Difference between revisions of "YDR062W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:17, 30 January 2007

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Systematic name YDR062W
Gene name LCB2
Aliases SCS1, TSC1
Feature type ORF, Verified
Coordinates Chr IV:576471..578156


Description of YDR062W: Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine[1][2]




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Community Commentary

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References

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  1. Zhao C, et al. (1994) Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. J Biol Chem 269(34):21480-8 SGD PMID 8063782
  2. Nagiec MM, et al. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A 91(17):7899-902 SGD PMID 8058731

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