YFL031W

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Systematic name YFL031W
Gene name HAC1
Aliases ERN4, IRE15
Feature type ORF, Verified
Coordinates Chr VI:75179..76147
Primary SGDID S000001863


Description of YFL031W: Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis[1][2][3][4][5][6][7][8][9][10]




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References

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  1. Chapman RE and Walter P (1997) Translational attenuation mediated by an mRNA intron. Curr Biol 7(11):850-9 SGD PMID 9382810
  2. Cox JS and Walter P (1996) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87(3):391-404 SGD PMID 8898193
  3. Gonzalez TN, et al. (1999) Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J 18(11):3119-32 SGD PMID 10357823
  4. Kaufman RJ (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13(10):1211-33 SGD PMID 10346810
  5. Kawahara T, et al. (1997) Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell 8(10):1845-62 SGD PMID 9348528
  6. Mori K, et al. (1996) Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1(9):803-17 SGD PMID 9077435
  7. Mori K, et al. (1998) Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae. J Biol Chem 273(16):9912-20 SGD PMID 9545334
  8. Nojima H, et al. (1994) Hac1: a novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdc10 mutant of Schizosaccharomyces pombe. Nucleic Acids Res 22(24):5279-88 SGD PMID 7816617
  9. Sidrauski C and Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90(6):1031-9 SGD PMID 9323131
  10. Welihinda AA, et al. (2000) The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo. J Biol Chem 275(5):3377-81 SGD PMID 10652329

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