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YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, NADH ubiQuinone Reductase 1

--Carletrix 07:30, 17 September 2007 (PDT)