding agencies
• Assist in / serve as PI on future grant applications
• Present work at local and national meetings
• Provide mentorship for junior members of the team

Qualifications:
A Ph.D. and extensive experience with molecular and cellular biology techniques, as well as with YEAST MOLECULAR GENETICS, including cell mating, tetrad analysis, and physiology experiments with S. cerevisiae, are required. The successful candidate must be a highly confident self-starter who is productive when working with minimal supervision, able to read the literature critically, capable of designing experiments independently, capable of contributing intellectually to the project, and must be an effective collaborator and leader of a team.

Job Type: Full time position

Compensation: Salary DOE (or based on NIH scale for postdoctoral level) + excellent benefits

OPENING DATE: June 25, 2008; description revised 7-9-08

To apply for this position, please send cover letter, curriculum vitae, and the contact information for three professional references to:

Käthe Watanabe
Human Resources Specialist
Fred Hutchinson Cancer Research Center
Human Resources, J1-105
P.O. Box 19024
Seattle, WA 98109-1024
Email: kwatanab@fhcrc.org
Fax: 206-667-4051
Web site: http://www.fhcrc.org

=University of New Mexico =

Post doctoral position available now at the University of New Mexico, Albuquerque to study differentiation of quiescent and non-quiescent cells in yeast stationary phase cultures. This position is for a beginning post doc and applicants should have a strong background in yeast genetics, genomics, or flow cytometry. For recent work see Mol. Biol. Cell 2008 19: 1271-1280; and http://biology.unm.edu/biology/maggieww/public_html/Maggieww.html.

Applicants should email their cv and names/email address of three references to Maggie Werner-Washburne, maggieww@unm.edu.

=Duke University Medical Center=

NIH-funded postdoctoral positions are available at Duke University Medical Center to study quantitative (complex) traits in “S. cerevisiae”; for example, see Nature 416:326-330 (2002) and PLoS Genetics 2(2):e13 (2006).

Applicants should have 0 to (at most) 2 years of post-doctoral experience and a strong background in at least one of three areas – yeast genetics, quantitative/population genetics and/or genomics/informatics – and a desire to expand into the other listed areas. Start dates are flexible.

See the [http://www.duke.edu/web/microlabs/mccusker/ lab website] for more information and publications. Applicants should email their curriculum vitae and the names/email addresses of three references to John McCusker.
Email: mccus001@mc.duke.edu

= Carnegie Institution for Science, Stanford, California, USA =

Highly qualified and motivated individuals are invited to send applications for
a Postdoc Position
in the Research Group of Wolf B. Frommer
on the topic

'''Regulatory circuits controlling sugar flux in yeast grown on ethanol'''

HT screen of the yeast knock out collection using FRET sensors for glucose, sucrose and maltose, follow-up analysis of hits and reconstruction of networks

Our lab has developed a wide range of FRET sensors for metabolites. These sensors have so far been used mainly in mammalian cells to study glutamate release from neurons, glucose transport across the ER membrane or tryptophan/kynurenine exchange.

We have now been able to functionally express the FRET sensors also in the cytoplasm of yeast and to establish a high throughput screening platform. Our goal is to identify novel regulatory pathways involved in the control of glucose flux in yeast. As a first step, the kinase k.o. collection has been screened for altered glucose flux and several hits have been identified and verified.

Next steps will be to verify the hits using a new microfluidic platform, to test the effect on other sugar fluxes using FRET sensors for sucrose, maltose and ribose and to place the kinases into signaling networks. The screen can be expanded to include the whole genome at a later stage. Focus points are regulatory effects on glucose transporters and hexokinases. Due to the advanced stage, it is expected that the work will lead to high profile publications within less than a year.

Start date asap

Send your application with CV and the names of three references to:

Wolf B. Frommer
Carnegie Institution for Science
260 Panama St, Stanford CA 94305 USA.
Website[http://carnegiedpb.stanford.edu]
E-mail: wfrommer@stanford.edu

= B.A./B.S. Yeast Biochemist at Gevo, Inc., Englewood, CO, USA=

Gevo, Inc. is a high energy, team-oriented company that is pioneering the advanced green energy industry. We are looking for a term (up to one year) Biocatalyst Development Biochemist, based in Englewood, Colorado. This role is responsible for execution of analysis of metabolites on yeast biocatalysts under the direction of a senior scientist. This person will characterize yeast biocatalysts for their intra- and extracellular metabolite production, genotypes, and phenotypes. This position is considered a term position for up to one year.

Requirements include:
Bachelor degree in Biochemistry, Chemistry, Biotechnology, Microbiology or related field and 1 – 3 years of professional work experience in a lab, working with biochemical techniques and yeast. A detailed job description can be found at [http://www.gevo.com/careers.php#BDT]

Positions in yeast labs

2009-08-06T14:27:54Z

Marek:

= Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge=

Postdoctoral Research Associate in the group of Dr Janneke Balk, Department of Plant Sciences, University of Cambridge

Salary: £27,183-£35,469 pa Limit of tenure: grant funding is available for 3 years in the first instance. Start date: 1 January 2010

Applicants must have a PhD, and a background in fungal genetics will be highly preferred. Previous experience in molecular biology and biochemistry methods is essential. This project is funded by the Wellcome Trust and includes part-time technical assistance.

The assembly of iron-sulphur cofactors in respiratory complex I Complex I deficiencies are the most common cause of respiratory chain dysfunction, but how this largest of the respiratory complexes is assembled, including its unique chain of eight iron-sulphur (Fe-S) clusters, is poorly understood. This project aims to investigate the assembly of complex I using the yeast Yarrowia lipolytica as a genetic model organism, and will focus on: 1) Further analysis of the molecular role of Ind1, a recently identified Fe-S scaffold protein important for complex I assembly in Yarrowia and human cell lines (Bych et al 2008; Sheftel et al, unpublished). 2) Development of Yarrowia yeast as a genetic model organism to perform forward genetics screens, complemented by a biochemical approach, to identify additional complex I assembly factors, in particular those that assist Ind1 with Fe-S cluster insertion. 3) Translation of the findings to human disease: identification of human orthologues and whether they are implicated in complex I disorders.

This project involves collaborations with Dr Judy Hirst at the MRC Cambridge (in vitro cluster assembly in complex I subunits), Professor Ulrich Brandt, Frankfurt (complex I function and genetics in Yarrowia yeast) and Professor Jan Smeitink, Nijmegen (translation of the findings to human respiratory disease). Dr Janneke Balk started an independent research group in 2005, focussing on Fe-S protein biogenesis in (higher) eukaryotes. Her dynamic and international group is rapidly expanding and moving to new laboratory space this autumn.

The University of Cambridge is a world-class research institute, which is particulary strong in biomedical sciences. Reference: Bych K, Kerscher S, Netz DJA, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U and Balk, J (2008). The iron-sulfur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736-46.

For further enqueries: Janneke Balk, jb511@cam.ac.uk To apply, see http://www.plantsci.cam.ac.uk/jobs/content.html

=Postdoctoral Position at University of Texas Health Science Center at San Antonio=

A postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine morphology and virulence of ''Candida albicans'', the major fungal pathogen, in response to host environmental cues (for additional details see Carlisle, et al., PNAS 106:599-604 (2009)[http://www.pnas.org/content/106/2/599.long], Banerjee et al., MBC 19:1354-1365 (2008)[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18216277] and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis.

Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis, as well as ''S. cerevisiae'' researchers interested in transitioning to fungal pathogenesis, are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu).

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

=Postdoctoral or Staff Scientist Position at Purdue University=

Postdoctoral/Staff scientist position available in yeast functional genomics of chromosome segregation at Purdue University. Project goals are to define, on a global scale, the effect of phosphorylation by the Aurora kinase on protein interactions controlling chromosome segregation process in yeast. Project is funded for up to five years by NIH and will involve high-throughput screening and lab automation, genome-wide studies, microscopy, yeast molecular biology and bioinformatic analysis. Applicants should have a recent PhD in any field of biology that includes a strong conceptual and experimental background in Genetics, and/or Molecular and Cell Biology.

Applicants should send a CV by email to Dr. Tony Hazbun listed at the following web site:
http://www.mcmp.purdue.edu/faculty/?uid=hazbun

=Postdoctoral Position at Rutgers University=

A postdoctoral position is available at the Biotech Center at Rutgers University in the laboratory of Dr. Nilgun E. Tumer to investigate the mechanisms of uptake, transport and cytotoxicity of ricin and Shiga-like toxins. The Tumer lab works on elucidating the basic mechanisms of action of ricin and Shiga-like toxins using Saccharomyces cerevisae and C. elegans as model systems. Both toxins depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. Our goal is to identify the targets of these toxins to understand the mechanism by which they kill cells and to develop therapeutic intervention strategies. The successful candidate will use genetic, cell biology and chemical genomic approaches to investigate the mechanism of uptake and transport of the toxins in yeast and C. elegans and use chemical genomics approaches to identify the cellular pathways affected by these toxins. The ideal candidate should have a Ph.D. in a related field, experience with yeast and/or C.elegans genetics and cell biology and familiarity with chemical biology approaches. The Biotech Center is located in New Brunswick, New Jersey near New York City and Philadelphia and is equipped with state-of-the-art facilities and instrumentation. Rutgers University is an equal opportunity employer that strongly encourages underrepresented groups to apply for open positions.

Interested applicants should send their CV and names and addresses of three references to Dr. Nilgun E. Tumer (tumer@aesop.rutgers.edu). Information on our research can be found at: http://biotech.rutgers.edu/faculty/tumer.html, http://aesop.rutgers.edu/~plantbiopath/faculty/tumer/TUMER.HTML, http://lifesci.rutgers.edu/~molbiosci/faculty/tumer.html
Contact: Nilgun Tumer, Foran Hall, Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520. Tel: 732-932-8165 X215.

=Postdoctoral Position, Chemical Genomics=

Research Department: Molecular Ligand Target Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute
Dr. Charles Boone, Visiting Scientist
Dr. Minoru Yoshida, Team Leader

Location: RIKEN Advanced Science Institute, RIKEN Wako Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan

Area of Research: Chemical genetics and chemical genomics

Job Description: A postdoctoral researcher position is open in the field of chemical genomics. We have constructed a unique chemical library based on natural products in the Department of Chemical Biology, RIKAN Advanced Science Institute. The successful candidate will carry out original research on global analysis of drug-target interaction using the chemical library and various yeast mutants or transformants.

Selection Process: Candidates will be selected based on research results, publications, letters of recommendation (preferably in English), etc. The CV (preferably detailed and complete) and publications must be in English.

Application Deadline: Applications are now being accepted. Position will be closed after a suitable candidate is found.

Start of Employment: Immediately

Contract Conditions: Full-time employment with the contract shall be for one year, renewable annually upon evaluation until the end of the project (March 2012). Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Moving expenses to RIKEN will be reimbursed. Social insurance will also be applicable. Days off include public holidays, New Year's holidays (Dec. 29-Jan 3), summer holidays and RIKEN Foundation Day. These and other employment provisions are in accordance with RIKEN regulations.

Information at Web: Information on our team can be found on our website (http://www.riken.go.jp/engn/r-world/research/lab/asi/chemical/index.html)

Applications: Electronic copies of your curriculum vitae/résumé, a list of publications, two or three representative publications, and two reference letters should be sent to the address below or via e-mail to "charlie.boone" (add @utoronto.ca" to complete the address):
Charles Boone
Professor, University of Toronto, Donnelly CCBR
160 College St, Rm 1306
Toronto, ON
M5S 3E1

Notes: The documents you submit will be handled with the utmost care in accordance with RIKEN's rules for the protection of personal data and will be used only for employment screening purposes. This information will not be divulged, assigned, or loaned to a third party without legitimate reason.

=Postdoctoral Position: Engineering sea lamprey antibodies=

A vacant postdoctoral position at the Center of Marine Biotechnology in Baltimore to characterize antigen binding properties of VLR, the unique variable lymphocyte receptors of sea lamprey. The successful candidate will join a study with the goal to explore biotechnology applications for these novel antibodies (Pancer & Mariuzza, Nat. Biotechnol., 2008; Rogozin et al., Nat. Immunol., 2007; Alder et al., Science 2005; Pancer et al., Nature 2004). Our research platform includes yeast displayed recombinant VLR libraries that are screened with various antigens. Biochemical and structural properties of monoclonal VLRs are then characterized.

Candidates must have a PhD with solid background in protein biochemistry and molecular biology, experience in recombinant protein expression and characterization, and relevant peer-reviewed publications.

To apply for position #300957 please submit a letter describing your research interests and experience, an updated curriculum vitae and names of three references via http://www.cytiva.com/umbi/ext/detail.asp?jobid=umbi300957

Contact: Zeev Pancer, PhD
Center of Marine Biotechnology, UMBI
Columbus Center, Suite 236
701 East Pratt St. Baltimore, MD 21202, USA
Office: 410-234-8834; Fax: 410-234-8896
Email: pancer@comb.umbi.umd.edu

=Epigenetic Postdoctoral Fellow Posting=

'''Postdoctoral positions''' are available at Massachusetts General Hospital Cancer Center. My laboratory is focused on understanding the impact that both methylation and acetylation dynamics has in both human cell culture and C. elegans. In particular, the laboratory is investigating the impact that the histone 3 lysine 9/36 tri-demethylases [JMJD2A-D; Whetstine et al., (2007) Cell 125: 467-81] have on tumorigenesis, transcriptional regulation, and genomic integrity. The laboratory will interrogate the role of these enzymes by using genomic, proteomic, cytological and genetic approaches. Similar approaches allowed an important link to be established for histone deacetylase 1 (HDAC-1) and the regulation of extra-cellular matrix biology in both human and C. elegans, which has direct implications in cancer chemotherapy [Whetstine et al., (2005) Mol. Cell 18:483-90]. The laboratory will continue to investigate the functional overlap or unique pathways that the C. elegans class I histone deacetylases regulate by using the same type of approaches. Overall, the laboratory will integrate a number of approaches and systems to determine the important biological pathways regulated by histone demethylases and histone deacetylases.

The laboratory is looking for highly motivated, tenacious scientists that are enthusiastic, team players and love science. The laboratory is looking for researchers with documented proficiency in any of the following areas (basic molecular biology, protein biochemistry, genomics, epigenetics, C. elegans, cytology, development biology, DNA damage and repair) but interested in learning new approaches or systems to answer the exciting questions before us.

Requirements:
For these positions a Ph.D. and/or M.D. is required. These positions require enthusiastic, self motivated, independent thinkers with strong interpersonal skills, and the ability to communicate with laboratory members, national and international collaborators. Please have three letters of recommendation sent to the below address and/or e-mail.

Johnathan R. Whetstine, Ph.D.
Assistant Professor of Medicine
Harvard Medical School and
Massachusetts General Hospital Cancer Center
Building 149, 13th Street , Room 7-213
Charlestown, MA 02129, USA
Office Phone: 617-643-4374
jwhetstine@hms.harvard.edu

= INDIANAPOLIS, Indiana University-Purdue University, Indianapolis. Postdoctoral position in DNA repair and genomic stability. =

'A postdoctoral position is available for qualified graduates to pursue further training in genetics/molecular biology. We use molecular and classic genetics approaches to examine the mechanisms of DNA repair and recombination in yeast Saccharomyces cerevisiae – a model eukaryotic organism. The successful candidate will investigate genetic and environmental factors that channel repair of double-strand DNA breaks into dangerous repair pathways (break-induced replication, single-strand annealing, and breakage-fusion-bridge cycles) leading to genomic instabilities.

Applicants should hold a Ph.D. in Biology, Molecular Biology or a related life science discipline. The ideal applicant should have experience in genetics and molecular biology.
The laboratory is located on the campus of Indiana University Purdue University – Indianapolis. This campus is in downtown Indianapolis, the Indiana state capital and a city of over 1 million people with outstanding resources and a low cost of living. The campus is the major academic research location in the state. Postdocs at IUPUI receive competitive compensation and benefits packages. IUPUI also offers extensive career development opportunities for our postdoctoral fellows, including a Preparing Future Faculty program.
Interested persons should send curriculum vitae and the names and contact information of three references by e-mail to amalkova@iupui.edu (Dr.Anna Malkova) with "Postdoc Opening 2008" in the message title.
'''

= Seattle, Wa Fred Hutchinson Cancer Research Center =
''''''STAFF SCIENTIST/ POSTDOCTORAL RESEARCH FELLOW ''''#KSW-21860

The overarching goal of the Paulovich laboratory at the Fred Hutchinson Cancer Research Center is to characterize human phenotypic variation and translate this variation into clinically useful diagnostics. The laboratory is a highly interdisciplinary collaborative setting in which chemists, biochemists, statisticians, computer scientists, biologists, and geneticists work closely together on projects ranging from basic yeast genetics to the mammalian cell DNA damage response to mass spectrometry and biomarker discovery.

Job Description:
This is an upper-level, flexible position for an experienced yeast geneticist to lead a new Project in the laboratory. This position is funded off of a new R01 grant aimed to characterize cellular networks that buffer the phenotypic effects of defects in the DNA damage response pathway, using the yeast S. cerevisiae as a model system.

This position can be adapted to suit a variety of career goals, including:

• a new postdoctoral fellow (with graduate training in yeast genetics) interested in developing technical and leadership skills for a future academic position

• a Staff Scientist- or Postdoctoral-level applicant who would like a long-term position in the group and the opportunity to develop a research project

• a Staff Scientist- or Postdoctoral-level applicant who has chosen not to develop his/her own laboratory at this time, but would like the opportunity to lead a small research group within our laboratory and to co-author NIH grants. This is a unique opportunity for a go-getter who wants to take his/her career to the next level but does not plan to have an independent laboratory in the next 4-5 years. Highly motivated recent graduates are encouraged to apply.

Major duties:

Scientific:
• Build new yeast strains and libraries
• Perform genetic screens for mutants sensitive to DNA damage
• Characterize mutants that buffer defects in the DNA damage response
• Carry out yeast genetics and physiology experiments: kill curves, mutation rates, recombination rates, crosses, tetrad analysis, transformation, and genotyping

Managerial:
• Assume primary responsibility for day-to-day management of the project, its budget, and its milestones
• Read relevant technical literature and play a lead role in strategic planning for the project
• Assist in hiring and managing staff for the project
• Write manuscripts for publication
• Prepare progress reports for funding agencies
• Assist in / serve as PI on future grant applications
• Present work at local and national meetings
• Provide mentorship for junior members of the team

Qualifications:
A Ph.D. and extensive experience with molecular and cellular biology techniques, as well as with YEAST MOLECULAR GENETICS, including cell mating, tetrad analysis, and physiology experiments with S. cerevisiae, are required. The successful candidate must be a highly confident self-starter who is productive when working with minimal supervision, able to read the literature critically, capable of designing experiments independently, capable of contributing intellectually to the project, and must be an effective collaborator and leader of a team.

Job Type: Full time position

Compensation: Salary DOE (or based on NIH scale for postdoctoral level) + excellent benefits

OPENING DATE: June 25, 2008; description revised 7-9-08

To apply for this position, please send cover letter, curriculum vitae, and the contact information for three professional references to:

Käthe Watanabe
Human Resources Specialist
Fred Hutchinson Cancer Research Center
Human Resources, J1-105
P.O. Box 19024
Seattle, WA 98109-1024
Email: kwatanab@fhcrc.org
Fax: 206-667-4051
Web site: http://www.fhcrc.org

=University of New Mexico =

Post doctoral position available now at the University of New Mexico, Albuquerque to study differentiation of quiescent and non-quiescent cells in yeast stationary phase cultures. This position is for a beginning post doc and applicants should have a strong background in yeast genetics, genomics, or flow cytometry. For recent work see Mol. Biol. Cell 2008 19: 1271-1280; and http://biology.unm.edu/biology/maggieww/public_html/Maggieww.html.

Applicants should email their cv and names/email address of three references to Maggie Werner-Washburne, maggieww@unm.edu.

=Duke University Medical Center=

NIH-funded postdoctoral positions are available at Duke University Medical Center to study quantitative (complex) traits in “S. cerevisiae”; for example, see Nature 416:326-330 (2002) and PLoS Genetics 2(2):e13 (2006).

Applicants should have 0 to (at most) 2 years of post-doctoral experience and a strong background in at least one of three areas – yeast genetics, quantitative/population genetics and/or genomics/informatics – and a desire to expand into the other listed areas. Start dates are flexible.

See the [http://www.duke.edu/web/microlabs/mccusker/ lab website] for more information and publications. Applicants should email their curriculum vitae and the names/email addresses of three references to John McCusker.
Email: mccus001@mc.duke.edu

= Carnegie Institution for Science, Stanford, California, USA =

Highly qualified and motivated individuals are invited to send applications for
a Postdoc Position
in the Research Group of Wolf B. Frommer
on the topic

'''Regulatory circuits controlling sugar flux in yeast grown on ethanol'''

HT screen of the yeast knock out collection using FRET sensors for glucose, sucrose and maltose, follow-up analysis of hits and reconstruction of networks

Our lab has developed a wide range of FRET sensors for metabolites. These sensors have so far been used mainly in mammalian cells to study glutamate release from neurons, glucose transport across the ER membrane or tryptophan/kynurenine exchange.

We have now been able to functionally express the FRET sensors also in the cytoplasm of yeast and to establish a high throughput screening platform. Our goal is to identify novel regulatory pathways involved in the control of glucose flux in yeast. As a first step, the kinase k.o. collection has been screened for altered glucose flux and several hits have been identified and verified.

Next steps will be to verify the hits using a new microfluidic platform, to test the effect on other sugar fluxes using FRET sensors for sucrose, maltose and ribose and to place the kinases into signaling networks. The screen can be expanded to include the whole genome at a later stage. Focus points are regulatory effects on glucose transporters and hexokinases. Due to the advanced stage, it is expected that the work will lead to high profile publications within less than a year.

Start date asap

Send your application with CV and the names of three references to:

Wolf B. Frommer
Carnegie Institution for Science
260 Panama St, Stanford CA 94305 USA.
Website[http://carnegiedpb.stanford.edu]
E-mail: wfrommer@stanford.edu

= B.A./B.S. Yeast Biochemist at Gevo, Inc., Englewood, CO, USA=

Gevo, Inc. is a high energy, team-oriented company that is pioneering the advanced green energy industry. We are looking for a term (up to one year) Biocatalyst Development Biochemist, based in Englewood, Colorado. This role is responsible for execution of analysis of metabolites on yeast biocatalysts under the direction of a senior scientist. This person will characterize yeast biocatalysts for their intra- and extracellular metabolite production, genotypes, and phenotypes. This position is considered a term position for up to one year.

Requirements include:
Bachelor degree in Biochemistry, Chemistry, Biotechnology, Microbiology or related field and 1 – 3 years of professional work experience in a lab, working with biochemical techniques and yeast. A detailed job description can be found at [http://www.gevo.com/careers.php#BDT]