SGD-Wiki - User contributions [en]

Positions in yeast labs

2017-10-31T16:48:17Z

JHMcCusker:

=='''Postdoc Opening - Autophagy of lipid droplets in YEAST (posted 29 August 2017)'''==

'''Postdoctoral project:''' Autophagy of lipid droplets in YEAST

::'''Academic institution:''' University of California, San Diego
::
::'''Academic division:''' Division of Biological Sciences
::
::'''Academic unit:''' Section of Molecular Biology

'''Description:''' Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (http://postdoc.ucsd.edu/appointment-guidelines/).

'''Applicant requirements:''' The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in autophagy pathway or with LDs.

'''How to apply:''' Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu

=='''Postdoc Position in Non-coding Transcription in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is seeking a postdoc commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is for 2 years with the possibility of extension. A Hallas-Møller Investigator Award to Sebastian Marquardt funds the position.
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark.

Project description
The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . We are looking for a postdoc to work on two lab focus areas within this field:

- Divergent lncRNA Transcription (1) 
- Functional Consequences of Non-Coding Transcription (2, 3) 

The position builds on unpublished data of the lab. We have identified novel factors controlling transcription of non-coding sequences in budding yeast. You will determine the genome-wide effect of these factors by suitable cutting-edge transcriptomics techniques. You will help to elucidate the molecular mechanisms that are required for divergent non-coding transcription from gene promoters. We use the knowledge of molecular mechanisms to study the functional roles of non-coding transcription in yeast and plants.

We are seeking an enthusiastic candidate familiar with high-throughput approaches, ideally with topically relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and application requirements:

http://jobportal.ku.dk/alle-opslag/?show=904563

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014
(2) Marquardt et al. Mol Cell. 2014
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors

=='''Ph.D. Fellow in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
Project description
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is offering a 3-year Ph.D.-fellowship commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is funded by a Hallas-Møller Investigator Award to Sebastian Marquardt.
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark

The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . Our preliminary data support a Ph.D. position in any of these three focus areas within non-coding transcription research:

- Divergent lncRNA Transcription (1) 
- Functional Consequences of Non-Coding Transcription (2, 3) 
- Transcription Kinetics in Environmental Interactions (4) 

Please specify in your Cover Letter what attracts you for a Ph. D. in any of these focus areas. Our lab employs cutting edge budding yeast technology to identify the molecular mechanisms controlling transcription of non-coding sequences. The knowledge of non-coding transcription mechanisms helps us to study the functional roles of non-coding transcription. For example, we disrupt non-coding transcription in Arabidopsis to identify roles of non-coding transcription in plant environmental responses. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/

A successful candidate will be enthusiastic about the general research area, ideally with relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and requirements:
http://jobportal.ku.dk/alle-opslag/?show=904540

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014
(2) Marquardt et al. Mol Cell. 2014
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors
(4) Hazelbaker, Marquardt, et al. Mol Cell. 2013

=='''12 PhD in yeast biotechnology. Europe. ==
12 PhD opportunities in YEAST Biotechnology in a European Network called YEASTDOC https://yeastdoc.eu/recruitment/ are available. This is a high quality programmes that deliver comprehensive training in many aspects of yeast biotechnology – as well as an exciting research project that includes interaction with industry partners.

Applicants from any nationality anywhere in the world are eligible to apply and the application deadline is November 13th.

Application deadline: 01/04/2017. Applications will be reviewed on an ongoing basis.

Positions in yeast labs

2017-09-20T19:26:56Z

JHMcCusker:

==Post-doc Opening - quantitative genetics of drug resistance in Saccharomyces cerevisiae==

Project Description
A post-doc position is open in the laboratory of John McCusker (https://mgm.duke.edu/faculty-and-research/primary-faculty/john-h-mccusker-phd/) in the Department of Molecular Genetics & Microbiology at Duke University Medical Center on a newly funded R01 to work on the quantitative genetics of drug resistance in Saccharomyces cerevisiae. The post-doc position requires demonstrated productivity (i.e. publications) as well as expertise in genetics (preferably microbial, ideally with S. cerevisiae) and in molecular biology. Please provide curriculum vitae, as well as the names and contact information for three references.

Applications must be made via Academic Jobs Online (https://academicjobsonline.org/ajo/jobs/9718).

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, gender expression, national origin, race, religion, sexual orientation, or veteran status.

=='''Postdoc Opening - Autophagy of lipid droplets in YEAST (posted 29 August 2017)'''==

'''Postdoctoral project:''' Autophagy of lipid droplets in YEAST

::'''Academic institution:''' University of California, San Diego
::
::'''Academic division:''' Division of Biological Sciences
::
::'''Academic unit:''' Section of Molecular Biology

'''Description:''' Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (http://postdoc.ucsd.edu/appointment-guidelines/).

'''Applicant requirements:''' The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in autophagy pathway or with LDs.

'''How to apply:''' Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu

=='''Postdoc Position in Non-coding Transcription in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is seeking a postdoc commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is for 2 years with the possibility of extension. A Hallas-Møller Investigator Award to Sebastian Marquardt funds the position.
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark.

Project description
The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . We are looking for a postdoc to work on two lab focus areas within this field:

- Divergent lncRNA Transcription (1) 
- Functional Consequences of Non-Coding Transcription (2, 3) 

The position builds on unpublished data of the lab. We have identified novel factors controlling transcription of non-coding sequences in budding yeast. You will determine the genome-wide effect of these factors by suitable cutting-edge transcriptomics techniques. You will help to elucidate the molecular mechanisms that are required for divergent non-coding transcription from gene promoters. We use the knowledge of molecular mechanisms to study the functional roles of non-coding transcription in yeast and plants.

We are seeking an enthusiastic candidate familiar with high-throughput approaches, ideally with topically relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and application requirements:

http://jobportal.ku.dk/alle-opslag/?show=904563

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014
(2) Marquardt et al. Mol Cell. 2014
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors

=='''Ph.D. Fellow in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
Project description
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is offering a 3-year Ph.D.-fellowship commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is funded by a Hallas-Møller Investigator Award to Sebastian Marquardt.
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark

The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . Our preliminary data support a Ph.D. position in any of these three focus areas within non-coding transcription research:

- Divergent lncRNA Transcription (1) 
- Functional Consequences of Non-Coding Transcription (2, 3) 
- Transcription Kinetics in Environmental Interactions (4) 

Please specify in your Cover Letter what attracts you for a Ph. D. in any of these focus areas. Our lab employs cutting edge budding yeast technology to identify the molecular mechanisms controlling transcription of non-coding sequences. The knowledge of non-coding transcription mechanisms helps us to study the functional roles of non-coding transcription. For example, we disrupt non-coding transcription in Arabidopsis to identify roles of non-coding transcription in plant environmental responses. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/

A successful candidate will be enthusiastic about the general research area, ideally with relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and requirements:
http://jobportal.ku.dk/alle-opslag/?show=904540

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014
(2) Marquardt et al. Mol Cell. 2014
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors
(4) Hazelbaker, Marquardt, et al. Mol Cell. 2013

=='''Postdoctoral position in synthetic biology. Montpellier, France. (posted january 20, 2017)''' ==

A post-doctoral position is available for 24 months at the “UMR-Sciences pour l’Œnologie de Montpellier” (UMR INRA 1083), in the Microbiology team, starting approximately in March 2017.

This work is part of a project financed by the “Agence Nationale de la Recherche” (ANR) (for details see ENZINVIVO project http://www.agence-nationale-recherche.fr/fileadmin/aap/2016/selection/aap-g-anr-DS10-selection-2016.pdf).
Enzyme reactions have long been analyzed in vitro, using pure enzymes and diluted buffer conditions. Due to the large amount of data generated and collected with thousands of enzymes, enzymology has made tremendous progress on understanding the incredible power of biocatalysts. However, dilute, in vitro conditions are far from the surroundings of natural enzymatic reactions that take place inside cells. The cellular medium is more accurately described as a heterogeneous crowded gel, dense and filled with all sorts of macromolecules and cellular lipidic organelles which may result in some partitioning effects and changes in diffusion. Therefore, enzymatic parameters determined using classical enzymology setups may not perfectly represent the real, in vivo based, rate and equilibrium constants. Although some advances have been made toward the comprehension of viscosity and crowding effects, we are still far to derive rate and equilibrium parameters from in vivo enzymatic reactions.
The project ENZINVIVO will address this issue focusing on two isoforms of phytoene synthase (carotenoid biosynthesis) as model enzymes. The enzymatic properties of these enzymes will be investigated in vitro, through a set of measurement in environments of increasing complexity and in vivo expressing the carotenoid biosynthesis pathway in S. cerevisiae and using synthetic biology tools and concepts to tune, at will, substrate and enzyme levels.
We aim at deciphering:
- how the intracellular medium influences enzymatic reactions.
- how can we build an in vivo approach to measure enzymatic parameters.
- how general models of enzymatic equations can be rewired to account for the complexity in vivo approaches. Our work will notably verify (or not) whether a Michaelis-Menten description of the kinetics remains valid in vivo.
The candidate will be first responsible for the construction of engineered strains with fine-tuned or inducible expression of CtrE (geranylgeranyl pyrophosphate synthase, GGPP synthase) to modulate intracellular concentration of GGPP, substrate of the phytoene synthase in a range consistent with its KM. Then, he/she will be in charge of analyzing the consequences of the heterologous pathway on the yeast physiology through multi-levels characterization of the recombinant strains.
Personal Qualifications
• A PhD in the fields of molecular biology, genetics or related fields
• Solid experience in metabolic engineering, omics approaches, and microbiology are highly desirable.
• Skills in yeast metabolism and experience in multi-partners collaborations will be also strongly appreciated.
• Ability to lead good oral and written communication skills, engaged and highly motivated.

Candidates please send a letter that describes your scientific interest and research experience, together with your CV, list of publications and the names of three references to Drs. Carole Camarasa (carole.camarasa@inra.fr) and Virginie Galeote (virginie.galeote@inra.fr).

Application deadline: 01/04/2017. Applications will be reviewed on an ongoing basis.

Positions in yeast labs

2017-09-20T19:25:50Z

JHMcCusker:

Positions in yeast labs

2017-09-11T17:51:03Z

JHMcCusker:

==’’’Post-doc Opening - quantitative genetics of drug resistance in Saccharomyces cerevisiae’’’==

Project Description
A post-doc position is open in the laboratory of John McCusker (https://mgm.duke.edu/faculty-and-research/primary-faculty/john-h-mccusker-phd/) in the Department of Molecular Genetics & Microbiology at Duke University Medical Center on a newly funded R01 to work on the quantitative genetics of drug resistance in Saccharomyces cerevisiae. The post-doc position requires demonstrated productivity (i.e. publications) as well as expertise in genetics (preferably microbial, ideally with S. cerevisiae) and in molecular biology. Please provide curriculum vitae, as well as the names and contact information for three references.

Must have own valid work authorization.

Applications must be made via Academic Jobs Online (https://academicjobsonline.org/ajo/jobs/9718).

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, gender expression, national origin, race, religion, sexual orientation, or veteran status.

=='''Postdoc Opening - Autophagy of lipid droplets in YEAST (posted 29 August 2017)'''==

'''Postdoctoral project:''' Autophagy of lipid droplets in YEAST

::'''Academic institution:''' University of California, San Diego
::
::'''Academic division:''' Division of Biological Sciences
::
::'''Academic unit:''' Section of Molecular Biology

'''Description:''' Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (http://postdoc.ucsd.edu/appointment-guidelines/).

'''Applicant requirements:''' The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in autophagy pathway or with LDs.

'''How to apply:''' Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu

=='''Postdoc Position in Non-coding Transcription in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is seeking a postdoc commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is for 2 years with the possibility of extension. A Hallas-Møller Investigator Award to Sebastian Marquardt funds the position.
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark.

Project description
The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . We are looking for a postdoc to work on two lab focus areas within this field:

- Divergent lncRNA Transcription (1) 
- Functional Consequences of Non-Coding Transcription (2, 3) 

The position builds on unpublished data of the lab. We have identified novel factors controlling transcription of non-coding sequences in budding yeast. You will determine the genome-wide effect of these factors by suitable cutting-edge transcriptomics techniques. You will help to elucidate the molecular mechanisms that are required for divergent non-coding transcription from gene promoters. We use the knowledge of molecular mechanisms to study the functional roles of non-coding transcription in yeast and plants.

We are seeking an enthusiastic candidate familiar with high-throughput approaches, ideally with topically relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and application requirements:

http://jobportal.ku.dk/alle-opslag/?show=904563

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014
(2) Marquardt et al. Mol Cell. 2014
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors

=='''Ph.D. Fellow in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
Project description
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is offering a 3-year Ph.D.-fellowship commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is funded by a Hallas-Møller Investigator Award to Sebastian Marquardt.
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark

The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . Our preliminary data support a Ph.D. position in any of these three focus areas within non-coding transcription research:

- Divergent lncRNA Transcription (1) 
- Functional Consequences of Non-Coding Transcription (2, 3) 
- Transcription Kinetics in Environmental Interactions (4) 

Please specify in your Cover Letter what attracts you for a Ph. D. in any of these focus areas. Our lab employs cutting edge budding yeast technology to identify the molecular mechanisms controlling transcription of non-coding sequences. The knowledge of non-coding transcription mechanisms helps us to study the functional roles of non-coding transcription. For example, we disrupt non-coding transcription in Arabidopsis to identify roles of non-coding transcription in plant environmental responses. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/

A successful candidate will be enthusiastic about the general research area, ideally with relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and requirements:
http://jobportal.ku.dk/alle-opslag/?show=904540

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014
(2) Marquardt et al. Mol Cell. 2014
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors
(4) Hazelbaker, Marquardt, et al. Mol Cell. 2013

=='''Postdoctoral position in synthetic biology. Montpellier, France. (posted january 20, 2017)''' ==

A post-doctoral position is available for 24 months at the “UMR-Sciences pour l’Œnologie de Montpellier” (UMR INRA 1083), in the Microbiology team, starting approximately in March 2017.

This work is part of a project financed by the “Agence Nationale de la Recherche” (ANR) (for details see ENZINVIVO project http://www.agence-nationale-recherche.fr/fileadmin/aap/2016/selection/aap-g-anr-DS10-selection-2016.pdf).
Enzyme reactions have long been analyzed in vitro, using pure enzymes and diluted buffer conditions. Due to the large amount of data generated and collected with thousands of enzymes, enzymology has made tremendous progress on understanding the incredible power of biocatalysts. However, dilute, in vitro conditions are far from the surroundings of natural enzymatic reactions that take place inside cells. The cellular medium is more accurately described as a heterogeneous crowded gel, dense and filled with all sorts of macromolecules and cellular lipidic organelles which may result in some partitioning effects and changes in diffusion. Therefore, enzymatic parameters determined using classical enzymology setups may not perfectly represent the real, in vivo based, rate and equilibrium constants. Although some advances have been made toward the comprehension of viscosity and crowding effects, we are still far to derive rate and equilibrium parameters from in vivo enzymatic reactions.
The project ENZINVIVO will address this issue focusing on two isoforms of phytoene synthase (carotenoid biosynthesis) as model enzymes. The enzymatic properties of these enzymes will be investigated in vitro, through a set of measurement in environments of increasing complexity and in vivo expressing the carotenoid biosynthesis pathway in S. cerevisiae and using synthetic biology tools and concepts to tune, at will, substrate and enzyme levels.
We aim at deciphering:
- how the intracellular medium influences enzymatic reactions.
- how can we build an in vivo approach to measure enzymatic parameters.
- how general models of enzymatic equations can be rewired to account for the complexity in vivo approaches. Our work will notably verify (or not) whether a Michaelis-Menten description of the kinetics remains valid in vivo.
The candidate will be first responsible for the construction of engineered strains with fine-tuned or inducible expression of CtrE (geranylgeranyl pyrophosphate synthase, GGPP synthase) to modulate intracellular concentration of GGPP, substrate of the phytoene synthase in a range consistent with its KM. Then, he/she will be in charge of analyzing the consequences of the heterologous pathway on the yeast physiology through multi-levels characterization of the recombinant strains.
Personal Qualifications
• A PhD in the fields of molecular biology, genetics or related fields
• Solid experience in metabolic engineering, omics approaches, and microbiology are highly desirable.
• Skills in yeast metabolism and experience in multi-partners collaborations will be also strongly appreciated.
• Ability to lead good oral and written communication skills, engaged and highly motivated.

Candidates please send a letter that describes your scientific interest and research experience, together with your CV, list of publications and the names of three references to Drs. Carole Camarasa (carole.camarasa@inra.fr) and Virginie Galeote (virginie.galeote@inra.fr).

Application deadline: 01/04/2017. Applications will be reviewed on an ongoing basis.

=='''Multiple post-doctoral research positions in budding yeast cell cycle biology, Trento, Italy - (posted October 24th, 2016)'''==

Multiple post-doctoral research positions are available in the laboratory of Prof. Peter De Wulf, which recently moved from the European Institute of Oncology (Milan, Italy) to the Centre for Integrative Biology (CIBIO), University of Trento (Trento, Italy (http://www.cibio.unitn.it)).

Available projects include the study of (i) how a minimally understood, conserved kinase regulates the timing of kinetochore assembly and re-organization during the ''S. cerevisiae'' cell cycle and (ii) how a novel and conserved ubiquitin-driven response pathway ensures kinetochore subunit homeostasis in ''S. cerevisiae''.

Knowledge of molecular biology, biochemistry, fluorescence (live-cell) microscopy and/or genetics is required. Additional experience with yeast cell cycle biology (mitosis or meiosis) is an advantage. Please send your curriculum vitae to peter.dewulf@unitn.it. For more information about the lab, please see http://www.cibio.unitn.it/510/chromosome-segregation-biology

=='''Postdoctoral Fellowship-Yeast Kinetochore Biology (posted 27 May 2016)''' ==
'''Postdoctoral Fellowship-Yeast Kinetochore Biology - The Francis Crick Institute, London.'''

Dr Thorpe’s laboratory focuses on kinetochore biology, mitosis and asymmetric cell division. Details of research projects currently being undertaken can be seen at: www.crick.ac.uk/peterthorpe. Research techniques used in the laboratory include high-throughput fluorescence imaging, genetics, genomics, and computational biology. The research aims to understand how kinetochores are assembled and maintained during cell division and to understand how kinetochore asymmetries affect chromosome segregation. In this project, some of the specific aims could include but are not limited to: 
• Identifying regulators of kinetochore protein asymmetry. 
• Characterise the role of protein modifications in directing kinetochore protein levels. 
• Elucidate the role of cell cycle processes in maintaining the kinetochore. 
• Examine the mechanistic links between chromatin and kinetochores. 

'''PERSON SPECIFICATION'''

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following: 

'''Essential''' 
• PhD in cell biology/genetics or in the final stages of PhD submission. 
• Good knowledge and experience in mathematical, statistical and data analysis. 
• Technical expertise in microbiology and/or genetics. 
• Track record of writing papers as evidenced by publications or submitted manuscripts in
referred journals. 
• Evidence of data presentation at scientific meetings. 
• Experience of experimental design. 
• Ability to work independently and also capable of interacting within a group. 
'''Desirable''' 
• Experience in genomics/high-throughput technologies. 
• Experience in using computational biology to work with large data sets. 
• Experience in synthetic biology and gene targeting. 
Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.
Deadline for applications is 27th June 2016. More details and online application process at https://jobs.crick.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.display_form?_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=002923&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y

=='''Postdoctoral Fellowship-Yeast Genetics meets protein therapeutics (posted 16 May 2016)''' ==
'''Postdoctoral Fellowship-Yeast Genetics meets protein therapeutics'''

The laboratories of Dr. Danny Chou and Jared Rutter in the Department of Biochemistry at the University of Utah are seeking a highly motivated postdoctoral researcher. This funded project focuses on using the awesome power of yeast genetics to discover and develop novel insulin variants with desirable therapeutic properties. This position will provide a unique opportunity to utilize experience with yeast genetics in developing new therapeutic agents for people with diabetes. A successful candidate must hold a Ph.D. in molecular biology, genetics or related fields. Preference will be given to those with experiences in yeast genetics. Candidates please send a letter that describes your scientific interest and research experience, together with your CV, list of publications and the names of three references to Drs. Danny Chou (dchou@biochem.utah.edu) and Jared Rutter (rutter@biochem.utah.edu).

=='''Postdoctoral position in evolutionary systems biology. Québec, Canada. (posted Feb 23, 2016)''' ==
'''Postdoctoral position in evolutionary genomics and systems biology in the Landry Laboratory'''

A postdoctoral position is available in the Landry Laboratory at Université Laval in Québec City under the Canada Research Chair in Evolutionary Cell and Systems Biology. The PDF will work on a project at the interface of genomics, cell biology and evolution to investigate the mechanisms of evolution of gene and protein networks. The specific project will be developed with the selected candidate. The selected candidate will combine experimental evolution, high-throughput screening and bioinformatics, and the budding yeast Saccharomyces cerevisiae as experimental model system. The candidate is expected to have a PhD in biology or a related discipline, and a strong background in molecular and cell biology with at least basic skills in bioinformatics and statistics (R, Python or Perl). The candidate should have strong leadership skills, motivation and creativity and be able to work in a team of collaborators. The Landry lab is located at the Institut de Biologie Intégrative et des Systèmes (IBIS) of Université Laval and is part of the Quebec Network for Research on Protein Function, Engineering, and Applications (PROTEO). IBIS and PROTEO offer very stimulating training environment and cutting edge technologies in genomics and proteomics. The Landry lab is an international team of 15 students, PDFs and research associates from different backgrounds (microbiology, biology, bioinformatics, biochemistry) addressing questions in evolutionary cell and systems biology.

The application package (1 single PDF file) should include a motivation letter demonstrating the interest of the candidate for the field and his/her ability to perform this type of research, a short project proposal (half a page), reprints of the candidate’s most important contributions, a CV and the contact information of three people who can provide letters of reference. The file should be sent to landrylaboratory@gmail.com

Starting date could be as early as June 2016. The competition will remain open until a candidate is selected.
For recent publications from the Landry lab, please visit:
http://landrylab.ibis.ulaval.ca/

=='''Postdoctoral position in Cell Biology and Genetics, Northern Kentucky University (posted May 7, 2015)''' ==
Laboratory of Erin Strome, Biological Sciences Department, Northern Kentucky University (Cincinnati Area)

A teaching-scholar faculty position is available to study mechanisms of haploinsufficiency induced genome instability. The position would be ideal for someone who will be pursuing a teaching and research balanced career and potentially be interested in a faculty job at an undergraduate institution. The postdoctoral fellow will have opportunities to develop their experimental and scientific credentials while also getting teaching experience and mentoring on teaching and lots of direct contact mentoring undergraduates in research lab projects.

Qualifications: Applicants should have a Ph.D. (ABD candidates will be considered) with a strong background in molecular biology/biochemistry/genetics and should be capable of conducting standard molecular biology tests including PCR and qPCR, Westerns, and siRNA experiments.

Please see https://jobs.nku.edu/postings/2817 for full job ad and application details.

Contact: Erin Strome, stromee1@nku.edu

Positions in yeast labs

2012-03-27T21:06:39Z

JHMcCusker:

=='''Laboratory Manager in Molecular Biology at Brown University'''==
March 2012: Position available in the laboratory of Tricia Serio, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI

The Laboratory Manager will have primary responsibility for managing the daily operation of the laboratory and for designing, conducting, and analyzing experiments to investigate cellular control of prion propagation in the yeast S. cerevisiae. The Laboratory Manager will also oversee and coordinate the activities of other laboratory personnel and the move of our laboratory to the Department of Molecular and Cell Biology, University of Arizona, Tucson, AZ during the summer of 2012. The position will continue at the UA.

Position requirements:
• MA, MS, or PhD in molecular biology, genetics, cell biology, biochemistry or related field
• 3-5 years full-time laboratory experience
• Competence in laboratory techniques such as DNA isolation and cloning, PCR, RNA isolation, RT-PCR, protein isolation/purification, gel electrophoresis, western blotting, immunoprecipitation, fluorescence imaging and quantitative microscopy techniques including FRAP and FLIP); experience with yeast preferred but not required
• Excellent organizational/record-keeping skills
• Excellent hand/eye coordination
• Excellent interpersonal skills
• Competence with computer programs such as FileMaker, Microsoft Word and Excel, Adobe Photoshop and Illustrator
• Excellent quantitative skills
• Self-motivated

Applications should be submitted through Human Resources at Brown University:
https://careers.brown.edu/applicants/jsp/shared/frameset/Frameset.jsp?time=1332257367295
position # M02626

=='''PhD student in Molecular Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden'''==
A PhD student position in Molecular Biology/Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Experimental investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Here the experimental platform generated in the project will be optimized, especially the formation of cell arrays of synchronized cells as well as image analysis. Using in parallel Mig1 and Msn2 reporters, response thresholds under different glucose levels will be establish and effects on cell-to-cell variability and bistability will be determined.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signalling, use of microfluidic devices, microscopy, image analysis, application of nano-sensor technology, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

=='''PhD student in Systems Biology (Marie Curie Early Stage Researcher)at the University of Gothenburg, Sweden'''==

A PhD student position in Systems Biology is available in the lab of Prof. Stefan Hohmann, Dept of Cell and Molecular Biology, University of Gothenburg, Sweden.

The research project “Theoretical investigation of the yeast Hxk2/Snf1/Mig1 network” aims to understand the dynamic control of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Data generated in the project will be interpreted by mathematical modelling together with other project partners to understand feedback and feed-forward mechanisms of signalling. Mutants and inhibitory compounds will be used to test how those affect thresholds and bistability. The analysis will reveal the genetic determination of the system properties, how they are regulated and how robustness against perturbation is established.

Requested Background(advantageous but not required): Yeast biology, yeast genetics, glucose signaling, microscopy, image analysis, development of mathematical models, ‘systems’ thinking.

The Marie Curie project ISOLATE is a collaborative research and training network between eight partners, incl. in different European countries. The PhD students and postdocs in the project will perform top-notch research and will additionally benefit from an excellent training network offered by the project partners. Research stays during the PhD projects in other partners’ labs are strongly encouraged. Primarily recruitment of researchers from EC Member States and associated countries, but also open to researchers from third countries. Researchers are normally required to move from one country to another when taking up the appointment.

Please send an application including (1) a max. one-page cover letter containing a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any,)(3) a copy of the passport or ID with picture, (4) two letters of recommendation, to maria.enge@gu.se (Project Manager in Prof. Hohmann's group).

=='''Postdoctoral position to study Ty1 retrotransposition at the University of Georgia''' ==

A postdoctoral position is available in the lab of David J. Garfinkel, Department of Biochemistry and Molecular Biology, University of Georgia, Athens GA to work on the retrovirus-like transposon Ty1 of ''Saccharomyces''. Specifically, we are investigating a new form of RNA-interference based on Ty1 antisense RNAs that acts posttranslationally and targets Ty1 proteins in the absence of the conserved RNAi pathways.

Experience in molecular genetics, protein/nucleic acid interactions or cytology would be helpful.

Also see our website for further information [http://www.bmb.uga.edu/home/people/people.php?fname=David&lname=Garfinkel]

Please send resume or inquiries to:

David J. Garfinkel

Department of Biochemistry and Molecular Biology

A130 Life Sciences

120 Green St.

University of Georgia

Athens, GA 30622

tel: 706-542-9403

djgarf@bmb.uga.edu

==Yeast Systems Biology Position at Virginia Tech (Research Associate or Sr Research Associate)==
The Synthetic Biology group at Virginia Bioinformatics Institute (VBI) is involved in two collaborative research projects focused on the development of mathematical models of gene-protein regulatory networks controlling cell growth and division. Temporal organization of the budding yeast cell cycle has been studied from two vantage points: bottom-up models emphasize a protein regulatory network centered around cyclin-dependent protein kinases, whereas top-down models focus on a gene regulatory network governed by interrelated transcription factors. The first project is focused on unifying these two perspectives. The second project is focused on the development of stochastic models of the regulatory network controlling the cell cycle. Both projects are performed in close collaboration with experts in computer science, data mining, bioinformatics, and mathematical modeling. The successful candidate will be expected to contribute significantly to these two projects by being responsible for designing and performing experiments used to validate model predictions. These experiments will involve the development of a new collection of cell cycle mutants and their quantitative characterization by time-lapse microscopy. In addition, the successful candidate will be expected to prepare the results for publication and presentation, to help supervise graduate and undergraduate students, and to contribute to grant proposals.

Dependent on the qualifications of the successful candidate, the position will hold the research faculty rank of either Research Associate or Senior Research Associate.

Go to the [http://bit.ly/n4nDUQ position description] for additional information and for submitting applications.

More information about our team can be found by visiting:
* [http://www.vbi.vt.edu/faculty/personal/Jean_Peccoud Jean Peccoud's home page]
* [http://www.biol.vt.edu/faculty/tyson/ John Tyson's home page]
* [https://bioinformatics.cs.vt.edu/~murali/ T.M. Murali's home page]

==Postdoctoral grants at the Max Planck Institute for Evolutionary Biology, Plön, Germany==
Post-doctoral grants are available for ambitious, motivated scientists to join Experimental Evolution Research Group. We can provide excellent research funding and support for projects that build on or complement our existing program. Positions are funded by the Max Planck Society for 2 years initially.

We use Saccharomyces yeasts as model organisms for evolution and ecology. ''Saccharomyces cerevisiae'' is probably the best known and most tractable model organism used in biology, but its life outside the laboratory is poorly understood. We study the evolution of various interesting yeast traits using both laboratory experiments and observations of wild yeast. For a primer on yeast evolutionary biology, and to understand the motivation for our research please read Greig, D. & Leu, J-Y. (2009) “Natural history of budding yeast” Curr. Biol. 19:R886-890. For our current work, please see our [http://www.evolbio.mpg.de/expevolution/Greig/Welcome.html lab web page]

The Max Planck Institute for Evolutionary Biology offers outstanding infrastructure and facilities, and is attractively located in Northern Germany, in a lake district near the Baltic coast. It is well connected by train to the university towns of Lübeck and Kiel, and Hamburg is the nearest major airport.

Applicants must have a PhD and at least one peer-reviewed publication in the field of evolution, ecology, or yeast genetics. Applicants should prepare a short (<500 word) research proposal, a CV, and contact details for three academic referees. They should combine these into a single PDF file and send it by email to Duncan Greig (d.greig@evolbio.mpg.de). Informal enquiries can be made to any member of the Research Group. Applications will be considered until suitable candidates are found. September 2011

==Postdoctoral position==
SEPTEMBER 2011: A postdoctoral position is available in the laboratory of Claudio Joazeiro, Department of Cell Biology, The Scripps Research Institute (San Diego, California).

Research in the laboratory addresses the function of E3 ubiquitin ligases in biology and disease.

The position available is to elucidate the functions and mechanisms of the E3 ligase LISTERIN. We had previously reported on a new mouse model of neurodegeneration caused by mutation of Listerin/Ltn1, a novel E3 (Chu et al. 2009). Homozygous mutant mice exhibit profound early-onset and progressive neurological and motor dysfunction. The focus of our most recent work has been on elucidating this E3’s critical biological role(s) and determining how defects in its function lead to the disease. Listerin/Ltn1 is conserved in all eukaryotes, so we have taken advantage of budding yeast and found that the E3 is ribosome-associated and functions in the quality control of a specific subset of aberrant, nascent proteins (Bengtson & Joazeiro 2010). Currently, we undertake biochemistry, yeast genetics, mammalian tissue culture and genomic approaches to continue our characterization of Listerin/Ltn1, and are positioned to readily test the relevance of the discoveries we make for neurodegeneration using the mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Selected references:
*Bengtson MH & Joazeiro CA. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467:470-3.
*Deshaies RJ & Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu Rev Biochem. 78:399-434.
*Chu J et al. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. PNAS 106:2097-103.

The candidate should be independent, hard working, proactive and productive, and should have strong conceptual and experimental background in biochemistry and molecular biology.

Please send CV, a 1-page statement of current and future research interests, and the names and contact information of three references to: 
Claudio Joazeiro 
c/o Miriam Berba (Email: mirberba@scripps.edu) 
The Scripps Research Institute, CB-163 
10550 N Torrey Pines Rd 
La Jolla, CA 92037 USA

==Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France==
Postdoctoral position is available in the Laboratory of Cell Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the fission yeast S. pombe. The roles of the Rho GTPase, actin polymerisation, and myosin will be studied. The work will involve genetics, cell biology, microscopy, microfabrication and microfluidics; for more information, send a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

Positions in yeast labs

2011-08-04T19:46:36Z

JHMcCusker:

==Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France==
Postdoctoral position is available in the Laboratory of Cell
Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the
fission yeast S. pombe. The roles of the Rho GTPase, actin
polymerisation, and myosin will be studied. The work will involve
genetics, cell biology, microscopy, microfabrication and
microfluidics; for more information, send a CV and contact information
of referees to Dr. Daniel Riveline (riveline@unistra.fr)

==Technician Position - Yeast Cell Biology - London UK==
A research technician position is available in the Thorpe lab at the MRC National Institute for Medical Research, Mill Hill, London (http://www.nimr.mrc.ac.uk/research/peter-thorpe/). The lab uses the yeast, ''Saccharomyces cerevisiae'' to study fundamental aspects of cell division. The project is focussed upon identifying the molecular pathways that control asymmetric cell division. We employ a combination of yeast genomics approaches and high-throughput fluorescence microscopy to identify the genes responsible for asymmetry in yeast. The work involves supporting the goals of the lab and will include yeast genetics, genomics, fluorescence imaging and image analysis. Preference will be given to candidates with strong computer-based skills including the use of standard office software, DNA sequence analysis, database management and image analysis.

Applications are handled by the RCUK Shared Services Centre; to apply please visit the job board at https://ext.ssc.rcuk.ac.uk and complete an online application form. Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003. Please quote reference number IRC23869.

Closing date for applications is 4th July, 2011.

==Yeast quantitative genetics post-doctoral positions at Duke University Medical Center==
Positions are available for post-docs to work on a recently NIH funded grant “High throughput S. cerevisiae HAM, GWA & QT/QTL architecture resource”. Our understanding of quantitative traits, which includes pharmacogenetic variations in human drug efficacy and side effects, is poor. Improving our understanding of quantitative traits and of pharmacogenetics is aided by tractable model systems, such as Saccharomyces cerevisiae. In this study, we develop a novel S. cerevisiae genetic resource population for high throughput haploid association mapping (HAM) and genome wide association (GWA).

We will use the high quality genome sequences of 96 S. cerevisiae strains to generate a novel genetic resource population that we will use to perform high throughput determination of quantitative trait (QT) and quantitative trait loci (QTL) architecture. Start dates are open. Candidates should have recently received their Ph.D. (0 to – at most – 4 years) and should have expertise in yeast genetics/molecular biology and/or quantitative/population genetics. Candidates should email their curriculum vitae (pdf), including the names and contact information for three references, to John McCusker at mccus001@mc.duke.edu.

We are also looking a bioinformatician to join the outstanding team of fungal researchers at Duke University in a position in comparative yeast genomics on an NIH funded project. This project will involve working with the groups of Drs. John McCusker, Fred Dietrich, and Paul Magwene. We are looking for an individual with either a PhD or a MS degree with a strong background in computer science, bioinformatics, and genetics.

The project involves assembly and annotation of complete Saccharomyces cerevisiae genome sequences from next generation sequence data. This project is both computationally challenging, as well as requiring in-depth knowledge of the organism. Good programming skills and project management skills as well bioinformatics skills are necessary.

Candidates should send their CV, including the names and contact information for three references, to Fred Dietrich (fred.dietrich@duke.edu)

Positions in yeast labs

2011-08-04T19:45:44Z

JHMcCusker:

==Postdoctoral position - Laboratory of Cell Physics - Strasbourg, France==
Postdoctoral position is available in the Laboratory of Cell
Physics, ISIS/IGBMC, Strasbourg, France. The project will focus on the dynamics of the cytokinetic ring in the
fission yeast S. pombe. The roles of the Rho GTPase, actin
polymerisation, and myosin will be studied. The work will involve
genetics, cell biology, microscopy, microfabrication and
microfluidics; for more information, send a CV and contact information
of referees to Dr. Daniel Riveline (riveline@unistra.fr)

==Technician Position - Yeast Cell Biology - London UK==
A research technician position is available in the Thorpe lab at the MRC National Institute for Medical Research, Mill Hill, London (http://www.nimr.mrc.ac.uk/research/peter-thorpe/). The lab uses the yeast, ''Saccharomyces cerevisiae'' to study fundamental aspects of cell division. The project is focussed upon identifying the molecular pathways that control asymmetric cell division. We employ a combination of yeast genomics approaches and high-throughput fluorescence microscopy to identify the genes responsible for asymmetry in yeast. The work involves supporting the goals of the lab and will include yeast genetics, genomics, fluorescence imaging and image analysis. Preference will be given to candidates with strong computer-based skills including the use of standard office software, DNA sequence analysis, database management and image analysis.

Applications are handled by the RCUK Shared Services Centre; to apply please visit the job board at https://ext.ssc.rcuk.ac.uk and complete an online application form. Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003. Please quote reference number IRC23869.

Closing date for applications is 4th July, 2011.

==Yeast quantitative genetics post-doctoral positions at Duke University Medical Center==
Positions are available for post-docs to work on a recently NIH funded grant “High throughput S. cerevisiae HAM, GWA & QT/QTL architecture resource”. Our understanding of quantitative traits, which includes pharmacogenetic variations in human drug efficacy and side effects, is poor. Improving our understanding of quantitative traits and of pharmacogenetics is aided by tractable model systems, such as Saccharomyces cerevisiae. In this study, we develop a novel S. cerevisiae genetic resource population for high throughput haploid association mapping (HAM) and genome wide association (GWA).

We will use the high quality genome sequences of 96 S. cerevisiae strains to generate a novel genetic resource population that we will use to perform high throughput determination of quantitative trait (QT) and quantitative trait loci (QTL) architecture. Start dates are open. Candidates should have recently received their Ph.D. (0 to – at most – 4 years) and should have expertise in yeast genetics/molecular biology and/or quantitative/population genetics. Candidates should email their curriculum vitae (pdf), including the names and contact information for three references, to John McCusker at mccus001@mc.duke.edu.

We are looking a bioinformatician to join the outstanding team of fungal researchers at Duke University in a position in comparative yeast genomics on an NIH funded project. This project will involve working with the groups of Drs. John McCusker, Fred Dietrich, and Paul Magwene. We are looking for an individual with either a PhD or a MS degree with a strong background in computer science, bioinformatics, and genetics.

The project involves assembly and annotation of complete Saccharomyces cerevisiae genome sequences from next generation sequence data. This project is both computationally challenging, as well as requiring in-depth knowledge of the organism. Good programming skills and project management skills as well bioinformatics skills are necessary.

Candidates should send their CV, including the names and contact information for three references, to Fred Dietrich (fred.dietrich@duke.edu)

Positions in yeast labs

2011-06-14T16:03:54Z

JHMcCusker:

==Yeast quantitative genetics post-doctoral positions at Duke University Medical Center==
Positions are available for post-docs to work on a recently NIH funded grant “High throughput S. cerevisiae HAM, GWA & QT/QTL architecture resource”. Our understanding of quantitative traits, which includes pharmacogenetic variations in human drug efficacy and side effects, is poor. Improving our understanding of quantitative traits and of pharmacogenetics is aided by tractable model systems, such as Saccharomyces cerevisiae. In this study, we develop a novel S. cerevisiae genetic resource population for high throughput haploid association mapping (HAM) and genome wide association (GWA).

We will use the high quality genome sequences of 96 S. cerevisiae strains to generate a novel genetic resource population that we will use to perform high throughput determination of quantitative trait (QT) and quantitative trait loci (QTL) architecture. Start dates are open. Candidates should have recently received their Ph.D. (0 to – at most – 4 years) and should have expertise in yeast genetics/molecular biology and/or quantitative/population genetics. Candidates should email their curriculum vitae (pdf), including the names and contact information for three references, to John McCusker at mccus001@mc.duke.edu.

==Institute of Genetics and Biotechnology, University of Warsaw, Poland==
Positions for two (2) young (up to 4 years after doctorate) post-docs, three (3) Ph.D. students and two (2) M.Sc. students to work on the EU-funded project "Yeasts - an evolutionary laboratory for studying nucleo-mitochondrial interactions" to study the co-evolution of nuclear-encoded mitochondrial gene-expression factors and the mitochondrial genome in different yeast species, to analyze the mechanisms of mitochondrial RNA processing, and to propose yeast models for human mitochondrial disorders.
For details see our website at [http://team.igib.uw.edu.pl/]. Application deadline 13 June 2011.

== Institute of Environmental Sciences at the Jagiellonian University, Kraków, Poland ==
The leading Polish institute in: Behavioral ecology, Evolutionary genetics and life histories, Physiological and bioenergetics, Ecotoxicology and industrial pollutants, Ecosystem ecology, environmental education and management Is opening applications for:
* 4-year interdisciplinary doctoral studies programme in ecology in English, with net-scholarships 2200 PLN per month, offering research in Poland and half-year placements in academic centres outside Poland and a choice of 4 out of 8 courses from different scientific disciplines conducted by eminent Polish and foreign specialists Application deadline: 10 June 2011
* 20-month fellowship programme for strongly motivated scientists with a PhD degree in Biology, Ecology or related field, with net-fellowship 3200 PLN per month plus social benefits, realized in one of the research groups at the Institute of Environmental Sciences and a monthly internship at the universities in Europe and the U.S. Application deadline: 29 April 2011

Detailed information, containing the description of research projects proposed for PhD students, profile of the applicant and the application instructions are available at: www.eko.uj.edu.pl/ecology

„Launching interdisciplinary doctoral studies programme in ecology in English and increasing the didactic potential of the staff of the Institute of Environmental Sciences at the Jagiellonian University”
Project co-financed by the European Union under the European Social Fund

== Postdoctoral positions for an ERC-funded project: Yeast chromatin/epigenetics - Nicosia, Cyprus - [http://www.nature.com/naturejobs/science/jobs/159862-Postdocs-in-chromatin-and-epigenetics] ==
Positions for two (2) highly motivated Postdocs to work on the project ´Functional and regulatory protein networks of chromatin modifying enzymes´in the group of Dr Antonis Kirmizis (http://www.ucy.ac.cy/en-US/~kirmizis.aspx ). The post holders will elucidate novel epigenetic mechanisms in yeast using state-of-the-art genetic, proteomic, and genomic methods.
The successful applicants should have a PhD Degree in molecular biology or related areas. Previous research experience in the field of chromatin and/or knowledge of yeast genetics and molecular biology will be considered an advantage.
The positions are initially available for 2 years with the possibility to extend it to 5 years (subject to satisfactory progress). The starting gross salary for the position is €2,782 per month. The anticipated start date of the project is 03/01/2011 (this is negotiable).
To apply, mail a cover letter, CV and contact details for at least 2 references to Human Resources Services, University of Cyprus, Anastasios G Leventis Building, P.O. Box 20537,
1678 Nicosia, Cyprus by 15 October 2010.

== Postdoctoral position: Yeast synthetic biology / Experimental evolution : Houston, TX, USA - [http://www.nature.com/naturejobs/science/jobs/122071-Postdoctoral-position-Interdisciplinary-research-Synthetic-Biology-Experimental-evolution] ==

== Multiple Postdoctoral Positions: University of Toronto / Harvard Medical School collaboration ==
Multiple postdoctoral positions are available within a collaboration led by faculty at either the Terrence Donnelly Centre for Cellular and Biomolecular Research or the Samuel Lunenfeld Research Institute together with Dr. Frederick Roth (Harvard Medical School, Dept of Biological Chemistry and Molecular Biology). Positions are in Toronto, ON but are collaborative and may initially require travel to Harvard Medical School in Boston, MA.

Postdoctoral Fellow – Pathway Genomics.
Applicants should have substantial experience in molecular genetics and strong intellectual interest in systematic genetic approaches to characterize gene function, pathway order and drug mechanism. Potential projects include: 1) systematic measurement of synergistic drug combinations in human cell lines; 2) development of a deep sequencing approach for measuring genetic interactions; and 3) using deep sequencing to efficiently screen for kinase-dependent protein interactions.

Postdoctoral Fellow – Synthetic Biology.
Applicants should have substantial experience in molecular genetics, and strong intellectual interest in the use of synthetic biology and genetic analysis to characterize gene function, pathway order, and drug mechanism. Potential projects include: a strategy for rapid production of strains in which many genes have been precisely re-engineered, in order to study multigenic genetic interactions and reconstruct pathways from human and other genetically recalcitrant systems; implementation of a physical genetic algorithm to optimize reconstructed or synthetic pathways. Potential applications include the study of drug resistance and metabolism or development of synthetic tools for large-scale genetic perturbation analysis.

Postdoctoral Fellow – Computational Genomics.
Seeking a creative and talented postdoctoral fellow interested in using causal reasoning to reveal cellular pathways and drug mechanism of action via integration and analysis of large-scale genomic and proteomic experiments. Involves large-scale data from ongoing collaborations on protein interaction mapping, high-content cellular and organismal phenotyping, protein expression and metabolite profiling, and discovery of genetic interactions to identify and characterize biological pathways. Qualifications are a track record of imaginative quantitative research and a solid foundation in a substantial subset of computer science, mathematics, statistics, genetics and molecular biology.

To apply for any of these positions, please submit a curriculum vitae and contact information for three references to fritz_roth@hms.harvard.edu.
http://llama.med.harvard.edu/positions.html

(posted April 23, 2010)
== Postdoctoral Position in Cell Biology (Yeast) : IGBMC, Strasbourg, France==

A postdoctoral position is open in Strasbourg (France) at the European Center, Institute
of Genetics and Molecular and Cellular Biology (IGBMC): the project will focus on the
dynamics of the cytokinetic ring in the fission yeast ''S. pombe''. The roles of the GTPase
Rho, actin polymerisation, and myosin will be studied. The work will involve genetics,
cell biology, microscopy, microfabrication and microfluidics; for more information, send
a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

== '''PhD and Postdoctoral positions, Institute of Environmental Sciences at the Jagiellonian University, Kraków, Poland''' ==

“-Molecular mechanisms of genetic and environmental interactions for fitness in the budding yeast ''S. cerevisiae''” in the laboratory of professor Ryszard Korona

Institute of Environmental Sciences at the Jagiellonian University is opening applications for: 4-year interdisciplinary doctoral studies programme in ecology in English, with net-scholarships 2200 PLN per month, offering research in Poland and half- year placements in academic centres outside Poland and a choice of 4 out of 8 courses from different scientific disciplines conducted by eminent Polish and foreign specialists
Application deadline: 10 June 2010

20-month fellowship programme for strongly motivated scientists with a PhD degree in Biology, Ecology or related field, with net- fellowship 3200 PLN per month plus social benefits, realised in one of the research groups at the Institute of Environmental Sciences and a monthly internship at universities in Europe and the U.S.
Application deadline: 30 April 2010

Detailed information, containing the list of all research topics proposed for PhD students, profile of the applicant and application instructions is available at http://www.eko.uj.edu.pl/ecology/.

Project co-financed by the European Union under the European Social Fund

= Postdoctoral research position, Harvard University=

Postdoctoral research position is available for a scientist to
investigate host-pathogen interactions using C. elegans (J Exp Med
2009, 206:637-53; PNAS 2008,105:14585-90; PLoS Pathog. 2007, 3:e101
and e18; Eukaryot Cell 2009;8:732-7). Please send letter of
application, curriculum vitae, statement of research interests, and
have 3 current letters of professional reference emailed to
Dr. E. Mylonakis emylonakis[AT]partners.org. (posted September 2, 2009)

MGH is an AA/EEO employer.

[http://www2.massgeneral.org/id/labs/mylonakis/ http://www2.massgeneral.org/id/labs/mylonakis]

[http://chemicalbiology.mgh.harvard.edu/labs-mylonakis.htm http://chemicalbiology.mgh.harvard.edu/labs-mylonakis.htm]

= Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge=

Postdoctoral Research Associate in the group of Dr Janneke Balk, Department of Plant Sciences, University of Cambridge

Salary: £27,183-£35,469 pa Limit of tenure: grant funding is available for 3 years in the first instance. Start date: 1 January 2010

Applicants must have a PhD, and a background in fungal genetics will be highly preferred. Previous experience in molecular biology and biochemistry methods is essential. This project is funded by the Wellcome Trust and includes part-time technical assistance.

The assembly of iron-sulphur cofactors in respiratory complex I

Complex I deficiencies are the most common cause of respiratory chain dysfunction, but how this largest of the respiratory complexes is assembled, including its unique chain of eight iron-sulphur (Fe-S) clusters, is poorly understood. This project aims to investigate the assembly of complex I using the yeast Yarrowia lipolytica as a genetic model organism, and will focus on: 1) Further analysis of the molecular role of Ind1, a recently identified Fe-S scaffold protein important for complex I assembly in Yarrowia and human cell lines (Bych et al 2008; Sheftel et al, unpublished). 2) Development of Yarrowia yeast as a genetic model organism to perform forward genetics screens, complemented by a biochemical approach, to identify additional complex I assembly factors, in particular those that assist Ind1 with Fe-S cluster insertion. 3) Translation of the findings to human disease: identification of human orthologues and whether they are implicated in complex I disorders.

This project involves collaborations with Dr Judy Hirst at the MRC Cambridge (in vitro cluster assembly in complex I subunits), Professor Ulrich Brandt, Frankfurt (complex I function and genetics in Yarrowia yeast) and Professor Jan Smeitink, Nijmegen (translation of the findings to human respiratory disease).

Dr Janneke Balk started an independent research group in 2005, focussing on Fe-S protein biogenesis in (higher) eukaryotes. Her dynamic and international group is rapidly expanding and moving to new laboratory space this autumn.

The University of Cambridge is a world-class research institute, which is particulary strong in biomedical sciences.

Reference: Bych K, Kerscher S, Netz DJA, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U and Balk, J (2008). The iron-sulfur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736-46.

For further enqueries: Janneke Balk, jb511@cam.ac.uk To apply, see http://www.plantsci.cam.ac.uk/jobs/content.html

=Postdoctoral Position at University of Texas Health Science Center at San Antonio=

A postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine morphology and virulence of ''Candida albicans'', the major fungal pathogen, in response to host environmental cues (for additional details see Carlisle, et al., PNAS 106:599-604 (2009)[http://www.pnas.org/content/106/2/599.long], Banerjee et al., MBC 19:1354-1365 (2008)[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18216277] and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis.

Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis, as well as ''S. cerevisiae'' researchers interested in transitioning to fungal pathogenesis, are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu).

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

=Postdoctoral or Staff Scientist Position at Purdue University=

Postdoctoral/Staff scientist position available in yeast functional genomics of chromosome segregation at Purdue University. Project goals are to define, on a global scale, the effect of phosphorylation by the Aurora kinase on protein interactions controlling chromosome segregation process in yeast. Project is funded for up to five years by NIH and will involve high-throughput screening and lab automation, genome-wide studies, microscopy, yeast molecular biology and bioinformatic analysis. Applicants should have a recent PhD in any field of biology that includes a strong conceptual and experimental background in Genetics, and/or Molecular and Cell Biology.

Applicants should send a CV by email to Dr. Tony Hazbun listed at the following web site:
http://www.mcmp.purdue.edu/faculty/?uid=hazbun

=Postdoctoral Position at Rutgers University=

A postdoctoral position is available at the Biotech Center at Rutgers University in the laboratory of Dr. Nilgun E. Tumer to investigate the mechanisms of uptake, transport and cytotoxicity of ricin and Shiga-like toxins. The Tumer lab works on elucidating the basic mechanisms of action of ricin and Shiga-like toxins using Saccharomyces cerevisae and C. elegans as model systems. Both toxins depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. Our goal is to identify the targets of these toxins to understand the mechanism by which they kill cells and to develop therapeutic intervention strategies. The successful candidate will use genetic, cell biology and chemical genomic approaches to investigate the mechanism of uptake and transport of the toxins in yeast and C. elegans and use chemical genomics approaches to identify the cellular pathways affected by these toxins. The ideal candidate should have a Ph.D. in a related field, experience with yeast and/or C.elegans genetics and cell biology and familiarity with chemical biology approaches. The Biotech Center is located in New Brunswick, New Jersey near New York City and Philadelphia and is equipped with state-of-the-art facilities and instrumentation. Rutgers University is an equal opportunity employer that strongly encourages underrepresented groups to apply for open positions.

Interested applicants should send their CV and names and addresses of three references to Dr. Nilgun E. Tumer (tumer@aesop.rutgers.edu). Information on our research can be found at: http://biotech.rutgers.edu/faculty/tumer.html, http://aesop.rutgers.edu/~plantbiopath/faculty/tumer/TUMER.HTML, http://lifesci.rutgers.edu/~molbiosci/faculty/tumer.html
Contact: Nilgun Tumer, Foran Hall, Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520. Tel: 732-932-8165 X215.

=Postdoctoral Position, Chemical Genomics=

Research Department: Molecular Ligand Target Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute
Dr. Charles Boone, Visiting Scientist
Dr. Minoru Yoshida, Team Leader

Location: RIKEN Advanced Science Institute, RIKEN Wako Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan

Area of Research: Chemical genetics and chemical genomics

Job Description: A postdoctoral researcher position is open in the field of chemical genomics. We have constructed a unique chemical library based on natural products in the Department of Chemical Biology, RIKAN Advanced Science Institute. The successful candidate will carry out original research on global analysis of drug-target interaction using the chemical library and various yeast mutants or transformants.

Selection Process: Candidates will be selected based on research results, publications, letters of recommendation (preferably in English), etc. The CV (preferably detailed and complete) and publications must be in English.

Application Deadline: Applications are now being accepted. Position will be closed after a suitable candidate is found.

Start of Employment: Immediately

Contract Conditions: Full-time employment with the contract shall be for one year, renewable annually upon evaluation until the end of the project (March 2012). Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Moving expenses to RIKEN will be reimbursed. Social insurance will also be applicable. Days off include public holidays, New Year's holidays (Dec. 29-Jan 3), summer holidays and RIKEN Foundation Day. These and other employment provisions are in accordance with RIKEN regulations.

Information at Web: Information on our team can be found on our website (http://www.riken.go.jp/engn/r-world/research/lab/asi/chemical/index.html)

Applications: Electronic copies of your curriculum vitae/résumé, a list of publications, two or three representative publications, and two reference letters should be sent to the address below or via e-mail to "charlie.boone" (add @utoronto.ca" to complete the address):
Charles Boone
Professor, University of Toronto, Donnelly CCBR
160 College St, Rm 1306
Toronto, ON
M5S 3E1

Notes: The documents you submit will be handled with the utmost care in accordance with RIKEN's rules for the protection of personal data and will be used only for employment screening purposes. This information will not be divulged, assigned, or loaned to a third party without legitimate reason.

=Postdoctoral Position: Engineering sea lamprey antibodies=

A vacant postdoctoral position at the Center of Marine Biotechnology in Baltimore to characterize antigen binding properties of VLR, the unique variable lymphocyte receptors of sea lamprey. The successful candidate will join a study with the goal to explore biotechnology applications for these novel antibodies (Pancer & Mariuzza, Nat. Biotechnol., 2008; Rogozin et al., Nat. Immunol., 2007; Alder et al., Science 2005; Pancer et al., Nature 2004). Our research platform includes yeast displayed recombinant VLR libraries that are screened with various antigens. Biochemical and structural properties of monoclonal VLRs are then characterized.

Candidates must have a PhD with solid background in protein biochemistry and molecular biology, experience in recombinant protein expression and characterization, and relevant peer-reviewed publications.

To apply for position #300957 please submit a letter describing your research interests and experience, an updated curriculum vitae and names of three references via http://www.cytiva.com/umbi/ext/detail.asp?jobid=umbi300957

Contact: Zeev Pancer, PhD
Center of Marine Biotechnology, UMBI
Columbus Center, Suite 236
701 East Pratt St. Baltimore, MD 21202, USA
Office: 410-234-8834; Fax: 410-234-8896
Email: pancer@comb.umbi.umd.edu

=Epigenetic Postdoctoral Fellow Posting=

'''Postdoctoral positions''' are available at Massachusetts General Hospital Cancer Center. My laboratory is focused on understanding the impact that both methylation and acetylation dynamics has in both human cell culture and C. elegans. In particular, the laboratory is investigating the impact that the histone 3 lysine 9/36 tri-demethylases [JMJD2A-D; Whetstine et al., (2007) Cell 125: 467-81] have on tumorigenesis, transcriptional regulation, and genomic integrity. The laboratory will interrogate the role of these enzymes by using genomic, proteomic, cytological and genetic approaches. Similar approaches allowed an important link to be established for histone deacetylase 1 (HDAC-1) and the regulation of extra-cellular matrix biology in both human and C. elegans, which has direct implications in cancer chemotherapy [Whetstine et al., (2005) Mol. Cell 18:483-90]. The laboratory will continue to investigate the functional overlap or unique pathways that the C. elegans class I histone deacetylases regulate by using the same type of approaches. Overall, the laboratory will integrate a number of approaches and systems to determine the important biological pathways regulated by histone demethylases and histone deacetylases.

The laboratory is looking for highly motivated, tenacious scientists that are enthusiastic, team players and love science. The laboratory is looking for researchers with documented proficiency in any of the following areas (basic molecular biology, protein biochemistry, genomics, epigenetics, C. elegans, cytology, development biology, DNA damage and repair) but interested in learning new approaches or systems to answer the exciting questions before us.

Requirements:
For these positions a Ph.D. and/or M.D. is required. These positions require enthusiastic, self motivated, independent thinkers with strong interpersonal skills, and the ability to communicate with laboratory members, national and international collaborators. Please have three letters of recommendation sent to the below address and/or e-mail.

Johnathan R. Whetstine, Ph.D.
Assistant Professor of Medicine
Harvard Medical School and
Massachusetts General Hospital Cancer Center
Building 149, 13th Street , Room 7-213
Charlestown, MA 02129, USA
Office Phone: 617-643-4374
jwhetstine@hms.harvard.edu

= B.A./B.S. Yeast Biochemist at Gevo, Inc., Englewood, CO, USA=

Gevo, Inc. is a high energy, team-oriented company that is pioneering the advanced green energy industry. We are looking for a term (up to one year) Biocatalyst Development Biochemist, based in Englewood, Colorado. This role is responsible for execution of analysis of metabolites on yeast biocatalysts under the direction of a senior scientist. This person will characterize yeast biocatalysts for their intra- and extracellular metabolite production, genotypes, and phenotypes. This position is considered a term position for up to one year.

Requirements include:
Bachelor degree in Biochemistry, Chemistry, Biotechnology, Microbiology or related field and 1 – 3 years of professional work experience in a lab, working with biochemical techniques and yeast. A detailed job description can be found at [http://www.gevo.com/careers.php#BDT]

Positions in yeast labs

2011-06-10T16:07:25Z

JHMcCusker:

==Yeast quantitative genetics post-doctoral positions at Duke University Medical Center==
Positions are available for post-docs to work on a recently NIH funded grant “High throughput S. cerevisiae HAM, GWA & QT/QTL architecture resource”. Our understanding of quantitative traits, which includes pharmacogenetic variations in human drug efficacy and side effects, is poor. Improving our understanding of quantitative traits and of pharmacogenetics is aided by tractable model systems, such as Saccharomyces cerevisiae. In this study, we develop a novel S. cerevisiae genetic resource population for high throughput haploid association mapping (HAM) and genome wide association (GWA).

We will use the high quality genome sequences of 96 S. cerevisiae strains to generate a novel genetic resource population that we will use to perform high throughput determination of quantitative trait (QT) and quantitative trait loci (QTL) architecture. Start dates are open. Candidates should have recently received their Ph.D. (0 to – at most – 4 years) and should have expertise in yeast genetics/molecular biology and/or quantitative/population genetics. Candidates should email their curriculum vitae (pdf), including the names and contact information for three references, to mccus001@mc.duke.edu.

==Institute of Genetics and Biotechnology, University of Warsaw, Poland==
Positions for two (2) young (up to 4 years after doctorate) post-docs, three (3) Ph.D. students and two (2) M.Sc. students to work on the EU-funded project "Yeasts - an evolutionary laboratory for studying nucleo-mitochondrial interactions" to study the co-evolution of nuclear-encoded mitochondrial gene-expression factors and the mitochondrial genome in different yeast species, to analyze the mechanisms of mitochondrial RNA processing, and to propose yeast models for human mitochondrial disorders.
For details see our website at [http://team.igib.uw.edu.pl/]. Application deadline 13 June 2011.

== Institute of Environmental Sciences at the Jagiellonian University, Kraków, Poland ==
The leading Polish institute in: Behavioral ecology, Evolutionary genetics and life histories, Physiological and bioenergetics, Ecotoxicology and industrial pollutants, Ecosystem ecology, environmental education and management Is opening applications for:
* 4-year interdisciplinary doctoral studies programme in ecology in English, with net-scholarships 2200 PLN per month, offering research in Poland and half-year placements in academic centres outside Poland and a choice of 4 out of 8 courses from different scientific disciplines conducted by eminent Polish and foreign specialists Application deadline: 10 June 2011
* 20-month fellowship programme for strongly motivated scientists with a PhD degree in Biology, Ecology or related field, with net-fellowship 3200 PLN per month plus social benefits, realized in one of the research groups at the Institute of Environmental Sciences and a monthly internship at the universities in Europe and the U.S. Application deadline: 29 April 2011

Detailed information, containing the description of research projects proposed for PhD students, profile of the applicant and the application instructions are available at: www.eko.uj.edu.pl/ecology

„Launching interdisciplinary doctoral studies programme in ecology in English and increasing the didactic potential of the staff of the Institute of Environmental Sciences at the Jagiellonian University”
Project co-financed by the European Union under the European Social Fund

== Postdoctoral positions for an ERC-funded project: Yeast chromatin/epigenetics - Nicosia, Cyprus - [http://www.nature.com/naturejobs/science/jobs/159862-Postdocs-in-chromatin-and-epigenetics] ==
Positions for two (2) highly motivated Postdocs to work on the project ´Functional and regulatory protein networks of chromatin modifying enzymes´in the group of Dr Antonis Kirmizis (http://www.ucy.ac.cy/en-US/~kirmizis.aspx ). The post holders will elucidate novel epigenetic mechanisms in yeast using state-of-the-art genetic, proteomic, and genomic methods.
The successful applicants should have a PhD Degree in molecular biology or related areas. Previous research experience in the field of chromatin and/or knowledge of yeast genetics and molecular biology will be considered an advantage.
The positions are initially available for 2 years with the possibility to extend it to 5 years (subject to satisfactory progress). The starting gross salary for the position is €2,782 per month. The anticipated start date of the project is 03/01/2011 (this is negotiable).
To apply, mail a cover letter, CV and contact details for at least 2 references to Human Resources Services, University of Cyprus, Anastasios G Leventis Building, P.O. Box 20537,
1678 Nicosia, Cyprus by 15 October 2010.

== Postdoctoral position: Yeast synthetic biology / Experimental evolution : Houston, TX, USA - [http://www.nature.com/naturejobs/science/jobs/122071-Postdoctoral-position-Interdisciplinary-research-Synthetic-Biology-Experimental-evolution] ==

== Multiple Postdoctoral Positions: University of Toronto / Harvard Medical School collaboration ==
Multiple postdoctoral positions are available within a collaboration led by faculty at either the Terrence Donnelly Centre for Cellular and Biomolecular Research or the Samuel Lunenfeld Research Institute together with Dr. Frederick Roth (Harvard Medical School, Dept of Biological Chemistry and Molecular Biology). Positions are in Toronto, ON but are collaborative and may initially require travel to Harvard Medical School in Boston, MA.

Postdoctoral Fellow – Pathway Genomics.
Applicants should have substantial experience in molecular genetics and strong intellectual interest in systematic genetic approaches to characterize gene function, pathway order and drug mechanism. Potential projects include: 1) systematic measurement of synergistic drug combinations in human cell lines; 2) development of a deep sequencing approach for measuring genetic interactions; and 3) using deep sequencing to efficiently screen for kinase-dependent protein interactions.

Postdoctoral Fellow – Synthetic Biology.
Applicants should have substantial experience in molecular genetics, and strong intellectual interest in the use of synthetic biology and genetic analysis to characterize gene function, pathway order, and drug mechanism. Potential projects include: a strategy for rapid production of strains in which many genes have been precisely re-engineered, in order to study multigenic genetic interactions and reconstruct pathways from human and other genetically recalcitrant systems; implementation of a physical genetic algorithm to optimize reconstructed or synthetic pathways. Potential applications include the study of drug resistance and metabolism or development of synthetic tools for large-scale genetic perturbation analysis.

Postdoctoral Fellow – Computational Genomics.
Seeking a creative and talented postdoctoral fellow interested in using causal reasoning to reveal cellular pathways and drug mechanism of action via integration and analysis of large-scale genomic and proteomic experiments. Involves large-scale data from ongoing collaborations on protein interaction mapping, high-content cellular and organismal phenotyping, protein expression and metabolite profiling, and discovery of genetic interactions to identify and characterize biological pathways. Qualifications are a track record of imaginative quantitative research and a solid foundation in a substantial subset of computer science, mathematics, statistics, genetics and molecular biology.

To apply for any of these positions, please submit a curriculum vitae and contact information for three references to fritz_roth@hms.harvard.edu.
http://llama.med.harvard.edu/positions.html

(posted April 23, 2010)
== Postdoctoral Position in Cell Biology (Yeast) : IGBMC, Strasbourg, France==

A postdoctoral position is open in Strasbourg (France) at the European Center, Institute
of Genetics and Molecular and Cellular Biology (IGBMC): the project will focus on the
dynamics of the cytokinetic ring in the fission yeast ''S. pombe''. The roles of the GTPase
Rho, actin polymerisation, and myosin will be studied. The work will involve genetics,
cell biology, microscopy, microfabrication and microfluidics; for more information, send
a CV and contact information of referees to Dr. Daniel Riveline (riveline@unistra.fr)

== '''PhD and Postdoctoral positions, Institute of Environmental Sciences at the Jagiellonian University, Kraków, Poland''' ==

“-Molecular mechanisms of genetic and environmental interactions for fitness in the budding yeast ''S. cerevisiae''” in the laboratory of professor Ryszard Korona

Institute of Environmental Sciences at the Jagiellonian University is opening applications for: 4-year interdisciplinary doctoral studies programme in ecology in English, with net-scholarships 2200 PLN per month, offering research in Poland and half- year placements in academic centres outside Poland and a choice of 4 out of 8 courses from different scientific disciplines conducted by eminent Polish and foreign specialists
Application deadline: 10 June 2010

20-month fellowship programme for strongly motivated scientists with a PhD degree in Biology, Ecology or related field, with net- fellowship 3200 PLN per month plus social benefits, realised in one of the research groups at the Institute of Environmental Sciences and a monthly internship at universities in Europe and the U.S.
Application deadline: 30 April 2010

Detailed information, containing the list of all research topics proposed for PhD students, profile of the applicant and application instructions is available at http://www.eko.uj.edu.pl/ecology/.

Project co-financed by the European Union under the European Social Fund

= Postdoctoral research position, Harvard University=

Postdoctoral research position is available for a scientist to
investigate host-pathogen interactions using C. elegans (J Exp Med
2009, 206:637-53; PNAS 2008,105:14585-90; PLoS Pathog. 2007, 3:e101
and e18; Eukaryot Cell 2009;8:732-7). Please send letter of
application, curriculum vitae, statement of research interests, and
have 3 current letters of professional reference emailed to
Dr. E. Mylonakis emylonakis[AT]partners.org. (posted September 2, 2009)

MGH is an AA/EEO employer.

[http://www2.massgeneral.org/id/labs/mylonakis/ http://www2.massgeneral.org/id/labs/mylonakis]

[http://chemicalbiology.mgh.harvard.edu/labs-mylonakis.htm http://chemicalbiology.mgh.harvard.edu/labs-mylonakis.htm]

= Postdoctoral Research Associate at Department of Plant Sciences, University of Cambridge=

Postdoctoral Research Associate in the group of Dr Janneke Balk, Department of Plant Sciences, University of Cambridge

Salary: £27,183-£35,469 pa Limit of tenure: grant funding is available for 3 years in the first instance. Start date: 1 January 2010

Applicants must have a PhD, and a background in fungal genetics will be highly preferred. Previous experience in molecular biology and biochemistry methods is essential. This project is funded by the Wellcome Trust and includes part-time technical assistance.

The assembly of iron-sulphur cofactors in respiratory complex I

Complex I deficiencies are the most common cause of respiratory chain dysfunction, but how this largest of the respiratory complexes is assembled, including its unique chain of eight iron-sulphur (Fe-S) clusters, is poorly understood. This project aims to investigate the assembly of complex I using the yeast Yarrowia lipolytica as a genetic model organism, and will focus on: 1) Further analysis of the molecular role of Ind1, a recently identified Fe-S scaffold protein important for complex I assembly in Yarrowia and human cell lines (Bych et al 2008; Sheftel et al, unpublished). 2) Development of Yarrowia yeast as a genetic model organism to perform forward genetics screens, complemented by a biochemical approach, to identify additional complex I assembly factors, in particular those that assist Ind1 with Fe-S cluster insertion. 3) Translation of the findings to human disease: identification of human orthologues and whether they are implicated in complex I disorders.

This project involves collaborations with Dr Judy Hirst at the MRC Cambridge (in vitro cluster assembly in complex I subunits), Professor Ulrich Brandt, Frankfurt (complex I function and genetics in Yarrowia yeast) and Professor Jan Smeitink, Nijmegen (translation of the findings to human respiratory disease).

Dr Janneke Balk started an independent research group in 2005, focussing on Fe-S protein biogenesis in (higher) eukaryotes. Her dynamic and international group is rapidly expanding and moving to new laboratory space this autumn.

The University of Cambridge is a world-class research institute, which is particulary strong in biomedical sciences.

Reference: Bych K, Kerscher S, Netz DJA, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U and Balk, J (2008). The iron-sulfur protein Ind1 is required for effective complex I assembly. EMBO J. 27, 1736-46.

For further enqueries: Janneke Balk, jb511@cam.ac.uk To apply, see http://www.plantsci.cam.ac.uk/jobs/content.html

=Postdoctoral Position at University of Texas Health Science Center at San Antonio=

A postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine morphology and virulence of ''Candida albicans'', the major fungal pathogen, in response to host environmental cues (for additional details see Carlisle, et al., PNAS 106:599-604 (2009)[http://www.pnas.org/content/106/2/599.long], Banerjee et al., MBC 19:1354-1365 (2008)[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18216277] and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis.

Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis, as well as ''S. cerevisiae'' researchers interested in transitioning to fungal pathogenesis, are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu).

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

=Postdoctoral or Staff Scientist Position at Purdue University=

Postdoctoral/Staff scientist position available in yeast functional genomics of chromosome segregation at Purdue University. Project goals are to define, on a global scale, the effect of phosphorylation by the Aurora kinase on protein interactions controlling chromosome segregation process in yeast. Project is funded for up to five years by NIH and will involve high-throughput screening and lab automation, genome-wide studies, microscopy, yeast molecular biology and bioinformatic analysis. Applicants should have a recent PhD in any field of biology that includes a strong conceptual and experimental background in Genetics, and/or Molecular and Cell Biology.

Applicants should send a CV by email to Dr. Tony Hazbun listed at the following web site:
http://www.mcmp.purdue.edu/faculty/?uid=hazbun

=Postdoctoral Position at Rutgers University=

A postdoctoral position is available at the Biotech Center at Rutgers University in the laboratory of Dr. Nilgun E. Tumer to investigate the mechanisms of uptake, transport and cytotoxicity of ricin and Shiga-like toxins. The Tumer lab works on elucidating the basic mechanisms of action of ricin and Shiga-like toxins using Saccharomyces cerevisae and C. elegans as model systems. Both toxins depurinate the sarcin/ricin loop of the large rRNA and inhibit translation. Our goal is to identify the targets of these toxins to understand the mechanism by which they kill cells and to develop therapeutic intervention strategies. The successful candidate will use genetic, cell biology and chemical genomic approaches to investigate the mechanism of uptake and transport of the toxins in yeast and C. elegans and use chemical genomics approaches to identify the cellular pathways affected by these toxins. The ideal candidate should have a Ph.D. in a related field, experience with yeast and/or C.elegans genetics and cell biology and familiarity with chemical biology approaches. The Biotech Center is located in New Brunswick, New Jersey near New York City and Philadelphia and is equipped with state-of-the-art facilities and instrumentation. Rutgers University is an equal opportunity employer that strongly encourages underrepresented groups to apply for open positions.

Interested applicants should send their CV and names and addresses of three references to Dr. Nilgun E. Tumer (tumer@aesop.rutgers.edu). Information on our research can be found at: http://biotech.rutgers.edu/faculty/tumer.html, http://aesop.rutgers.edu/~plantbiopath/faculty/tumer/TUMER.HTML, http://lifesci.rutgers.edu/~molbiosci/faculty/tumer.html
Contact: Nilgun Tumer, Foran Hall, Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901-8520. Tel: 732-932-8165 X215.

=Postdoctoral Position, Chemical Genomics=

Research Department: Molecular Ligand Target Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute
Dr. Charles Boone, Visiting Scientist
Dr. Minoru Yoshida, Team Leader

Location: RIKEN Advanced Science Institute, RIKEN Wako Institute, Hirosawa 2-1, Wako, Saitama 351-0198, Japan

Area of Research: Chemical genetics and chemical genomics

Job Description: A postdoctoral researcher position is open in the field of chemical genomics. We have constructed a unique chemical library based on natural products in the Department of Chemical Biology, RIKAN Advanced Science Institute. The successful candidate will carry out original research on global analysis of drug-target interaction using the chemical library and various yeast mutants or transformants.

Selection Process: Candidates will be selected based on research results, publications, letters of recommendation (preferably in English), etc. The CV (preferably detailed and complete) and publications must be in English.

Application Deadline: Applications are now being accepted. Position will be closed after a suitable candidate is found.

Start of Employment: Immediately

Contract Conditions: Full-time employment with the contract shall be for one year, renewable annually upon evaluation until the end of the project (March 2012). Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Moving expenses to RIKEN will be reimbursed. Social insurance will also be applicable. Days off include public holidays, New Year's holidays (Dec. 29-Jan 3), summer holidays and RIKEN Foundation Day. These and other employment provisions are in accordance with RIKEN regulations.

Information at Web: Information on our team can be found on our website (http://www.riken.go.jp/engn/r-world/research/lab/asi/chemical/index.html)

Applications: Electronic copies of your curriculum vitae/résumé, a list of publications, two or three representative publications, and two reference letters should be sent to the address below or via e-mail to "charlie.boone" (add @utoronto.ca" to complete the address):
Charles Boone
Professor, University of Toronto, Donnelly CCBR
160 College St, Rm 1306
Toronto, ON
M5S 3E1

Notes: The documents you submit will be handled with the utmost care in accordance with RIKEN's rules for the protection of personal data and will be used only for employment screening purposes. This information will not be divulged, assigned, or loaned to a third party without legitimate reason.

=Postdoctoral Position: Engineering sea lamprey antibodies=

A vacant postdoctoral position at the Center of Marine Biotechnology in Baltimore to characterize antigen binding properties of VLR, the unique variable lymphocyte receptors of sea lamprey. The successful candidate will join a study with the goal to explore biotechnology applications for these novel antibodies (Pancer & Mariuzza, Nat. Biotechnol., 2008; Rogozin et al., Nat. Immunol., 2007; Alder et al., Science 2005; Pancer et al., Nature 2004). Our research platform includes yeast displayed recombinant VLR libraries that are screened with various antigens. Biochemical and structural properties of monoclonal VLRs are then characterized.

Candidates must have a PhD with solid background in protein biochemistry and molecular biology, experience in recombinant protein expression and characterization, and relevant peer-reviewed publications.

To apply for position #300957 please submit a letter describing your research interests and experience, an updated curriculum vitae and names of three references via http://www.cytiva.com/umbi/ext/detail.asp?jobid=umbi300957

Contact: Zeev Pancer, PhD
Center of Marine Biotechnology, UMBI
Columbus Center, Suite 236
701 East Pratt St. Baltimore, MD 21202, USA
Office: 410-234-8834; Fax: 410-234-8896
Email: pancer@comb.umbi.umd.edu

=Epigenetic Postdoctoral Fellow Posting=

'''Postdoctoral positions''' are available at Massachusetts General Hospital Cancer Center. My laboratory is focused on understanding the impact that both methylation and acetylation dynamics has in both human cell culture and C. elegans. In particular, the laboratory is investigating the impact that the histone 3 lysine 9/36 tri-demethylases [JMJD2A-D; Whetstine et al., (2007) Cell 125: 467-81] have on tumorigenesis, transcriptional regulation, and genomic integrity. The laboratory will interrogate the role of these enzymes by using genomic, proteomic, cytological and genetic approaches. Similar approaches allowed an important link to be established for histone deacetylase 1 (HDAC-1) and the regulation of extra-cellular matrix biology in both human and C. elegans, which has direct implications in cancer chemotherapy [Whetstine et al., (2005) Mol. Cell 18:483-90]. The laboratory will continue to investigate the functional overlap or unique pathways that the C. elegans class I histone deacetylases regulate by using the same type of approaches. Overall, the laboratory will integrate a number of approaches and systems to determine the important biological pathways regulated by histone demethylases and histone deacetylases.

The laboratory is looking for highly motivated, tenacious scientists that are enthusiastic, team players and love science. The laboratory is looking for researchers with documented proficiency in any of the following areas (basic molecular biology, protein biochemistry, genomics, epigenetics, C. elegans, cytology, development biology, DNA damage and repair) but interested in learning new approaches or systems to answer the exciting questions before us.

Requirements:
For these positions a Ph.D. and/or M.D. is required. These positions require enthusiastic, self motivated, independent thinkers with strong interpersonal skills, and the ability to communicate with laboratory members, national and international collaborators. Please have three letters of recommendation sent to the below address and/or e-mail.

Johnathan R. Whetstine, Ph.D.
Assistant Professor of Medicine
Harvard Medical School and
Massachusetts General Hospital Cancer Center
Building 149, 13th Street , Room 7-213
Charlestown, MA 02129, USA
Office Phone: 617-643-4374
jwhetstine@hms.harvard.edu

= B.A./B.S. Yeast Biochemist at Gevo, Inc., Englewood, CO, USA=

Gevo, Inc. is a high energy, team-oriented company that is pioneering the advanced green energy industry. We are looking for a term (up to one year) Biocatalyst Development Biochemist, based in Englewood, Colorado. This role is responsible for execution of analysis of metabolites on yeast biocatalysts under the direction of a senior scientist. This person will characterize yeast biocatalysts for their intra- and extracellular metabolite production, genotypes, and phenotypes. This position is considered a term position for up to one year.

Requirements include:
Bachelor degree in Biochemistry, Chemistry, Biotechnology, Microbiology or related field and 1 – 3 years of professional work experience in a lab, working with biochemical techniques and yeast. A detailed job description can be found at [http://www.gevo.com/careers.php#BDT]

Positions in yeast labs

2008-04-30T22:32:15Z

JHMcCusker:

==Duke University Medical Center==

NIH-funded postdoctoral positions are available at Duke University Medical Center to study quantitative (complex) traits in “S. cerevisiae”; for example, see Nature 416:326-330 (2002) and PLoS Genetics 2(2):e13 (2006).

Applicants should have 0 to (at most) 2 years of post-doctoral experience and a strong background in at least one of three areas – yeast genetics, quantitative/population genetics and/or genomics/informatics – and a desire to expand into the other listed areas. Start dates are flexible.

See the [http://www.duke.edu/web/microlabs/mccusker/ lab website] for more information and publications. Applicants should email their curriculum vitae and the names/email addresses of three references to John McCusker.
Email: mccus001@mc.duke.edu

== University of Washington Genome Sciences Dept, Seattle, USA ==

Maitreya Dunham is moving her lab from Princeton to UW this summer, and is looking for postdoc applicants. The Dunham Lab studies evolution and systems biology in yeast from a genomic perspective. Lab interests include

*experimental evolution over a variety of conditions and genotypes
*integrating mutation and gene expression data
*aneuploidy and genome rearrangement effects on fitness and relation with transposons
*comparative genomics using ''S. bayanus''
*gene expression and genome evolution in hybrid yeasts
*technology development for chemostats, whole genome characterization, and other applications

For more information and publications, see the [http://www.gs.washington.edu/faculty/dunham.htm lab website]. Email inquiries to [mailto:maitreya@u.washington.edu maitreya@u.washington.edu]

== Carnegie Institution for Science, Stanford, California, USA ==

Highly qualified and motivated individuals are invited to send applications for
a Postdoc Position
in the Research Group of Wolf B. Frommer
on the topic

'''Regulatory circuits controlling sugar flux in yeast grown on ethanol'''

HT screen of the yeast knock out collection using FRET sensors for glucose, sucrose and maltose, follow-up analysis of hits and reconstruction of networks

Our lab has developed a wide range of FRET sensors for metabolites. These sensors have so far been used mainly in mammalian cells to study glutamate release from neurons, glucose transport across the ER membrane or tryptophan/kynurenine exchange.

We have now been able to functionally express the FRET sensors also in the cytoplasm of yeast and to establish a high throughput screening platform. Our goal is to identify novel regulatory pathways involved in the control of glucose flux in yeast. As a first step, the kinase k.o. collection has been screened for altered glucose flux and several hits have been identified and verified.

Next steps will be to verify the hits using a new microfluidic platform, to test the effect on other sugar fluxes using FRET sensors for sucrose, maltose and ribose and to place the kinases into signaling networks. The screen can be expanded to include the whole genome at a later stage. Focus points are regulatory effects on glucose transporters and hexokinases. Due to the advanced stage, it is expected that the work will lead to high profile publications within less than a year.

Start date asap

Send your application with CV and the names of three references to:

Wolf B. Frommer
Carnegie Institution for Science
260 Panama St, Stanford CA 94305 USA.
Website[http://carnegiedpb.stanford.edu]
E-mail: wfrommer@stanford.edu