YBL064C

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Systematic name YBL064C
Gene name PRX1
Aliases
Feature type ORF, Verified
Coordinates Chr II:101156..100371
Primary SGDID S000000160


Description of YBL064C: Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress[1][2][3][4][5]




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Interactions

Regulatory

YBL064C is regulated by TOR1.Regulatory interaction with TOR1
PRX1 mRNA expression is down regulated by TOR1p in the presence of glucose. [6] [7]


YBL064C is regulated by Msn2.Regulatory interaction with Msn2
YBL064c is up regulated by Msn2p/Msn4p during glucose exhaustion (cells grown in respiratory carbon sources, such as glycerol / ethanol). Exogenously added cAMP represses the induction of YBL064c mRNA expression even in respiratory conditions. [8] [9]


YBL064C is regulated by Hap1.Regulatory interaction with Hap1
YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. [8] [9]





References

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  1. Grant CM (2001) Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 39(3):533-41 SGD PMID 11169096
  2. Greetham D and Grant CM (2009) Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo. Mol Cell Biol 29(11):3229-40 SGD PMID 19332553
  3. Pedrajas JR, et al. (2000) Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J Biol Chem 275(21):16296-301 SGD PMID 10821871
  4. Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 SGD PMID 17761666
  5. Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
  6. Monteiro G and Netto LE (2004) Glucose repression of PRX1 expression is mediated by Tor1p and Ras2p through inhibition of Msn2/4p in Saccharomyces cerevisiae. FEMS Microbiol Lett 241(2):221-8 SGD PMID 15598536
  7. submitted by Gisele Monteiro on 2005-01-03
  8. 8.0 8.1 Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 SGD PMID 11827753
  9. 9.0 9.1 submitted by Gisele Monteiro on 2003-03-31

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