SGD-Wiki - User contributions [en]

YKL114C

2015-12-18T19:08:35Z

Macdiarmid:

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001597 YKL114C]
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''APN1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:224455..223352
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001597
|}
 
'''Description of YKL114C:''' Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine<ref name='S000082522'>Ishchenko AA, et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25(15):6380-90 {{SGDpaper|S000082522}} PMID 16024777</ref><ref name='S000039558'>Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 {{SGDpaper|S000039558}} PMID 1693433</ref><ref name='S000054159'>Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44
{{SGDpaper|S000054159}} PMID 1715020</ref>
 
 
 
 
 
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==Community Commentary==
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The apn1::kanmx4 homozygous diploid mutant from the BY4743 deletion mutant collection displays a growth defect unrelated to the apn1::kanmx4 marker. The haploid BY4742 apn1 deletion mutant also displays this growth defect, suggesting an unidentified semi-dominant mutation arose during construction of this strain. Reconstruction of apn1::kanmx4 in by4741 or by4742 did not recapitulate this growth defect. Literature on the apn1 mutation confirms that apn1 deletion does not normally confer a growth defect in standard (YPD, SD) medium.
Colin MacDiarmid, personal communication.




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==References==

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YKL114C

2015-12-18T19:06:06Z

Macdiarmid: /* References */

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{|{{Prettytable}} align = 'right' width = '200px'
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001597 YKL114C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''APN1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:224455..223352
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001597
|}
 
'''Description of YKL114C:''' Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine<ref name='S000082522'>Ishchenko AA, et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25(15):6380-90 {{SGDpaper|S000082522}} PMID 16024777</ref><ref name='S000039558'>Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 {{SGDpaper|S000039558}} PMID 1693433</ref><ref name='S000054159'>Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44
{{SGDpaper|S000054159}} PMID 1715020</ref>
 
 
 
 
 
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==Community Commentary==
{{CommentaryHelp}}




<protect>
==References==

{{RefHelp}}
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YKL114C

2015-12-18T19:05:48Z

Macdiarmid: /* References */

{{PageTop}}
<protect>
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001597 YKL114C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''APN1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XI:224455..223352
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001597
|}
 
'''Description of YKL114C:''' Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine<ref name='S000082522'>Ishchenko AA, et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25(15):6380-90 {{SGDpaper|S000082522}} PMID 16024777</ref><ref name='S000039558'>Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 {{SGDpaper|S000039558}} PMID 1693433</ref><ref name='S000054159'>Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44
{{SGDpaper|S000054159}} PMID 1715020</ref>
 
 
 
 
 
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==Community Commentary==
{{CommentaryHelp}}




<protect>
==References==

{{RefHelp}}
</protect>

The apn1::kanmx4 homozygous diploid mutant from the BY4743 deletion mutant collection displays a growth defect unrelated to the apn1::kanmx4 marker. The haploid BY4742 apn1 deletion mutant also displays this growth defect, suggesting an unidentified semi-dominant mutation arose during construction of this strain. Reconstruction of apn1::kanmx4 in by4741 or by4742 did not recapitulate this growth defect. Literature on the apn1 mutation confirms that apn1 deletion does not normally confer a growth defect in standard (YPD, SD) medium.
Colin MacDiarmid, personal communication.